Ultra high performance liquid chromatography–time-of-flight high resolution mass spectrometry in the analysis of hexabromocyclododecane diastereomers: Method development and comparative evaluation versus ultra high performance liquid chromatography coupled to Orbitrap high resolution mass spectrometry and triple quadrupole tandem mass spectrometry

Advanced Mass Spectrometry

“…The Q-Orbitrap is the last addition to the family of hybrid instrument. However, it is increasingly applied, particularly, in the field of profiling and fingerprinting metabolites [18,70,161,166,167].…”

“…Effect of thermal processing [66] LC-TOF Analysis of pesticides in fruits and vegetables [67] GC-TOF Quantitative analysis of acetaldehyde in foods consumed [68] LC-TOF Screening natural antioxidants in peanut shell [69] UHPLC-TOF Hexabromocyclododecane diastereomers [70] Type Application References UHPLC-TOF 19 antibiotics in dairy products [71] MALDI-TOF Microscale strategy to detect spermine and spermidine in food [72] LC-TOF Determination of phthalates in edible salts from food markets in Korea [73] LC-QqTOF Simultaneous determination five major antioxidant compounds [74] MALDI-TOF Monitoring of she-donkey's milk contamination or adulteration [75] MALDI-TOF Quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators [76] LC-QqTOF Quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators [45] UHPLC-TOF Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant [46] LC-TOF Simultaneous investigation of sesquiterpenes, pyrrolizidine alkaloids, and N-oxides in butterbur (Petasites hybridus) [77] UHPLC-QqTOF Determination of 141 pesticides in tea [78] UHPLC-QqTOF Determination of tadalafil and N-desmethylsibutramine in health and dietary supplements [79] LC-QqTOF Seven fluorescent whitening agents in food contact paper package materials [80] Lipidomics GC × GC-TOF Unsaponifiable fraction of lipids belonging to various types of milk [22] UHPLC-QqTOF Rapid and highly accurate detection of steryl glycoside [81] MALDI-TOF Rapid lipid profiling of bacteria [82] MALDI-TOF Detection of glycated phospholipids in heattreated food samples [83] …”

Advances in enantioselective analysis of chiral brominated flame retardants. Current status, limitations and future perspectives

“…Trying to solve the problems relating to the low mass cut-off of the ionic trap (IT) and the variable amounts of other adduct peaks in the samples, an LC-ion trap (IT)-MS-MS method was applied successfully by (Gomara et al, 2007) for food samples, while developed an enantiomeric method for HBCDs in sediment samples using a LC-quadrupole linear ion trap (QqLIT)-MS-MS instrument. More recently, (Zacs et al, 2014) developed an ultrahigh performance liquid chromatography (UHPLC) -time-of-flight high resolution mass spectrometry (TOF-HRMS) method for the determination of hexabromocyclododecane (HBCD) diastereomers in fish samples and the method was compared against UHPLC-Orbitrap-HRMS and UHPLC-triplequadrupole (QqQ) tandem MS (MS/MS) techniques. (Zacs et al, 2014) found that UHPLC-TOF-HRMS operated in scan mode over the m/z range of 600-700 was demonstrated to be a good alternative to conventional LC-MS/MS systems for diastereomer analysis of HBCDs and this method could be also applied for enantiomers of HBCDs.…”

“…More recently, (Zacs et al, 2014) developed an ultrahigh performance liquid chromatography (UHPLC) -time-of-flight high resolution mass spectrometry (TOF-HRMS) method for the determination of hexabromocyclododecane (HBCD) diastereomers in fish samples and the method was compared against UHPLC-Orbitrap-HRMS and UHPLC-triplequadrupole (QqQ) tandem MS (MS/MS) techniques. (Zacs et al, 2014) found that UHPLC-TOF-HRMS operated in scan mode over the m/z range of 600-700 was demonstrated to be a good alternative to conventional LC-MS/MS systems for diastereomer analysis of HBCDs and this method could be also applied for enantiomers of HBCDs. Very recently, (Zacs and Bartkevics, 2015) identified and quantified 27 BFRs, including NBFRs ones, by developing an analytical method supported by high performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) with atmospheric pressure photoionization (APPI) interface operated in negative mode.…”

Quantitative and Qualitative LC-High-Resolution MS: The Technological and Biological Reasons for a Shift of Paradigm

“…Today, there are many peer-review articles that compare side-by-side the quantitative performance of QQQ-MS and HRMS instruments [19][20][21][22][23][24][25][26]. These comparisons investigate the sensibility, selectivity, ease of use, calibration linearity, reliability, and robustness in real-life LC-MS analyses.…”