Subjective cognitive concerns, episodic memory, and the <i>APOE</i> ε4 allele

Samieri, Cécilia; Proust‐Lima, Cécile; Glymour, M. Maria; Okereke, Olivia I.; Amariglio, Rebecca E.; Sperling, Reisa A.; Rentz, Dorene M.; Grodstein, Francine

doi:10.1016/j.jalz.2014.06.012

Cited by 62 publications

(57 citation statements)

References 41 publications

(41 reference statements)

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“…As shown in Table 1, the SCD- and SCD+ groups did not differ significantly from each other on any demographic variable, APOE ε4 allele status, or family history of dementia (all p > 0.10). The proportion of APOE ε4 allele carriers in the sample was 27%, which is similar to prevalence estimates that have been reported in other healthy adult samples [34]. As expected, no evidence of cognitive impairment was present in the sample at baseline; the average MMSE [21] score was 29.16 ± 0.94.…”

Section: Resultssupporting

confidence: 84%

“…Further, the SCD groups in our sample did not significantly differ based on family history of dementia or APOE ε4 status, which are two well-established risk factors for Alzheimer disease [27]. The proportion of APOE ε4 allele carriers in our sample was similar to the prevalence estimates found in other cognitively normal adult samples [34]. …”

Section: Discussionsupporting

confidence: 78%

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Objective features of subjective cognitive decline in a United States national database

Kielb

Rogalskı

Weıntraub

et al. 2017

Alzheimer's & Dementia

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INTRODUCTION Functional and cognitive features of subjective cognitive decline (SCD) were identified in a longitudinal database from the National Alzheimer Coordinating Center. METHODS Cognitively normal older adults with (SCD+) and without (SCD-) self-reported memory complaints (N=3915) were compared on 1) baseline Functional Assessment Questionnaire (FAQ) ratings, 2) baseline scores and longitudinal rate of change estimates from nine neuropsychological tests, and 3) final clinical diagnoses. RESULTS SCD+ had higher baseline ratings of functional impairment, reduced episodic memory practice effects and poorer performance on neuropsychological tests of psychomotor speed and language, and higher frequencies of mild cognitive impairment and dementia diagnoses at the end of follow-up compared to the SCD- group. DISCUSSION Subtle clinical features of SCD identified in this large cohort are difficult to detect at the individual level. More sensitive tests are needed to identify those with SCD who are vulnerable to cognitive decline and dementia.

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Section: Resultssupporting

confidence: 84%

Section: Discussionsupporting

confidence: 78%

Objective features of subjective cognitive decline in a United States national database

Kielb

Rogalskı

Weıntraub

et al. 2017

Alzheimer's & Dementia

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“…Given that our sample is enriched with AD FH and APOE4 positive adults; and the observed association between these familial/genetic factors and increased SCC (Dik et al, 2001; Kryscio et al, 2014; La Rue et al, 1996; Risacher et al, 2015; Samieri et al, 2014; Small et al, 2001; Tsai, Green, Benke, Silliman, & Farrer, 2006), we investigated the association between SCC and FH and APOE4 status. Our analyses revealed that neither FH nor APOE4 status was associated with Visit 1 or longitudinal self- and informant-SCC.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

Nicholas

Dowling

Racine

et al. 2017

J Int Neuropsychol Soc

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Objectives The purpose of this study was to investigate the longitudinal trajectory of self- and informant-subjective cognitive complaints (SCC), and to determine if SCC predict longitudinal changes in objective measures (OM) of cognitive function. Methods The study included healthy and cognitively normal late middle-aged adults enriched with a family history of AD who were evaluated at up to three visits over a 4-year period. At each visit (Visit 1–3), self- and informant-SCC and OM were evaluated. Linear mixed models were used to determine if the longitudinal rate of change of self- and informant-SCC were associated with demographic variables, depressive symptoms, family history (FH), and apolipoprotein epsilon 4 (APOE4) status. The same modeling approach was used to examine the effect of Visit 1 SCC on longitudinal cognitive change after controlling for the same variables. Results At Visit 1, more self-SCC were associated with fewer years of education and more depressive symptoms. SCC were also associated with poorer performance on cognitive measures, such that more self-SCC at Visit 1 were associated with poorer performance on memory and executive functioning measures at Visit 1, while more informant-SCC were associated with faster rate of longitudinal decline on a measure of episodic learning and memory. FH and APOE4 status were not associated with SCC. Discussion Self- and informant-SCC showed an association with OM, albeit over different time frames in our late middle-aged sample. Additional longitudinal follow-up will likely assist in further clarifying these relationships as our sample ages and more pronounced cognitive changes eventually emerge.

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“…Of 68,590 nurses who returned the 2012 questionnaire, we excluded 4 participants aged .55 y in 1976, 49 participants with missing information on height, and 3130 participants who were diagnosed with any of 11 chronic diseases (e.g., cancer and myocardial infarction, as addressed below) before baseline. We also excluded 480 participants who skipped .5 items on the physical function scale and 12,792 participants who skipped any item on the subjective memory or 15-item Geriatric Depression Scale (GDS-15) score, as we previously documented (21,22), which left 52,135 participants available for the present analyses (Supplemental Figure 1). The participants aged 33.5-60.6 y in 1980 and 65.5-93.3 y in 2012.…”

Section: Study Populationmentioning

confidence: 99%

“…Subjective memory complaints have been associated with performance on objective cognitive tests (21,22). No more than 1 memory complaint was considered as the absence of impairment of memory.…”

Section: Assessment Of Memorymentioning

confidence: 99%

Adult height, dietary patterns, and healthy aging

Ma¹,

Hagan²,

Heianza

et al. 2017

The American Journal of Clinical Nutrition

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Background: Adult height has shown directionally diverse associations with several age-related disorders, including cardiovascular disease, cancer, decline in cognitive function, and mortality. Objective: We investigated the associations of adult height with healthy aging measured by a full spectrum of health outcomes, including incidence of chronic diseases, memory, physical functioning, and mental health, among populations who have survived to older age, and whether lifestyle factors modified such relations. Design: We included 52,135 women (mean age: 44.2 y) from the Nurses' Health Study without chronic diseases in 1980 and whose health status was available in 2012. Healthy aging was defined as being free of 11 major chronic diseases and having no reported impairment of subjective memory, physical impairment, or mental health limitations. Results: Of all eligible study participants, 6877 (13.2%) were classified as healthy agers. After adjustment for demographic and lifestyle factors, we observed an 8% (95% CI: 6%, 11%) decrease in the odds of healthy aging per SD (0.062 m) increase in height. Compared with the lowest category of height (#1.57 m), the OR of achieving healthy aging in the highest category ($1.70 m) was 0.80 (95% CI: 0.73, 0.87; P-trend , 0.001). In addition, we found a significant interaction of height with a prudent dietary pattern in relation to healthy aging (P-interaction = 0.005), and among the individual dietary factors characterizing the prudent dietary pattern, fruit and vegetable intake showed the strongest effect modification (P-interaction = 0.01). The association of greater height with reduced odds of healthy aging appeared to be more evident among women with higher adherence to the prudent dietary pattern rich in vegetable and fruit intake. Conclusions: Greater height was associated with a modest decrease in the likelihood of healthy aging. A prudent diet rich in fruit and vegetables might modify the relation.Am J Clin Nutr 2017;106:589-96.

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Subjective cognitive concerns, episodic memory, and the APOE ε4 allele

Cited by 62 publications

References 41 publications

Objective features of subjective cognitive decline in a United States national database

Objective features of subjective cognitive decline in a United States national database

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

Adult height, dietary patterns, and healthy aging

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