Fabrication of carbon nanotube—polyimide composite hollow microneedles for transdermal drug delivery

Lyon, Bradley J.; Aria, Adrianus Indrat; Gharib, Morteza

doi:10.1007/s10544-014-9892-y

Cited by 32 publications

(31 citation statements)

References 30 publications

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“…There is also a report in the literature on a novel method for fabricating HM using a composite of vertically-aligned carbon nanotubes and polyimide [ 18 ]. Patterned bundles of carbon nanotubes were used as a porous scaffold for defining the MN geometry.…”

Section: Hollow Microneedlesmentioning

confidence: 99%

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

2015

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Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. Microneedles can be used to enhance transdermal drug delivery. In this review, different types of microneedles are described and their methods of fabrication highlighted. Microneedles can be fabricated in different forms: hollow, solid, and dissolving. There are also hydrogel-forming microneedles. A special attention is paid to hydrogel-forming microneedles. These are innovative microneedles which do not contain drugs but imbibe interstitial fluid to form continuous conduits between dermal microcirculation and an attached patch-type reservoir. Several microneedles approved by regulatory authorities for clinical use are also examined. The last part of this review discusses concerns and challenges regarding microneedle use.

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Section: Hollow Microneedlesmentioning

confidence: 99%

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

2015

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“…Hollow microneedles are made of various materials, including glass [46], nickel [140], stainless steel [14], and polymers such as SU-8 and poly-glycolic acid [55,[141][142][143][144][145], as shown in Figure 6 (a) and 6 (b). Safety of materials used for hollow microneedles are summarized in Table 6.…”

Section: Safety Of Hollow Microneedlesmentioning

confidence: 99%

Considerations in the use of microneedles: pain, convenience, anxiety and safety

Jeong

Lee

Choi

et al. 2016

Journal of Drug Targeting

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Transdermal delivery using microneedles is gaining increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. Microneedle products have recently become available on the market, and some of them are under evaluation for efficacy and safety. To be available in the market for cosmetic and therapeutic use, several factors should be considered, including pain, anxiety, convenience and safety. These factors are summarized and reviewed in this article according to type of microneedle. Various kinds of materials have been used for manufacturing microneedles and developing drug formulations for microneedles. Safety information about materials used for microneedles is summarized in terms of type of microneedles. In addition to their biocompatibility, mechanical safety is also discussed. This review can provide guidelines for designing microneedle products for proper use.

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“…Lyon et al . fabricated carbon nanotube-polyimide composite HMNs for transdermal delivery of a drug [87]. Pattern bundle of carbon nanotube was first used as a porous scaffold after which polyimide resin was wicked through for the structure and support to penetrate the skin.…”

Section: Microneedle-based Drug Delivery Systemsmentioning

confidence: 99%

Controlled Drug Delivery Using Microdevices

Sanjay

Dou

et al. 2016

CPB

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Therapeutic drugs administered systematically are evenly distributed to the whole body through blood circulation and have to cross many biological barriers before reaching the pathological site. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the urinary system resulting in suboptimal concentration of drugs at the desired site. Controlled drug delivery aims to localize the pharmacological activity of the drug to the desired site at desired release rates. The advances made by micro/nanofluidic technologies have provided new opportunities for better-controlled drug delivery. Various components of a drug delivery system can be integrated within a single tiny micro/nanofluidic chip. This article reviews recent advances of controlled drug delivery made by microfluidic/nanofluidic technologies. We first discuss microreservoir-based drug delivery systems. Then we highlight different kinds of microneedles used for controlled drug delivery, followed with a brief discussion about the current limitations and the future prospects of controlled drug delivery systems.

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Fabrication of carbon nanotube—polyimide composite hollow microneedles for transdermal drug delivery

Cited by 32 publications

References 30 publications

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

Considerations in the use of microneedles: pain, convenience, anxiety and safety

Controlled Drug Delivery Using Microdevices

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