Abstract:Based on spirometric, computed tomographic, and impulse oscillation analyses, elderly patients with asthma have greater involvement of small and large airways than nonelderly patients with asthma.
“…A comprehensive study of elderly patients with asthma in Japan demonstrated that half of the elderly patients had non‐atopic asthma, and total serum IgE levels were significantly lower than in nonelderly patients with asthma. There were no significant differences in FeNO and blood eosinophil rate, which is a finding similar to our study.…”
“…A comprehensive study of elderly patients with asthma in Japan demonstrated that half of the elderly patients had non‐atopic asthma, and total serum IgE levels were significantly lower than in nonelderly patients with asthma. There were no significant differences in FeNO and blood eosinophil rate, which is a finding similar to our study.…”
“…A recent study using IOS found that elderly patients with asthma showed higher R5, Fres, and ALX, lower R5-R20, and more negative X5 than nonelderly patients (35). Although, in those reports, R5-R20 and Xrs parameters were implicated to reflect the small airway function, it should be implicated as the overall airway including central elements.…”
The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory system resistance and reactance during tidal breathing. Recently, its clinical application has spread worldwide with the expansion of commercially available broadband frequency FOT devices, including MostGraph and Impulse Oscillometry. An increasing number of reports have supported the usefulness of the FOT in the management of asthma and chronic obstructive pulmonary disease (COPD). However, the FOT is not a surrogate test for spirometry, but should be used complementarily. Furthermore, reference values are not necessarily available and the interpretation of some measured data is controversial. There is a need to update the international statement for not only technical aspects but also the clinical use of the FOT. In this review, we summarize the previously published studies and discuss how to use the FOT in a clinical setting.
“…More recent data suggest that older patients have increased "small airway" involvement, increased neutrophilic inflammation, and decreased eosinophil function and specific antibody response compared with younger cohorts (9)(10)(11). These important, but understudied age-related changes in pulmonary function, bronchial hyperresponsiveness, host defense, and inflammation highlight the need for more investigation into this important group of patients.…”
Rationale: Age and sex are associated with differences in asthma prevalence and morbidity.Objectives: To determine if age and sex associate with distinct phenotypes and a variable response to therapy in subjects with mild to moderate asthma.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.