Veterinary Influenza Vaccines Against Avian Influenza in China

Fan, Xiaohu; Hu, Yanxin; Zhang, Guozhong; Wang, Ming

doi:10.2217/fvl.15.23

Cited by 6 publications

(9 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the course of 10 years, the control of H5N1 in China has required the introduction of seven different killed vaccines. In addition, H5N1 has also been combined with H9N2 for better vaccination coverage, adding two new killed vaccine formulations ( Fan et al ., 2015 ). In 2017, a vaccine combining H7N9 with H5N1 was approved for use in poultry ( Shi et al ., 2018 ).…”

Section: Ai Vaccines and Vaccinationmentioning

confidence: 99%

“…In 2017, a vaccine combining H7N9 with H5N1 was approved for use in poultry ( Shi et al ., 2018 ). The need for the regular updating of H5N1 viral subtypes is also required for live recombinant NDV-vectored vaccines, with three different formulations (rLH5-1, rLH5-5 and rLH5-6) approved since 2005 ( Fan et al ., 2015 ). The need for regular updating of vaccinal strains was also reported by Tarigan et al .…”

Section: Ai Vaccines and Vaccinationmentioning

confidence: 99%

See 1 more Smart Citation

Are current avian influenza vaccines a solution for smallholder poultry farmers?

Guyonnet

Peters

2020

Gates Open Res

View full text Add to dashboard Cite

Vaccination against highly pathogenic avian influenza (HPAI) viruses, along with other measures, was successful in eradicating AI in very few countries where the competence of national veterinary services or the geography and bird density have contributed favorably to the outcome. The main constraints to an effective AI vaccination are vaccine composition matching field strains, reliable cold chain and logistics to target all poultry smallholders, constraints related to the availability of sufficient financial and human resources. When not conducted properly, vaccination can also contribute to the emergence of new field viral strains, through genetic drifts of HPAI viruses. While new technologies have improved the possibility to produce high quality vaccines matching field strains, recurrent issues like post-vaccination field surveillance and vaccination coverage continue to limit the relevance of AI vaccination in smallholder settings. A “game-changer” vaccine targeting smallholders should be universal to protect against all field viral strains and reduce significantly, if not totally eliminate, the need for costly post-vaccination surveillance. The ease of administration of this vaccine (eye drop or one single injection) would further contribute to its relevance in the field. These characteristics are considered essential for the product profile of an AI vaccine that can contribute in a meaningful way to the livelihoods of poultry smallholders.

show abstract

Section: Ai Vaccines and Vaccinationmentioning

confidence: 99%

Section: Ai Vaccines and Vaccinationmentioning

confidence: 99%

Are current avian influenza vaccines a solution for smallholder poultry farmers?

Guyonnet

Peters

2020

Gates Open Res

View full text Add to dashboard Cite

show abstract

“…The H7N7 genotype was implicated in the 2003 epizootic in the Netherlands [ 19 ]. Over the past two decades, the H5N2 and H9N2 subtypes had been implicated in several outbreaks in China [ 10 ].…”

Section: Avian Influenza Viruses (Aivs)mentioning

confidence: 99%

“…Highly pathogenic AI (HPAI) viruses (HPAIVs) cause severe and fatal disease with up to 100% mortality in infected poultry [ 7 , 8 ]. Past epizootics such as those that occurred in Southeast Asia [ 9 ], China [ 10 ], and West Africa [ 8 ] had shown that even LPAI viruses such as H9N2 strains caused a mortality rate of up to 60 in affected chicken flocks [ 11 ]. The continued prevalence of these viruses in birds is inevitably threatening food security by lowering the production of poultry products for local consumption and export.…”

Section: Introductionmentioning

confidence: 99%

Virus-like Particle Vaccines: A Prospective Panacea Against an Avian Influenza Panzootic

Ninyio

Omar

et al. 2020

Vaccines

View full text Add to dashboard Cite

Epizootics of highly pathogenic avian influenza (HPAI) have resulted in the deaths of millions of birds leading to huge financial losses to the poultry industry worldwide. The roles of migratory wild birds in the harbouring, mutation, and transmission of avian influenza viruses (AIVs), and the lack of broad-spectrum prophylactic vaccines present imminent threats of a global panzootic. To prevent this, control measures that include effective AIV surveillance programmes, treatment regimens, and universal vaccines are being developed and analysed for their effectiveness. We reviewed the epidemiology of AIVs with regards to past avian influenza (AI) outbreaks in birds. The AIV surveillance programmes in wild and domestic birds, as well as their roles in AI control were also evaluated. We discussed the limitations of the currently used AI vaccines, which necessitated the development of a universal vaccine. We evaluated the current development of AI vaccines based upon virus-like particles (VLPs), particularly those displaying the matrix-2 ectodomain (M2e) peptide. Finally, we highlighted the prospects of these VLP vaccines as universal vaccines with the potential of preventing an AI panzootic.

show abstract

“…There have been cases of mass infection of livestock by malignant pathogens such as avian influenza (AI) [4] and foot and mouth disease (FMD). These pathogens are highly contagious and deadly to poultry and pigs [5,6], and can survive for a considerably long period at room temperature and even under sub-zero conditions [7]. Thus, it is of paramount importance to introduce and use appropriate management approaches to combat and to avoid the potential health risks derived from increasing concentration of livestock production and related concentration of livestock manure within a geographic area [7,8].…”

Section: Ofmentioning

confidence: 99%

Composting Reduces the Vitality of H9N2 in Poultry Manure and EMCV in Pig Manure Allowing for an Environmentally Friendly Use of These Animal Wastes: A Preliminary Study

Jeong

Lee

et al. 2020

Microorganisms

View full text Add to dashboard Cite

In our study, we monitored the inactivation of two important viruses that are critical in animal husbandry throughout the world. To evaluate the influence of the composting process on inactivation of avian influenza virus (H9N2) in poultry manure compost (PMC) and Encephalomyocarditis virus (EMCV) in pig (swine) manure compost (SMC), the H9N2 and EMCV were injected in dialysis cassettes and buried in two different manure compost piles of poultry and pig manure, respectively. The highest temperature achieved in the PMC and SMC piles during the test period were 75 °C and 73.5 °C, respectively. At the completion of the composting for 168 h, inactivation effect appeared to be more sensitive in H9N2 than EMCV. The vitality of H9N2 decreased by 6.25 ± 0.35 log10TCID50/mL to 0.0 log10TCID50/mL within 1 h of the composting. The vitality of EMCV decreased from 7.75 ± 0.35 log10TCID50/mL to 1.50 log10TCID50/mL within 24 h of starting the composting process. However, the activation of EMCV was not decreased (from 7.75 ± 0.35 to 7.50 ± 0.71 log10TCID50/mL) in the control treatment (not inserted in composts) after 168h, while the activation of H9N2 in dialysis cassettes was significantly decreased (from 6.25 ± 0.35 log10TCID50/mL to 2.00 ± 0.6 log10TCID50/mL). Our study demonstrated the effectiveness of the composting treatment in inactivating the viruses studied, which was not the case with air treatment.

show abstract

Veterinary Influenza Vaccines Against Avian Influenza in China

Cited by 6 publications

References 78 publications

Are current avian influenza vaccines a solution for smallholder poultry farmers?

Are current avian influenza vaccines a solution for smallholder poultry farmers?

Virus-like Particle Vaccines: A Prospective Panacea Against an Avian Influenza Panzootic

Composting Reduces the Vitality of H9N2 in Poultry Manure and EMCV in Pig Manure Allowing for an Environmentally Friendly Use of These Animal Wastes: A Preliminary Study

Contact Info

Product

Resources

About