Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene‐Bridged Cyclophosphazenes

Yıldırım, Tuba; Şenkuytu, Elif; Ergene, Emel; Bılgın, Kemal; Uludag, Yildiz; Çiftçi, Gönül Yenilmez

doi:10.1002/slct.201801766

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…A few fluorenylidenebridged cyclophosphazenes 8a-c (Fig. 8) have been reported to possess antibacterial activity against some Gram-positive and Gram-negative bacteria [55]. The derivatives 8b and 8c exhibit good antibacterial activities against S. aureus ATCC25923, E. coli ATCC35218, and P. aeruginosa ATCC27853 with inhibition zones ranging from 25 to 37 mm.…”

Section: Fig (3)mentioning

confidence: 99%

Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

Wang

Xie

et al. 2021

COC

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: As a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used for synthesis of varieties of derivatives, including metal-binding complexes and several unique organometallic compounds, which exhibit potential catalytic, flame retardant and biological activities. Some metal-binding HCCP derivatives have shown antibacterial activities as free ligands and metal complexes. These derivatives can also serve as building blocks for the formation of antibacterial metal- containing polymers. This mini-review is focused on the design and development of HCCP derivatives as potential antibacterial agents with representative examples from recent years, as well as antibacterial mechanisms are also pointed out.

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Section: Fig (3)mentioning

confidence: 99%

Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

Wang

Xie

et al. 2021

COC

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“…Also, they can be used as ligand in coordination chemistry and organometallic chemistry (10)(11)(12)(13)(14). Six-membered trimer (P3N3) is more preferred and studied than eight-membered tetramer (P4N4) because it is planar, stable, rigid, and its product range is less than tetramer (17)(18)(19)(20). Thus, an easily functionalized platform is created for the preparation of compounds suitable for different and new application areas such as biologically active materials, liquid crystallinity, anticancer agents, fluorescent chemosensors and organic light emitting diodes (21)(22)(23)(24)(25)(26).…”

Section: Cyclophosphazenesmentioning

confidence: 99%

2-Naphthylthio Cyclotriphosphazene Derivatives: Synthesis, Characterization, Crystallographic and Fluorescence Properties

Balcı

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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In this study, new cyclotriphosphazene derivatives bearing 2-naphthylthio group were reported. The reactions of hexachlorocyclotriphosphazene (1) with 2-naphthalenethiol (2) were carried out with NaH base in tetrahydrofuran solution under inert (Ar) atmosphere in (1:2), (1:4) and (1:6) molar ratios. As a result of the reactions, bis geminal (3), tetrakis (4) and hexakis (5) 2-naphthylthio substituted cyclotriphosphazene derivatives formed and isolated. These new compounds were characterized with elemental analysis, mass (MALDI-TOF) analysis, 31 P{H} and 1 H NMR spectroscopies. The molecular structure of compound 3 was illuminated by single-crystal X-Ray diffraction technique. Furthermore, the fluorescence properties of the newly designed and synthesis compounds (3-5) were examined.

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“…Such multi‐site ligands show facile coordination of with main group, transition and rare earth metals to afford wide range of metal complexes, metallamacrocycles, clusters and polymeric networks. The variation of substituents on phosphorous centres tends to tune the electronic properties of the entire molecule, which leads to the versatile coordination properties towards subsequent applications [11–17] . Indeed, CTP based metal clusters and coordination polymers are used in numerous applications such as catalyst, [18–23] antibacterial agents, [24,25] gas adsorption, [26–28] gas separation [29,30] and sensors [31–33] etc.…”

Section: Introductionmentioning

confidence: 99%

Multisite Coordination Ligands on Cyclotriphosphazene Core for the Assembly of Metal Clusters and Porous Coordination Polymers

et al. 2021

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In this review, we account the recent advancements on cyclotriphosphazene (N3P3Cl6) based multi‐site coordination ligands for the synthesis of multi‐metallic architectures. In case of N3P3Cl6, Phosphorous centres with two chlorides use to be bonded with nitrogen [−P(Cl2)=N−]3 at alternative positions in six membered ring to provide a robust planar structure to anchor the ligand arms with wide flexibility. Cyclic P−N robust motif is renowned as the potential support for the design of multi‐site ligands originating from phosphorus centres by viable substitution of variable number of ligand units (1 to 6) consist of one or more coordination site(s) via geminal and/or non‐geminal modes. Despite these phosphorus centres are promising to support in ligand structure, occasionally involve in coordination with transition metals as well. Three of alternative nitrogen atoms in this heterocyclic core are supposed to function as Lewis base centres while the electron releasing substituents occurred to tether on phosphorus centres, also when the resultant ring size favours adequate interaction towards the transition metal ions with respect to skeletal flexibility. The ligand modes vary with respect to numbers and orientation of coordination sites, which is imperative to enrich the ligation ability. Moreover, several examples of cyclotriphosphazene core ligands consist of the spacer oxygen atom while tethering with exocyclic ligand units to incorporate more flexibility. In accordance with coordination sites on ligand framework and choice of metal, the skeletal ring nitrogen atom(s) of the cyclotriphosphazene can be involved in coordination with metal ions. Indeed, the coordination of ligands is reported to coordinate with main group, transition and lanthanide metal ions to form variety of metal clusters and porous coordination polymers. Subsequently, the geometry of homo or heterometallic complexes with respect to versatile coordination modes of metallic complexes tends to afford inherent chemical properties for specific application. In terms of exocyclic ligands, the heterocyclic units such as pyridyloxy‐, pyrazolyl‐, pyridylalkylamino‐, bipyridyl‐, 1,10‐phenanthroline, porphyrinato, hydrazide, hydrazone, Schiff's base and spirocyclic amine units attached to cyclotriphosphazene were exploited to form series of metal complexes. Similarly, the variety of metal clusters, polymeric network (1D to 3D) and porous coordination polymers have been reported on basis of cyclic core molecule substituted with ligand units, pyridyloxy‐, multi‐carboxylic, aromatic amines substituted pyridyloxy‐ and imidazole moiety involved to form variety of products.

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Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene‐Bridged Cyclophosphazenes

Cited by 9 publications

References 15 publications

Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

2-Naphthylthio Cyclotriphosphazene Derivatives: Synthesis, Characterization, Crystallographic and Fluorescence Properties

Multisite Coordination Ligands on Cyclotriphosphazene Core for the Assembly of Metal Clusters and Porous Coordination Polymers

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