Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study

Abstract

BackgroundCognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients.MethodA total of 104 participants (44 SZ patients and 60 age- and gender-matched healthy controls (HC)) were recruited for this study. The MCCB was used to assess cognitive function of the participants, while brain activity was assessed using the ALFF. The relationship between the MCCB and the ALFF was investigated by using a correlation analysis.ResultsThere were significant differences between SZ patients and HC in MCCB total and domain scores as well as in ALFF results. The reduction of ALFF in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MCCB sub-test of symbol coding.ConclusionThese findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1992-4) contains supplementary material, which is available to authorized users.

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

“…In the present study, the dn-FES group showed severe and widespread cognitive deficits in all domains, and this observation was consistent with previous studies that used the same instrument [33][34][35]. Schizophrenia has distinct cognitive impairments, including speed of processing [36], working memory [37], verbal learning [38], reasoning/problem solving [39], visual learning [40], attention/vigilance [41], and social cognition [42].…”

“…MCCB has been used widely in China since its clinical reliability and validity were established [5]. Patients with schizophrenia show significant cognitive deficits across multiple cognitive domains [6][7][8].…”

SLC40A1 mediates ferroptosis and cognitive dysfunction in type 1 diabetes

“…A decrease in ALFF indicates that the spontaneous activity of neurons in the corresponding brain area is weakened and structure function is impaired. In contrast, increase in ALFF indicates enhanced brain activity [28,29]. In our study, ALFF signals in the hippocampus and anterior cingulate cortex of type 1 diabetic rats were reduced, indicating that these central neurons related to learning and memory activity were weakened.…”

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

“…Consensus Cognitive Battery (MCCB) is a standard cognitive battery and contains ten tests that measure seven cognitive domains: speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition [3,4]. Patients with SZ show significant cognitive deficits across multiple cognitive domains assessed with the MCCB [5][6][7][8][9].…”