Phosphorus–nitrogen compounds. Part 29. Syntheses, crystal structures, spectroscopic and stereogenic properties, electrochemical investigations, antituberculosis, antimicrobial and cytotoxic activities and DNA interactions of ansa-spiro-ansa cyclotetraphosphazenes

The Syntheses and Structural Characterizations, Antimicrobial Activity and in Vitro Dna Binding of 4-Fluorobenzylspiro(n/O)cyclotriphosphazenes and Their Phosphazenium Salts

“…The MBC and MFC are the lowest concentration of the compound that kills 99,9% of the initial microorganism concentration. Determination of the pUC18 plasmid DNA interaction with the compounds: The interactions of the cyclotriphosphazenes and the PILs with the pUC18 plasmid DNA were evaluated using agarose gel electrophoresis [29]. The compounds were incubated with pUC18 plasmid DNA in an incubator at 37 ⁰C for 24 h in the dark.…”

Chiral configurations in cyclophosphazene chemistry

“…two racemic diastereoisomers, if the 1,3-centers of chirality are different, and one meso (1,3-cis arrangement) and one racemic diastereoisomer (1,3-trans arrangement), if the 1,3-centers of chirality are the same. Crystallographic examples 96 [116], 97a-c [115] and 97d,e [117] are M a n u s c r i p t 32 shown below for 1,5-trans (racemic) form. There is only one crystal compound, 98, including also pseudoasymmetric center (discussed in Section 4.2), for 1,5-cis (meso) form.…”

“…Compound 123 [156] which has a pseudoasymmetric center is a meso form. Although it is of interest to find that a number of metallo-cyclotriphosphazenes have centers of chirality and that they exist in racemic or meso forms (107)(108)(109)(110)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123), it is perhaps more important for the synthetic chemist to understand what structural types lead to metallocyclophosphazenes with centers of chirality, especially because an achiral molecule may become chiral after complexation. The compounds (107)(108)(109)(110)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123) should be sub-divided into catagories that depend primarily on the number of binding sites of the metal to the cyclophosphazene derivative and then by the configurational arrangement of the substituents involved in the binding and whether skeletal nitrogens are also involved in complexation, because this leads to great diversity of binding modes.…”

Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene‐Bridged Cyclophosphazenes

“…Similar to intercalators, the groove binders are clinically important as anticancer and antibacterial agents . Cyclophosphazene derivatives have also been studied due to their potential use as anticancer and antimicrobial agents . Hexachlorocyclotriphosphazene (N 3 P 3 Cl 6 , trimer) and octachlorocyclotetraphosphazene (N 4 P 4 Cl 8 , tetramer) are the best known members of cylophophazenes.…”