Effect of Cardiorespiratory Fitness on Risk of Sudden Cardiac Death in Overweight/Obese Men Aged 42 to 60 Years

Jae, Sae Young; Franklin, Barry A.; Kurl, Sudhir; Fernhall, Bo; Kunutsor, Setor K; Kauhanen, Jussi; Laukkanen, Jari A.

doi:10.1016/j.amjcard.2018.05.017

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…Heffernan and Loprinzi 4 concluded that maintaining higher CRF and lower body fat promotes healthy vascular aging, whereas the coexistence of lower CRF and high levels of obesity may accelerate vascular aging. Recently, Jae et al 8 reported that overweight/obesity and low levels of CRF were independently associated with the increased risk of sudden cardiac death in men; however, higher fitness appeared to attenuate this risk even in overweight/obese men. Collectively, these findings highlight the importance of improving CRF to attenuate the negative impact of obesity on vascular aging, which may ultimately confer a reduction in the risk of CVD events.…”

Section: Background and Study Overviewmentioning

confidence: 99%

Low Fitness and High Fatness: The "Double Whammy" on Vascular Health

Craig

Bunsawat

2021

KJSM

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Section: Background and Study Overviewmentioning

confidence: 99%

Low Fitness and High Fatness: The "Double Whammy" on Vascular Health

Craig

Bunsawat

2021

KJSM

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The role of cardiorespiratory fitness on the risk of sudden cardiac death at the population level: A systematic review and meta-analysis of the available evidence

Jiménez-Pavón¹,

Lavie²,

Blair³

2019

Progress in Cardiovascular Diseases

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Cardiorespiratory fitness (CRF) has been widely studied as a powerful and independent predictor of all-cause and disease-specific mortality. Sudden cardiac death (SCD) is recognized as a significant cause of mortality among the general population, including the general population without previous symptoms of any coronary heart disease (CHD). Consequently, SCD is an important public health problem, which constitutes a clinical challenge. Thus, prevention of SCD by detecting early risk factors could be a useful tool, contributing to the American Heart Association's goal of decreasing the incidence of SCD at the population level. The identification of these risk factors for CVD would facilitate the large-scale screening of those participants at higher risk of SCD. This systematic review collects information about the role of CRF on the risk of SCD at the available evidence, and analyzes the long-term influence of CRF as a risk factor and independent predictor of SCD.

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Physical activity and the risk of sudden cardiac death: a systematic review and meta-analysis of prospective studies

Aune

Schlesinger

Hamer

et al. 2020

BMC Cardiovasc Disord

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Background: Physical activity has been associated with a significant reduction in risk of sudden cardiac death in epidemiological studies, however, the strength of the association needs clarification. We conducted a systematic review and meta-analysis to summarize the available data from population-based prospective studies. Methods: PubMed and Embase databases were searched for studies of physical activity and sudden cardiac death from inception to March 26th 2019. Prospective studies reporting adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of sudden cardiac death associated with physical activity were included. A random effects model was used to estimate summary RRs (95% CIs). Results: Thirteen prospective studies were included in the systematic review. Eight prospective studies with 1193 sudden cardiac deaths among 136,298 participants were included in the meta-analysis of physical activity and sudden cardiac death and the summary RR for highest vs. lowest level of physical activity was 0.52 (95% CI: 0.45-0.60, I 2 = 0%, p heterogeneity = 0.72). The association was similar in men and women and among American and European studies. In the dose-response analysis the summary RR was 0.68 (95% CI: 0.55-0.86, I 2 = 44%, n = 3) per 20 MET-hours/week. Although the test for nonlinearity was not significant, p nonlinearity = 0.18, there was no further reduction in risk beyond 20-25 MET-hours/week. The summary RR was 0.58 (95% CI: 0.41-0.81, I 2 = 0%, p heterogeneity = 0.65, n = 2) for the highest vs. the lowest level of cardiorespiratory fitness. Conclusion: This meta-analysis suggest that a high compared to a low level of physical activity may reduce the risk of sudden cardiac death in the general population. Further studies are needed to clarify the dose-response relationship between specific subtypes and intensities of physical activity in relation to sudden cardiac death.

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Effect of Cardiorespiratory Fitness on Risk of Sudden Cardiac Death in Overweight/Obese Men Aged 42 to 60 Years

Cited by 5 publications

References 22 publications

Low Fitness and High Fatness: The "Double Whammy" on Vascular Health

Low Fitness and High Fatness: The "Double Whammy" on Vascular Health

The role of cardiorespiratory fitness on the risk of sudden cardiac death at the population level: A systematic review and meta-analysis of the available evidence

Physical activity and the risk of sudden cardiac death: a systematic review and meta-analysis of prospective studies

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