Life‐span carcinogenicity studies on Sprague–Dawley rats exposed to γ‐radiation: Design of the project and report on the tumor occurrence after post‐natal radiation exposure (6 weeks of age) delivered in a single acute exposure

Soffritti, Morando; Tibaldi, Eva; Bua, Luciano; Padovani, Michela; Falcioni, Laura; Lauriola, Michelina; Manservigi, Marco; Manservisi, Fabiana; Belpoggi, Fiorella

doi:10.1002/ajim.22391

Cited by 5 publications

(2 citation statements)

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“…The dose of the positive controls (0.1 Gy) was selected so as to have a comparison with the results of a previous larger experiment on the carcinogenicity of γ radiation, in which the lowest dose tested was 0.1 Gy. 31 The results of the study are reported in Tables 5-8. Table 5 shows that exposure to 1000 μT S-50 Hz MF plus 0.1 Gy induces a statistically significant dose-related increase (P ≤ 0.01) in males bearing malignant tumours compared to negative controls, in particular at the highest…”

Section: Groupmentioning

confidence: 99%

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The carcinogenic potential of non‐ionizing radiations: The cases of S‐50 Hz MF and 1.8 GHz GSM radiofrequency radiation

Soffritti

Giuliani²

2019

Basic Clin Pharma Tox

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Epidemiological studies have suggested that human exposure to extremely low‐frequency electromagnetic fields from the electric power and to mobile phone radiofrequency electromagnetic fields induce an increased risk of developing malignant tumours. However, no adequate laboratory data, in particular long‐term carcinogenicity bioassays to support the epidemiological evidence, have yet been available. This motivated the Ramazzini Institute to embark on a first project of four large life‐span carcinogenic bioassays conducted on over 7000 Sprague Dawley rats exposed from prenatal life until natural death to S‐50 Hz MF alone or combined with gamma radiation or formaldehyde or aflatoxin B1. Results now available from these studies, which started concurrently, have shown that exposure to Sinusoidal‐50 Hz Magnetic Field (S‐50 Hz MF) combined with acute exposure to gamma radiation or to chronic administration of formaldehyde in drinking water induces a significantly increased incidence of malignant tumours in males and females. A second project of two large life‐span carcinogenic bioassays was conducted on over 3000 Sprague Dawley rats exposed from prenatal life until natural death to 1.8 GHz GSM of mobile phone radio base station, alone or combined with acute exposure to gamma radiation. Early results from the experiment on 1.8 GHz GSM alone show a statistically significant increase in the incidence of heart malignant schwannoma among males exposed at the highest dose.

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Section: Groupmentioning

confidence: 99%

“…All the four experimental groups encompassed 1658 rats. The dose of the positive controls (0.1 Gy) was selected so as to have a comparison with the results of a previous larger experiment on the carcinogenicity of γ radiation, in which the lowest dose tested was 0.1 Gy . The results of the study are reported in Tables 5‐8.…”

Section: Introductionmentioning

confidence: 99%

The carcinogenic potential of non‐ionizing radiations: The cases of S‐50 Hz MF and 1.8 GHz GSM radiofrequency radiation

Soffritti

Giuliani²

2019

Basic Clin Pharma Tox

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Results of lifespan exposure to continuous and intermittent extremely low frequency electromagnetic fields (ELFEMF) administered alone to Sprague Dawley rats

Bua

Tibaldi

Falcioni

et al. 2018

Environmental Research

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Genetic instability and aging under the scrutiny of comparative biology: a meta-analysis of spontaneous micronuclei frequency

Croco

Marchionni

Lorenzini

2016

Mechanisms of Ageing and Development

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Life‐span carcinogenicity studies on Sprague–Dawley rats exposed to γ‐radiation: Design of the project and report on the tumor occurrence after post‐natal radiation exposure (6 weeks of age) delivered in a single acute exposure

Abstract: Our data show that exposure to γ-radiation induces carcinogenic effects at all tested doses.

Cited by 5 publications

References 35 publications

The carcinogenic potential of non‐ionizing radiations: The cases of S‐50 Hz MF and 1.8 GHz GSM radiofrequency radiation

The carcinogenic potential of non‐ionizing radiations: The cases of S‐50 Hz MF and 1.8 GHz GSM radiofrequency radiation

Results of lifespan exposure to continuous and intermittent extremely low frequency electromagnetic fields (ELFEMF) administered alone to Sprague Dawley rats

Genetic instability and aging under the scrutiny of comparative biology: a meta-analysis of spontaneous micronuclei frequency

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