Antioxidant status and serum levels of selectins in pre-eclampsia

Nasrollahi, Sh; Panah, S. M. Hoseini; Tavilani, Heidar; Tavasoli, Samira; Naderan, Mohammad; Shoar, Saeed

doi:10.3109/01443615.2014.935710

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…The stronger relationship of this correlation in eclampsia that indicates further imbalance of protein oxidants and antioxidants in this group compared to the others. Though earlier studies have shown an impaired antioxidant activity in preeclampsia [32], this finding has not been uniformly reproducible [33]. Our study is the first of its kind to measure antioxidant parameters AOA and total thiols in various types of hypertensive disorders.…”

Section: Discussionmentioning

confidence: 59%

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

et al. 2016

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Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.

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Section: Discussionmentioning

confidence: 59%

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

et al. 2016

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“…Previous studies have reported elevated maternal plasma sEselectin concentrations in women with pre-eclampsia, both at the time of delivery (22)(23)(24)(25)(26) and also prior to clinical diagnosis (22). However, the available data concerning both sP-and sL-selectins (22,23,26,27) are conflicting.…”

Section: Introductionmentioning

confidence: 99%

Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

et al. 2020

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Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that circulating maternal and fetal concentrations and placental expression of selectins would be increased in women with pre-eclampsia and would be associated with the angiotensin receptors (AT1R and AT2R). Maternal and fetal blood and placental tissue was collected at delivery from White European normotensive controls (n = 17) and women with pre-eclampsia (n = 17). Soluble (s) E-, P-and L-selectin protein concentrations were measured by ELISA and placental protein expression was examined by immunohistochemistry. Maternal sE-selectin concentrations were increased in pre-eclampsia (P < 0.001); conversely fetal sE-and sP-selectin levels were lower in pre-eclampsia (P < 0.05 for both). Staining was mainly localized to the syncytiotrophoblast for all selectins. E-selectin expression was increased, while P-selectin was decreased in placental from pre-eclampsia (P < 0.05 for both); no differences were observed for L-selectin expression. Both E-and L-selectin were positively correlated (P < 0.008; P < 0.02) with AT2R placental expression, whilst P-selectin was negatively associated with AT1R (P < 0.005), all only in the pre-eclampsia group. This novel study reports maternal, fetal and placental expression of selectins in pre-eclampsia. The increased E-selectins reflect the endothelial dysfunction, characteristic of pre-eclampsia. In contrast, the reduced P-selectins and the positive association of placental AT2Rs with both E-and L-selectin in pre-eclampsia could be a protective mechanism to limit the endothelial dysfunction.

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“…The observed decrease in CD62L+ neutrophils in severe PE could be caused both by a true decrease in the level of such cells and by rapid recruitment of CD62L-positive cells from blood flow. The latter assumption seems more likely, as according to some researchers, pregnant women with PE have high serum levels the soluble form of L-selectin [16,17]. The increase in the serum level of L-selectin molecules in women with PE can be due to the elution of CD62L molecules from the cell membrane after interaction with the corresponding endothelial ligand [18], caused by growing levels of inflammatory mediators [19] or by exposure to angiotensin II cells [20].…”

Section: Resultsmentioning

confidence: 94%

Clinical value of changes of the transmigration activity of leukocytes in the diagnosis of severe preeclampsia

Panova¹,

Kudryashova²,

Rokotyanskaya³

et al. 2018

Akusherstvo i ginekologiia

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Aim. To identify additional criteria for the diagnosis of severe preeclampsia (PE) in pregnant women based on an investigation of the expression of the early adhesion molecules, chemokine receptors, and markers of endothelial dysfunction in venous blood neutrophils and monocytes. Material and methods. One hundred and fifty patients with PE (74 with moderate PE, 76 with severe PE) and 70 women with a physiological course of pregnancy were tested for venous blood neutrophils and monocytes expressing adhesion molecules CD62L, CD11b, chemokine receptors CCR2 and CX3CR1, and the number of circulating endothelial cells (CECs). Results. When compared with women having uneventful pregnancy and patients with moderate PE, patients with severe PE had significantly lower levels of CD62L+neutrophils, but higher levels of CX3CR1+monocytes and neutrophils, and a greater number of CECs. The diagnostic thresholds for these parameters are informative in the diagnosis of PE severity. Conclusion. Measuring the relative levels of CD62L+, CX3CR1+ neutrophils and the number of CECs in the blood can be used for stratifying severity of PE with greater accuracy.

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Antioxidant status and serum levels of selectins in pre-eclampsia

Cited by 13 publications

References 19 publications

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

Clinical value of changes of the transmigration activity of leukocytes in the diagnosis of severe preeclampsia

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