Smoking, MATRICS consensus cognitive battery and P50 sensory gating in a Han Chinese population

Tan, Shuping; Cui, Jiefeng; Fan, Fengmei; Zhao, Yanli; Chen, Nan; Fan, Hongzhen; Zhang, Jinguo; Wang, Yunhui; Yoon, Jin Ho; Soares, Jair C.; Zou, Yue; Zhang, Xiang Yang

doi:10.1016/j.drugalcdep.2014.06.045

Cited by 21 publications

(4 citation statements)

References 70 publications

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“…The classical auditory paired-stimulus paradigm was used in our previous studies (Tan et al, 2014). The auditory paired-stimulus paradigm (S1 and S2) was also introduced in this study, and 60 paired clicks were delivered binaurally through headphones.…”

Section: Methodsmentioning

confidence: 99%

Abnormal Entropy Modulation of the EEG Signal in Patients With Schizophrenia During the Auditory Paired-Stimulus Paradigm

Xiang

Niu

Yan

et al. 2019

Front. Neuroinform.

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The complexity change in brain activity in schizophrenia is an interesting topic clinically. Schizophrenia patients exhibit abnormal task-related modulation of complexity, following entropy of electroencephalogram (EEG) analysis. However, complexity modulation in schizophrenia patients during the sensory gating (SG) task, remains unknown. In this study, the classical auditory paired-stimulus paradigm was introduced to investigate SG, and EEG data were recorded from 55 normal controls and 61 schizophrenia patients. Fuzzy entropy (FuzzyEn) was used to explore the complexity of brain activity under the conditions of baseline (BL) and the auditory paired-stimulus paradigm (S1 and S2). Generally, schizophrenia patients showed significantly higher FuzzyEn values in the frontal and occipital regions of interest (ROIs). Relative to the BL condition, the normalized values of FuzzyEn of normal controls were decreased greatly in condition S1 and showed less variance in condition S2. Schizophrenia patients showed a smaller decrease in the normalized values in condition S1. Moreover, schizophrenia patients showed significant diminution in the suppression ratios of FuzzyEn, attributed to the higher FuzzyEn values in condition S1. These results suggested that entropy modulation during the process of sensory information and SG was obvious in normal controls and significantly deficient in schizophrenia patients. Additionally, the FuzzyEn values measured in the frontal ROI were positively correlated with positive scores of Positive and Negative Syndrome Scale (PANSS), indicating that frontal entropy was a potential indicator in evaluating the clinical symptoms. However, negative associations were found between the FuzzyEn values of occipital ROIs and general and total scores of PANSS, likely reflecting the compensation effect in visual processing. Thus, our findings provided a deeper understanding of the deficits in sensory information processing and SG, which contribute to cognitive deficits and symptoms in patients with schizophrenia.

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Section: Methodsmentioning

confidence: 99%

Abnormal Entropy Modulation of the EEG Signal in Patients With Schizophrenia During the Auditory Paired-Stimulus Paradigm

Xiang

Niu

Yan

et al. 2019

Front. Neuroinform.

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“…Several studies reported significant impairment in each of the seven MCCB domains in SZ patients compared to healthy controls (HC) [13–15]. After the MCCB was translated into Chinese, the clinical reliability and validity of MCCB were established between SZ patients and HC [16] to allow for its widespread use in cognitive research in SZ patients in China [17–19].…”

Section: Introductionmentioning

confidence: 99%

Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study

et al. 2019

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BackgroundCognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients.MethodA total of 104 participants (44 SZ patients and 60 age- and gender-matched healthy controls (HC)) were recruited for this study. The MCCB was used to assess cognitive function of the participants, while brain activity was assessed using the ALFF. The relationship between the MCCB and the ALFF was investigated by using a correlation analysis.ResultsThere were significant differences between SZ patients and HC in MCCB total and domain scores as well as in ALFF results. The reduction of ALFF in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MCCB sub-test of symbol coding.ConclusionThese findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1992-4) contains supplementary material, which is available to authorized users.

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“…In recent years, MCCB for cognitive measurement has been translated into Chinese, and its clinical validity and test-retest reliability have been established between schizophrenia patients and health controls 19 . The MCCB has been applied in cognition studies for schizophrenia patients in Chinese population 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%

Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients

Zhang

Han

Tan

et al. 2017

Sci Rep

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Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive functions can significantly affect the outcomes and daily life in patients. This study examined the gender differences of cognition using the measurement and treatment research to improve cognition in schizophrenia (MATRICS) consensus cognitive battery (MCCB), especially focusing on reasoning and problem solving, and social cognition in schizophrenia patients. The results showed that healthy controls exemplified better cognition than patients in both genders in all examined MCCB scores. Male healthy controls had better reasoning and problem solving and working memory than females, but these gender differences were not presented in schizophrenia patients. Also, male schizophrenia patients showed worse cognition than females on social cognition, processing speed, verbal learning and visual learning. Our results support that male schizophrenia patients had more cognitive impairment than females on reasoning and problem solving, social cognition, processing speed, working memory, verbal learning and visual learning.

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Smoking, MATRICS consensus cognitive battery and P50 sensory gating in a Han Chinese population

Cited by 21 publications

References 70 publications

Abnormal Entropy Modulation of the EEG Signal in Patients With Schizophrenia During the Auditory Paired-Stimulus Paradigm

Abnormal Entropy Modulation of the EEG Signal in Patients With Schizophrenia During the Auditory Paired-Stimulus Paradigm

Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study

Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients

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