Sudden cardiac death and obesity

Benoit, Pascal; Sarrazin, J.; Nault, Isabelle; Poirier, Paul

doi:10.1586/14779072.2014.952283

Cited by 71 publications

(48 citation statements)

References 104 publications

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“…Regarding anthropometrics, obesity and being overweight represent a predictor of cardiac functions' impairment. A higher number of PVCs and reduced HRV have been documented in obese subjects [16]. Additionally, a recent research study identified the waist-to-hip ratio, a marker of visceral adiposity, to be associated with HRV [17].…”

Section: Introductionmentioning

confidence: 99%

Dietary and Lifestyle Patterns are Associated with Heart Rate Variability

Reginato

Azzolina

Folino

et al. 2020

JCM

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Assessment of heart rate variability (HRV) and cardiac ectopic beats is a clinically relevant topic. The present exploratory observational study aimed to inspect the relationships of lifestyle, dietary patterns, and anthropometrics with HRV, premature ventricular complexes (PVCs), and supraventricular premature complexes (SVPCs). A cross-sectional study enrolling subjects undergoing Holter monitoring was performed. Sociodemographic and clinical characteristics, body composition (full-body bio-impedentiometry), dietary patterns (validated food frequency questionnaire and 24 h dietary recall), and quality of life were assessed. Generalized additive models were estimated to evaluate the relationships between outcomes of interest and variables collected. The study enrolled 121 consecutive patients undergoing 24 h Holter monitoring. Upon univariable analysis, HRV was found to have an inverse association with mass of body fat (MBF) (p-value 0.015), while doing physical activity was associated with a significantly higher HRV (p-value 0.036). Upon multivariable analysis, fruit consumption in the 24 h dietary recall was found to be directly associated with HRV (p-value 0.044). The present findings might be useful for improving the management of patients attending cardiac rhythm labs, and to tailor ad hoc prevention strategies (modification of lifestyle and eating habits) based on Holter parameters.

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Section: Introductionmentioning

confidence: 99%

Dietary and Lifestyle Patterns are Associated with Heart Rate Variability

Reginato

Azzolina

Folino

et al. 2020

JCM

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“…Obesity is associated with an increased risk for cardiovascular diseases and premature death [1,2]. An abnormal ventricular repolarization, which predisposes to sudden death upon cardiac arrhythmia [3], may contribute to the increased mortality risk since obesity has been found to be associated with a high prevalence of a prolonged QT interval in electrocardiographic (ECG) recordings [4].…”

Section: Introductionmentioning

confidence: 99%

QT Interval Shortening After Bariatric Surgery Depends on the Applied Heart Rate Correction Equation

et al. 2016

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Background A shortening of electrocardiographic QT interval has been observed in obese subjects after weight loss, but previous results may have been biased by inappropriate heart rate (HR) correction. Methods Electrocardiography (ECG) recordings of 49 (35 females) severely obese patients before and 12 months after Roux-en-Y gastric bypass (RYGB) surgery were analysed. QT interval (QTc) was calculated by using four different equations, i.e. Bazett, Fridericia, Framingham and Hodges. Results Irrespectively of the used correction formula, QTc interval length was reduced after the surgery (QTc Bazett −31 ± 18 ms; QTc Fridericia −12 ± 15 ms; QTc Framingham −14 ± 15 ms; QTc Hodges −9 ± 15 ms; all Ps < 0.001), but QTc Bazett reduction was significantly greater than the reduction in QTc calculated upon the other three equations (all Ps < 0.001). Moreover, changes in QTc Bazett (P < 0.001) but not in QTc Fridericia , QTc Framingham and QTc Hodges (all Ps > 0.05) were significantly correlated with concurrent changes in HR. Multivariate regression analyses revealed a significant independent association of serum insulin levels with QTc Fridericia , QTc Framingham and QTc Hodges values (all Ps < 0.05) preoperatively, whilst changes in QTc interval length after the surgery were not consistently associated to concurrent changes in metabolic traits. Conclusions Our data show that the extent of weight lossassociated QTc interval shortening largely depends on the applied HR correction equation and appears to be overestimated when the most popular Bazett's equation is used.

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“…increased risk of atrial and ventricular arrhythmias. 10,11 Furthermore, several studies suggested that obesity per se was associated with an increased risk of SCD. 12,13 In the Atherosclerosis Risk in Communities study, 12 obesity was related to the incidence of SCD over a 12.6 year follow-up.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Effect of Cardiorespiratory Fitness on Risk of Sudden Cardiac Death in Overweight/Obese Men Aged 42 to 60 Years

Jae

Franklin

Kurl

et al. 2018

The American Journal of Cardiology

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The purpose of this study was to examine the subject and combined associations of cardiorespiratory fitness (fitness) and body mass index (BMI) with the risk of sudden cardiac death (SCD) in middle-aged men. This prospective study was based on a population sample of 2,357 men aged 42 to 60 years, who were followed up in the Kuopio Ischemic Heart Disease cohort study. Fitness was directly measured by peak oxygen uptake (VO) during progressive exercise testing to volitional fatigue. Participants were divided into 4 groups (fit-normal weight, unfit-normal weight, fit-overweight/obese, and unfit-overweight/obese) based on the median values of fitness and BMI. A total of 253 (10.7%) SCDs occurred during an average follow-up of 22 years. After adjusting for potential confounders, the hazard ratio (HR) and 95% confidence interval (CI) for SCD was 1.80 (95% CI 1.21 to 2.68) for BMI ≥30.0 kg/m versus normal weight cohort, that is, BMI corresponding to 18.5 to 24.9 kg/m. However, these associations were no longer statistically significant after adjusting for VO (1.49, 95% CI 0.98 to 2.24). Compared with the lower levels of fitness, upper levels of fitness had a 39% lower risk of SCD (HR 0.61, 95% CI 0.40 to 0.92) after adjusting for potential confounders, including BMI. In the combined associations of fitness and BMI with the risk of SCD, unfit-overweight/obese men had 1.80 times (95% CI 1.06 to 3.06) increased risk of SCD, but fit-overweight/obese men were not at increased risk of SCD (HR 1.22, 95% CI 0.66 to 2.25) as compared with their fit-normal weight counterparts. In conclusion, both overweight/obesity and fitness were independently associated with the risk of SCD; however, fitness appears to attenuate the risk of SCD in overweight/obese men, suggesting that improving fitness may reduce the risk of SCD in this population.

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Sudden cardiac death and obesity

Cited by 71 publications

References 104 publications

Dietary and Lifestyle Patterns are Associated with Heart Rate Variability

Dietary and Lifestyle Patterns are Associated with Heart Rate Variability

QT Interval Shortening After Bariatric Surgery Depends on the Applied Heart Rate Correction Equation

Effect of Cardiorespiratory Fitness on Risk of Sudden Cardiac Death in Overweight/Obese Men Aged 42 to 60 Years

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