An observational study of inflammation in the central nervous system in patients with bipolar disorder

Stich, Oliver; T, Andres; Gross, Claus M.; Gerber, Sonja; Rauer, Sebastian; Langosch, Jens M.

doi:10.1111/bdi.12244

Cited by 39 publications

(47 citation statements)

References 34 publications

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“… 4 – 6 , 8 The patient reported here had no history of being treated with immunosuppressants. His blood examination showed normal cell count despite of the presence of anti-CMV IgG and anti-HSV-II IgM in CSF, which is in accordance with the reported evidence for increased production of antibodies against several neurotropic infectious pathogens including HSV-I, HSV-II, and CMV, in the CSF of individuals with bipolar disorder 9 or autism spectrum disorders. 10 , 11 The mild signs of CNS inflammation in this patient may account for the absence of seizures and focal neurological signs although he presented primarily acute psychotic symptoms and mental status changes.…”

Section: Discussionsupporting

confidence: 88%

Double encephalitis with herpes simplex virus type II and cytomegalovirus in an elder Chinese: a case report

Xue¹,

et al. 2015

NDT

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Herpes simplex encephalitis is a rare disease. In adults, most of the reported cytomegalovirus (CMV) infections are seen in immunocompromised patients. We present a case of 67-year-old Chinese male with the coinfection of CMV and herpes simplex virus type II (HSV-II). He had no history of being treated with immunosuppressants, showed symptoms of psychosis and was scored 109 on the Positive and Negative Syndrome Scale. This patient presented with a rare case of coinfection of CMV and herpes simplex virus type II with psychotic symptoms.

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Section: Discussionsupporting

confidence: 88%

Double encephalitis with herpes simplex virus type II and cytomegalovirus in an elder Chinese: a case report

Xue¹,

et al. 2015

NDT

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“…The patient described here had no history of being treated with immunosuppressive therapy. Although CSF had a fairly high cytosis, her blood examination showed normal cell count despite the presence of anti-VCA EBV IgG and anti-HSV-1/2 IgG in CSF, which is in accordance with the reported evidence for increased production of antibodies against several neurotropic pathogens including HSV-1/2, in the CSF of patients with bipolar disorder or autism spectrum disorders [10,11]. The absence of seizures and rough focal neurological signs characteristic of Herpes simplex encephalitis (HSE) confirm a mild process flow in the patient.…”

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confidence: 89%

Acute Human Herpesvirus-7-associated Encephalitis in a Young Adult Coinfected with Herpes Simplex Virus -1/2 and Epstein-Barr Virus

Dyachenko¹

2017

INDJ

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Background: Herpesvirus encephalitis (HVE) is a serious threat to people's health and life. The most common cause of these is herpes simplex virus. On the contrary, only isolated cases of encephalitis associated with herpesvirus type 7 are described. Objective: To describe a case of acute encephalitis in a young adult caused by uncommon Human herpesvirus 7 (HHV-7), underlying with Herpes simplex virus 1/2 (HSV-1/2) and Epstein-Barr virus (EBV) coinfection. Results: A 20-years-old woman presented to The Center of Infectious Disorders of the Nervous System (Kyiv, Ukraine) after developing acute fever followed by a left side partial loss of hearing. Her physical examination showed slow mentation and generalized weakness. Cerebrospinal fluid (CSF) analysis revealed pleocytosis of 15 cell/µl (45% lymphocytes, 55% granulocytes), and HHV-7 DNA (3.35 log genome copies per ml). CSF also contained IgG antibodies against HSV-1/2 and EBV capsid antigen (CA). No HHVs DNA nor antibodies to viral proteins were detected in the blood. Areas of mild increased signal in parietal lobes were detected on an MRI brain scan. After treating with Ganciclovir the patient was discharged in good condition. Conclusion: The author presents a case of primary HHV-7 infection followed acute encephalitis Case Study

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“…Another study found increased lactate levels in 5 out of 15 patients with bipolar disorder [ 13 ]. In an earlier study, we detected a synthesis of polyspecific, intrathecal antibodies against different neurotropic infectious pathogens ( Toxoplasma gondii , Herpes simplex virus types 1/2, cytomegalovirus, and Epstein–barr virus) in some patients with bipolar disorders [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Do patients with schizophreniform and bipolar disorders show an intrathecal, polyspecific, antiviral immune response? A pilot study

Endres

Huzly

Dersch

et al. 2017

Fluids Barriers CNS

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BackgroundWe previously described inflammatory cerebrospinal fluid (CSF) alterations in a subgroup of patients with schizophreniform disorders and the synthesis of polyspecific intrathecal antibodies against different neurotropic infectious pathogens in some patients with bipolar disorders. Consequently, we have measured the prevalence of a positive MRZ reaction (MRZR)—a marker for a polyspecific, antiviral, intrathecal, humoral immune response composed of three antibody indices for the neurotropic viruses of measles (M), rubella (R), and varicella zoster (Z)—in these patients.MethodsWe analyzed paired CSF and serum samples of 39 schizophreniform and 39 bipolar patients. For comparison, we used a group of 48 patients with other inflammatory neurological disorders (OIND) and a cohort of 203 multiple sclerosis (MS) patients.ResultsWe found a positive MRZR in two patients with schizophreniform disorders (5.1%); both suffered from schizodepressive disorders without any other signs suggestive of MS. None of the bipolar patients (0%) and four members of the OIND group (8.3%) showed a positive MRZR. In the MS cohort, a positive MRZR was found significantly more frequently [in 99 patients (48.8%)] than in the other patient groups (p > 0.001). In summary, we did not find a positive MRZR in a relevant subgroup of patients with schizophreniform or bipolar disorders.ConclusionsOur results indicate that the MRZR is highly specific to MS. Nevertheless, two schizodepressive patients also had a positive MRZR. This finding corresponds to the few MRZR-positive patients with OIND or other autoimmune disorders with central nervous involvement, implicating that the MRZR specificity for MS is high, but not 100%.

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An observational study of inflammation in the central nervous system in patients with bipolar disorder

Cited by 39 publications

References 34 publications

Double encephalitis with herpes simplex virus type II and cytomegalovirus in an elder Chinese: a case report

Double encephalitis with herpes simplex virus type II and cytomegalovirus in an elder Chinese: a case report

Acute Human Herpesvirus-7-associated Encephalitis in a Young Adult Coinfected with Herpes Simplex Virus -1/2 and Epstein-Barr Virus

Do patients with schizophreniform and bipolar disorders show an intrathecal, polyspecific, antiviral immune response? A pilot study

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