Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma

Goyal, Amrita; Solus, Jason F.; Chan, May P.; Doyle, Leona A.; Schaffer, András; Horn, Thomas; Duncan, Lyn M.; Nazarian, Rosalynn M.

doi:10.1111/cup.12700

Cited by 10 publications

(10 citation statements)

References 31 publications

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“…18 While diffuse positive staining is seen in BCC cases, a patchy and peripheral rim staining is found in the basaloid islands of lymphadenoma. 18 In contrast to BCC, syringoma is quite common in children. Clear cell syringoma is another potential differential diagnosis for lymphadenoma.…”

Section: Discussionmentioning

confidence: 98%

“…While scattered Merkel cells [highlighted with cytokeratin (CK)20] are present in cutaneous lymphadenoma, they are absent in BCC . Recently, CK17 has been proven of use in distinguishing BCC from lymphadenoma . While diffuse positive staining is seen in BCC cases, a patchy and peripheral rim staining is found in the basaloid islands of lymphadenoma …”

Section: Discussionmentioning

confidence: 99%

“…Recently, CK17 has been proven of use in distinguishing BCC from lymphadenoma . While diffuse positive staining is seen in BCC cases, a patchy and peripheral rim staining is found in the basaloid islands of lymphadenoma …”

Section: Discussionmentioning

confidence: 99%

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Congenital cutaneous lymphadenoma

et al. 2017

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Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only 1 previous case of a congenital lymphadenoma. An 8-year-old Asian girl presented with a congenital lesion on her forehead comprising 4 pink papules, the largest 5 mm in diameter. Microscopy revealed a well-circumscribed tumor within the dermis and subcutis comprising well-demarcated epithelial lobules of basaloid and clear cells with subtle peripheral palisading, growing in a collagenous stroma but lacking retraction artefact. A relatively dense accompanying predominantly lymphocytic inflammatory cell infiltrate including both T-cells (CD3+) and B-cells (CD20+) permeated the nodules and spilled into the stroma. CD68+ histiocytes and CD1a+ Langerhans cells were moderately numerous. This is the second case of congenital lymphadenoma which-in spite of its rarity in childhood-widens the diagnostic possibilities of cutaneous lymphoepithelial tumors in children.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Congenital cutaneous lymphadenoma

et al. 2017

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“…The evidence of Merkel cells in adnexal tumors can be very informative. It has been used to distinguish, for instance, basal cell carcinoma (BCC) from morphological mimics such as trichoepithelioma, trichoblastoma, and cutaneous lymphadenoma . CK 20‐positive Merkel cells can also help to distinguish basaloid epidermal proliferations overlying dermatofibromas (with Merkel cells) from BCC (without them) .…”

Section: Discussionmentioning

confidence: 99%

Merkel cells in extraocular sebaceous carcinoma

Fernández-Flores

2018

J Cutan Pathol

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Introduction Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid‐like or labyrinthine pattern can contain intratumoral Merkel cells. Our purpose in this study is to examine for the presence of Merkel cells in extraocular sebaceous carcinomas. Methods Nineteen cases of extraocular sebaceous carcinoma were retrospectively studied with cytokeratin 20. Results One out of 19 cases (5.3%) contained Merkel cells in the basal layers of the tumoral nests of a sebaceous carcinoma from the cheek of a 76‐year‐old woman. Conclusions Merkel cells are rarely evident in extraocular sebaceous carcinoma, and therefore, their evidence does not exclude this diagnosis.

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“…They are usually negative with Cam5.2, AE1: AE3, EMA and cytokeratin (CK)7 [50]. CK17 is diffusely expressed in BCC [51].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Pattern of Basal Cell Carcinoma among Sudanese Patients

Sulieman¹,

Husain²

2017

OJPathology

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Background: Basal cell carcinoma (BCC) is a frequently diagnosed skin cancer with variable histopathological types. BCC was not widely studied in Sudan as it is in the Caucasian population. Objectives: To appraise the clinical and histopathological aspects of BCC of the skin in Sudan. Materials and methods: A retrospective descriptive analysis of 84 histologically diagnosed BCC specimens seen at three hospitals in four-year duration were reviewed and classified into histological variants according to the WHO classification 2006. Data were analyzed using Statistical Package for the Social Sciences, version 23.0. Results: The mean age (±SD) of the study participants was 56 (±1.75) years, ranging from 20 to 92 years and 63.1% were females (Female to male ratio 1.7:1). The most common incidence was among the age group 51 -60 years. The face was the primary tumor site in 89.3% with a predilection for the nasal area (31% of those in the face), followed by the trunk (6%). Out of the total, 54.8% were histologically categorized as nodular/solid, while infiltrative accounts for 11.9% followed by the superficial type (8.3%). Surgical margins were involved in 34.5% of cases and peri-neural invasion was seen in 3.6% of cases, mostly were of the infiltrative variant. Conclusion: BCC in Sudan is commonly present in the head as solid nodular histopathological variant which is correlated with worldwide distribution but has slightly younger age and female predominance; thus further studies are needed to assess risk factors in Sudanese patients and improve approaches for earlier diagnosis and better management.

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Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma

Abstract: In cases with a differential diagnosis of CL and BCC, CK20 staining of intratumoral MCs has a high positive predictive value for CL but is of low sensitivity. The pattern of CK17 expression is a highly sensitive marker for distinguishing CL from BCC in small samples.

Cited by 10 publications

References 31 publications

Congenital cutaneous lymphadenoma

Congenital cutaneous lymphadenoma

Merkel cells in extraocular sebaceous carcinoma

Clinicopathological Pattern of Basal Cell Carcinoma among Sudanese Patients

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