Mutations of Novel Influenza A(H10N8) Virus in Chicken Eggs and MDCK Cells

Yang, Jian; Zhang, Ting; Guo, Li; Hu, Yongfeng; Li, Jinlin; Su, Haoxiang; Ren, Xianwen; Dong, Jie; Sun, Lu; Xiao, Yan; Li, Li; Yang, Fan; Wang, Jianwei; Yuan, Hui; Jin, Qi

doi:10.3201/eid2009.140257

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…Recently, three H10N8 isolates from Nanchang City were reported2021, two belong to genotype JX/346 and one is Ev/JX/23930 according to our analysis. The findings further supported that the diversified H10N8 virus circulated in the poultry in Nanchang City.…”

Section: Discussionmentioning

confidence: 60%

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Genetic Diversity of Avian Influenza A (H10N8) Virus in Live Poultry Markets and Its Association with Human Infections in China

Liu

Yuan

et al. 2015

Sci Rep

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Following the first human infection with the influenza A (H10N8) virus in Nanchang, China in December 2013, we identified two additional patients on January 19 and February 9, 2014. The epidemiologic, clinical, and virological data from the patients and the environmental specimen collected from 23 local live poultry markets (LPMs) were analyzed. The three H10N8 cases had a history of poultry exposure and presented with high fever (>38°C), rapidly progressive pneumonia and lymphopenia. Substantial high levels of cytokines and chemokines were observed. The sequences from an isolate (A/Environment/Jiangxi/03489/2013 [H10N8]) in an epidemiologically linked LPM showed highly identity with human H10N8 virus, evidencing LPM as the source of human infection. The HA and NA of human and environmental H10N8 isolates showed high identity (99.1–99.9%) while six genotypes with internal genes derived from H9N2, H7N3 and H7N9 subtype viruses were detected in environmental H10N8 isolates. The genotype of the virus causing human infection, Jiangxi/346, possessed a whole internal gene set of the A/Environment/Jiangxi/10618/2014(H9N2)-like virus. Thus, our findings support the notion that LPMs can act as both a gene pool for the generation of novel reassortants and a source for human infection, and intensive surveillance and management should therefore be conducted.

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Section: Discussionmentioning

confidence: 60%

“…Star (*) represents that the viruses were from currently-published reports2021. Minus (−) represents no definition was used for H9N2.…”

Section: Figurementioning

confidence: 99%

Genetic Diversity of Avian Influenza A (H10N8) Virus in Live Poultry Markets and Its Association with Human Infections in China

Liu

Yuan

et al. 2015

Sci Rep

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“…The patient deteriorated rapidly and died 9 days after illness onset. It was the first human infection of avian-origin H10N8 and no poultry outbreak by this subtype of influenza virus has been reported previously, except for an H10N8 influenza virus, which was isolated from Dongting Lake wetlands in 2007 [74,75].…”

Section: Subtype H7n9mentioning

confidence: 99%

Veterinary Influenza Vaccines Against Avian Influenza in China

Fan¹,

Hu²,

Zhang³

et al. 2015

Future Virol.

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Avian influenza (AI) is an infectious viral illness that affects numerous species of birds, including chickens, ducks, turkeys and geese. Poultry vaccination plays an important role for control of the AI virus and effectively prevents the infection in domestic chickens. However, new, increasingly virulent strains are constantly emerging, for which no vaccines are available. Avian influenza is also responsible for sporadically infecting humans and causing a wide range of clinical outcomes. Here, we review the recent emergence of diverse strains of the AI virus and the use of veterinary vaccines for poultry in China.

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“…Because laboratory culture of influenza viruses requires sufficient biosecurity levels, the final subtyping may be delayed for days to weeks. Next-generation sequencing (NGS) technologies have been successfully applied to obtain full genomes of newly emergent influenza A viruses directly from clinical samples [1][2][3] and do not require high biosafety qualifications. Hence, it is promising to equip NGS technologies in hospitals to greatly improve the speed and quality of clinical influenza surveillance.…”

mentioning

confidence: 99%

“…We collected sputum specimens from two patients, respectively infected by influenza A (H7N9) and (H10N8) viruses [1,2]. Total RNAs were extracted and amplified by sequence-independent PCR for each specimen [4], then divided into two pieces and subject to sequencing with Ion Torrent PGM and MiSeq, respectively.…”

mentioning

confidence: 99%