Abstract:Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast ne… Show more
“…Although advances have been achieved in the prevention and treatment of breast cancer in recent decades, the disease remains one of the most common malignancies in women ( 1 , 2 ). It has been reported that ~1.4 million women are diagnosed as breast cancer each year all over the world, and breast cancer remains an important cause of mortality in women ( 3 , 4 ). The 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitors, also known as statins, are the most commonly use lipid-lowering medications which have become a cornerstone for the prevention and treatment of atherosclerotic cardiovascular diseases ( 5 ).…”
Background:
Statin, a lipid-lowering drug, has been suggested to confer anticancer efficacy. However, previous studies evaluating the association between statin use and prognosis in breast cancer showed inconsistent results. A meta-analysis was performed to evaluate the association between statin use and clinical outcome in women with breast cancer.
Methods:
Cohort studies comparing recurrence or disease-specific mortality in women with breast cancer with and without using of statins were identified by search of PubMed, Embase, and Cochrane's Library databases. A random-effect model, incorporating the inter-study heterogeneity, was used to combine the results. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcomes
Results:
Seventeen cohort studies with 168,700 women with breast cancer were included. Pooled results showed that statin use was significantly associated with a lower risk of breast cancer recurrence (adjusted hazard ratio [HR] = 0.72,
p
< 0.001) and breast cancer mortality (HR = 0.80,
p
< 0.001). Subgroup analysis showed that timing of statin use, statin type, study design, sample size, or quality score did not significantly affect the outcomes. However, statin use was associated with more remarkably reduced breast cancer recurrence in studies with mean follow-up duration ≤ 5 years (HR = 0.55,
p
< 0.001) than that in studies of >5 years (HR = 0.83,
p
= 0.01).
Conclusions:
Statin use is associated with reduced recurrence and disease-specific mortality in women with breast cancer. These results should be validated in randomized controlled trials.
“…Although advances have been achieved in the prevention and treatment of breast cancer in recent decades, the disease remains one of the most common malignancies in women ( 1 , 2 ). It has been reported that ~1.4 million women are diagnosed as breast cancer each year all over the world, and breast cancer remains an important cause of mortality in women ( 3 , 4 ). The 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitors, also known as statins, are the most commonly use lipid-lowering medications which have become a cornerstone for the prevention and treatment of atherosclerotic cardiovascular diseases ( 5 ).…”
Background:
Statin, a lipid-lowering drug, has been suggested to confer anticancer efficacy. However, previous studies evaluating the association between statin use and prognosis in breast cancer showed inconsistent results. A meta-analysis was performed to evaluate the association between statin use and clinical outcome in women with breast cancer.
Methods:
Cohort studies comparing recurrence or disease-specific mortality in women with breast cancer with and without using of statins were identified by search of PubMed, Embase, and Cochrane's Library databases. A random-effect model, incorporating the inter-study heterogeneity, was used to combine the results. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcomes
Results:
Seventeen cohort studies with 168,700 women with breast cancer were included. Pooled results showed that statin use was significantly associated with a lower risk of breast cancer recurrence (adjusted hazard ratio [HR] = 0.72,
p
< 0.001) and breast cancer mortality (HR = 0.80,
p
< 0.001). Subgroup analysis showed that timing of statin use, statin type, study design, sample size, or quality score did not significantly affect the outcomes. However, statin use was associated with more remarkably reduced breast cancer recurrence in studies with mean follow-up duration ≤ 5 years (HR = 0.55,
p
< 0.001) than that in studies of >5 years (HR = 0.83,
p
= 0.01).
Conclusions:
Statin use is associated with reduced recurrence and disease-specific mortality in women with breast cancer. These results should be validated in randomized controlled trials.
