Significant association of combination of OCT4, NANOG, and SOX2 gene polymorphisms in susceptibility and response to treatment in North Indian breast cancer patients

Tulsyan, Sonam; Agarwal, Gaurav; Lal, Punita; Mittal, Balraj

doi:10.1007/s00280-014-2588-4

Cited by 12 publications

(12 citation statements)

References 62 publications

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“…In India, the mean age of BC diagnosis was 53 years (Tulsyan et al, 2014), and the median age was 45 years (Krishnatreya et al, 2014). This was similar to data from China, which indicated that the estimated risk of recurrent breast cancer increased with age (mean=46 years) .…”

Section: Non-modifiable Risk Factors For Breast Cancer In Asia Agesupporting

confidence: 78%

“…BRCA1, ERCC1, TP53) (Chen et al, 2013a;Liu et al, 2013b;Pei et al, 2014;Sun et al, 2014a;Fu et al, 2015;Haryono et al, 2015;Wu et al, 2015), transcription factors (e.g. CDX2, TBX21) (Tulsyan et al, 2014;Yu et al, 2014;Iqbal et al, 2015), estrogen-related enzymes or receptors (e.g. CYP1A2, CYP19A1, ESR1) (Son et al, 2015;Sun et al, 2015b) and cell surface glycoproteins, growth factors or their receptors (e.g.…”

Section: Vietnammentioning

confidence: 99%

“…CHRNA9) (Hsieh et al, 2014), or transcription factors involved in embryonic stem cell proliferation, renewal, and pluripotency (e.g. NANOG, OCT4) (Tulsyan et al, 2014).…”

Section: Vietnammentioning

confidence: 99%

“…Interestingly, certain gene variations were associated with decreased BC risk (e.g. RAD52,OCT4,FASL,IGFIR,APE1,BARD1,IL4,IL21) (Kang et al, 2013;Liu et al, 2013a;You et al, 2013;Joshi et al, 2014b;Kang et al, 2014;Tulsyan et al, 2014;Xu et al, 2014;Wu et al, 2015), or both increased and decreased risk, depending on the gene variation investigated (e.g. MTHFR, ESR1, VEGF, FAS, OGG1, TGFB1) (Pooja et al, 2013;Kapahi et al, 2014;Lu et al, 2014;Luo et al, 2014;Wang et al, 2014c;Xu et al, 2014;Yu et al, 2014;Lu et al, 2015;Son et al, 2015).…”

Section: Non-modifiable Risk Factorsmentioning

confidence: 99%

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A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

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Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast neoplasm, epidemiology, Asia, prevalence, incidence, risk and cost of illness. Studies of any design were included, except for review articles and meta-analyses, which were excluded to avoid duplication of data. No exclusions were made based on breast cancer treatment. We reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results: A total of 776 abstracts were retrieved. After screening against the eligibility criteria, 562 abstracts were excluded. The remaining 214 abstracts, which were published between 2013 and 2015, were included in this review. Results were summarized and reported under three categories: incidence, prevalence or outcomes for breast cancer in Asia; modifiable risk factors; and non-modifiable risk factors. We found that the increased risk of breast cancer among participants from Asia was associated with older age, family history of breast cancer, early menarche, late menopause, high body mass index, being obese or overweight, exposure to tobacco smoke, and high dietary intake of fats or fatty foods. In contrast, intake of dietary fruits, vegetables, and plant-and soy-based products was associated with a decreased breast cancer risk. While based on limited data, when compared to women from the United States, women from Asia had a decreased risk of breast cancer. Conclusions: This review of 214 abstracts of studies in Asia, published between 2013 and 2015, confirmed the relevance of known non-modifiable and modifiable risk factors for women with breast cancer.

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Section: Non-modifiable Risk Factors For Breast Cancer In Asia Agesupporting

confidence: 78%

Section: Vietnammentioning

confidence: 99%

“…CHRNA9) (Hsieh et al, 2014), or transcription factors involved in embryonic stem cell proliferation, renewal, and pluripotency (e.g. NANOG, OCT4) (Tulsyan et al, 2014).…”

Section: Vietnammentioning

confidence: 99%

Section: Non-modifiable Risk Factorsmentioning

confidence: 99%

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A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

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“…Other researchers also have found that Lin28-induced chemotherapy resistance is associated with let-7, Rb, p21 and Bcl-xL, thus unraveling complicated relationship between Lin28 and tumor resistance [61, 62]. As for clinical study, by evaluating the polymorphism of Lin28 gene between breast cancer females and healthy controls, researchers have found that genetic variations in Lin28 might be a possible mechanism underlying susceptibility and clinical features in breast cancer, including the response to neoadjuvant chemotherapy [63]. …”

Section: Multiple Processes Regulated By Lin28 In Breast Cancermentioning

confidence: 99%

Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities

et al. 2017

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The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer.

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Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients*

农绍军

管杨波

王志伟

et al. 2018

Oncology and Translational Medicine

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ObjectiveRecent studies have shown abnormal expression of NANOG and IL-18 to be related to cancer. However, the molecular mechanism by which IL-18 and NANOG gene polymorphisms are associated with prostate cancer is unclear. In this study, we examined whether IL-18 and NANOG gene polymorphisms and their interaction with prostate cancer-related risk factor are associated with the susceptibility to and clinicopathological development of prostate cancer among Chinese men.MethodsPolymorphisms in the NANOG and IL-18 genes were evaluated for susceptibility in 120 patients with prostate cancer. The control group consisted of 125 samples from Chinese men. Genotyping was conducted using TaqMan allelic discrimination assays. Statistical analysis was performed using SPSS software.ResultsNo association of NANOG and IL-18 gene polymorphisms and overall prostate cancer susceptibility was detected. The IL-18-607 CC genotype was significantly associated with a higher tumor grade (P = 0.025) and stage (P = 0.001). The IL-18-137 GG genotype correlated with a higher tumor grade (P = 0.028) and stage (P = 0.008). The IL-18-137G allele was significantly more frequent in patients with lymph node metastasis (P = 0.035). The IL-18-607 CC genotype was associated with distant metastasis (P = 0.025). However, no significant association was observed between NANOG polymorphisms and any clinicopathological feature. The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors in IL-18, while IL-18 polymorphism was not. Polymorphism variants in the IL-18 (IL-18-607 and IL-18-137) and NANOG (genotypes AC) genes might be associated with a worse prognosis of patients with prostate cancer.ConclusionNANOG may be associated with the early stages of prostate cancer carcinogenesis. IL-18 and NANOG gene polymorphisms may play a major role in the growth, invasion, and metastasis of prostate cancer.

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Significant association of combination of OCT4, NANOG, and SOX2 gene polymorphisms in susceptibility and response to treatment in North Indian breast cancer patients

Abstract: Combination of genetic variants of ESCs gene may have a profound effect in breast cancer risk and response to NACT.

Cited by 12 publications

References 62 publications

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities

Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients*

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