“… 1 Its morbidity and mortality are rising sharply in this decade. 2 In addition, with the development of modern diagnostic methods, more and more studies started focusing on the non-invasive diagnostic molecular biomarkers such as microRNAs which contributed to the metastasis of breast cancer. 3 However, the survival rate of patients carrying metastatic breast cancer has dramatically increased in recent years due to a variety of intrinsic and extrinsic factors.…”
Section: Introductionmentioning
confidence: 99%
“… 3 However, the survival rate of patients carrying metastatic breast cancer has dramatically increased in recent years due to a variety of intrinsic and extrinsic factors. 2 Besides that, the proliferation ability and highly activated cell cycle are the crucial factors contributing to metastasis of different cancers. 4 Therefore, to find the effective diagnostic and treatment method of breast cancer, there is an urgent requirement for a clearer understanding of the mechanisms associated with metastatic breast cancer at the molecular level.…”
Background
MiR-519d and miR-328-3p had tumor-regulatory properties in different cancers, but their combinatorial effects and potential common target in breast cancer had not been fully reported. This research targeted to study the underlying mechanism of how miR-519d and miR-328-3p cooperatively suppressed breast cancer.
Methods
MiR-519d and miR-328-3p expressions in breast cancer tissues and cells were assessed and Ki-67 expression was also checked. DLR assay was executed to verify whether Ki-67 was a common target of miR-519d and miR-328-3p. Western blot, flow cytometry, colony formation, wound healing and transwell assays were applied to examine the inhibitory roles of these two miRNAs on the malignant behaviors of breast cancer cells and the potential molecular mechanism.
Results
Impeded miR-519d and miR-328-3p expressions and enhanced Ki-67 expression were detected in breast cancer tissues and cells. Ki-67 was confirmed as a target of these two miRNAs. MiR-519d and miR-328-3p hampered cell proliferation and blocked cell cycle via binding to Ki-67 and they also suppressed migration and invasion. The combinatorial effects of two miRNAs were much stronger than a single miRNA.
Conclusion
Our findings proved that miR-519d and miR-328-3p played combinatorial anti-cancer roles in breast cancer by directly targeting a common target Ki-67. Our study suggested that these two miRNAs might own the potential to become novel therapeutic biomarkers involved in the diagnosis and therapy of breast cancer.
“…Breast cancer is the most common type of cancer and the leading cause of cancer death in women worldwide (1).With 1.7 million new cases per year, it accounts for 25% of all cancers in women (2).…”
Section: Introductionmentioning
confidence: 99%
“…Metastatic breast cancer, also known as advanced or stage IV breast cancer, can spread to other organs in the body, such as bone, liver, lung and brain, thus early detection of the disease can lead to best improved prognosis and long-term survival of breast cancer patients (13). A number of factors, including premature menstruation, late-onset menopause, late age at rst birth, breastfeeding period, socioeconomic status, smoking, low physical activity, obesity, and highfat diet have been associated with increased risk of breast cancer (2,14).…”
Background: Breast cancer is the most common type of cancer in women worldwide. The aim of this study was to find the subgroups of women on the basis of clustering of breast cancer risk factors. Methods: This cross sectional study was performed within the framework of Shiraz breast cancer screening program between 2004 and 2013. Clinical breast examination, mammography or sonography, fine needle aspiration or biopsy, and surgery in case of indications were performed for all participants. Also, face-to-face interviews were performed by trained staff using a structured questionnaire to collect demographic information. Latent class analysis was used to achieve study’s objectives. Results: four latent classes were indemnified; 1) general population risk (83.4% in healthy and 65.7% in diseased women), 2) moderate risk (7.8% in healthy and 20.5% in diseased women), 3) semi moderate risk [for healthy women (7.6%)] / low risk [for diseased women (8.9%)], and 4) low risk [for healthy women(0.9%)] /high risk [for diseased women(4.9%)]. This study showed that among healthy and diseased women, in the latent class 1 and 2 there was a similar pattern of breast cancer risk factors. However, in latent class 3 and 4 there were some different in the clustering of risk factors among two groups. Conclusions: Results from the present study indicated that among healthy women, 15.4% of them fell under moderate risk or semi moderate risk classes, which stresses the necessity of implementing educational and preventive intervention for this stratum of women.
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