Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome

Jędrzejuk, Diana; Łaczmański, Łukasz; Kuliczkowska, Justyna; Lenarcik, Agnieszka; Trzmiel-Bira, Anna; Hirnle, Lidia; Zaleska-Dorobisz, Urszula; Milewicz, Andrzej; Lwow, Felicja; Urbanovych, Alina; Słoka, Natalia

doi:10.3109/09513590.2014.946899

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…None of the women from the study population were on an elimination diet, suffered from chronic or systemic illness, or used lipid-and glucose-lowering drugs or oral contraceptive pills. This group was precisely described previously [9].…”

Section: Study Groupmentioning

confidence: 99%

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Pukajło

Łaczmański

Kolačkov

et al. 2015

Gynecological Endocrinology

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Irisin (Ir), a recently identified adipo-myokine, cleaved and secreted from the protein FNDC5 in response to physical activity, has been postulated to induce the differentiation of a subset of white adipocytes into brown fat and to mediate the beneficial effects on metabolic homeostasis. Metabolic syndrome (MS), a cluster of factors leading to impaired energy homeostasis, affects a significant proportion of subjects suffering from polycystic ovary syndrome (PCOS). The aim of our study was to investigate the relationship between Ir plasma concentrations and metabolic disturbances. The study group consisted of 179 PCOS patients and a population of 122 healthy controls (both groups aged 25-35 years). A subset of 90 subjects with MS was isolated. A positive association between Ir plasma level and MS in the whole group and in controls was found. In subjects with high adipose body content (>40%), Ir was higher than in lean persons (<30%). Our results showed a significant positive association between Ir concentration and android type of adipose tissue in the whole study group and in the control group. Understanding the role of Ir in increased energy expenditure may lead to the development of new therapeutics for obesity and obesity-related diseases.

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Section: Study Groupmentioning

confidence: 99%

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Pukajło

Łaczmański

Kolačkov

et al. 2015

Gynecological Endocrinology

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“…Recent studies revealed that overactivation of the endocannabinoid system is linked to insulin resistance and the progression of PCOS [ 84 , 85 ]. It has also been reported that genetic polymorphism of cannabinoids receptor 1 influences the hyperandrogenemia state in PCOS women and the development of NAFLD [ 86 , 87 ]. Antagonism of cannabinoids receptor 1 leads to the improvement of hepatic steatosis and insulin resistance [ 88 ].…”

Section: The Potential Molecular Link Between Nafld and Pcosmentioning

confidence: 99%

Prevalence, Risk Factors, and Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Women with Polycystic Ovary Syndrome (PCOS)

et al. 2022

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Background: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women’s reproductive period of life. The presence of nonalcoholic fatty liver disease NAFLD, one of the leading causes of chronic liver disease in the Western world, is increased in women with PCOS. This review aims to present current knowledge in epidemiology, pathophysiology, diagnostics, and treatment of NAFLD in PCOS with an emphasis on the molecular basis of development of NAFLD in PCOS women. Methods: Authors investigated the available data on PCOS and NAFLD by a MEDLINE and Pub Med search during the years 1990–2021 using a combination of keywords such as “PCOS”, “NAFLD”, “steatohepatitis”, “insulin resistance”, “hyperandrogenaemia”, “inflammation”, “adipose tissue”, and “obesity”. Peer-reviewed articles regarding NAFLD and PCOS were included in this manuscript. Additional articles were identified from the references of relevant papers. Results: PCOS and NAFLD are multifactorial diseases, The development of NAFLD in PCOS women is linked to insulin resistance, hyperandrogenemia, obesity, adipose tissue dysfunction, and inflammation. There is the possible role of the gut microbiome, mitochondrial dysfunction, and endocannabinoid system in the maintenance of NAFLD in PCOS women. Conclusions: There is a need for further investigation about the mechanism of the development of NAFLD in PCOS women. New data about the molecular basis of development of NAFLD in PCOS integrated with epidemiological and clinical information could influence the evolution of new diagnostic and therapeutic approaches of NAFLD in PCOS.

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“…Weight loss even by 5 % improves insulin sensitivity, concentration of SHBG, lowers testosterone level and can bring about normalization of menstrual cycle disorders, spontaneous ovulations and higher percentage of ovulations. Thus, while treating women with PCOS and without obesity, all efforts should be directed at obesity prevention [12].…”

Section: Changing a Lifestyle With Following A Healthy Dietmentioning

confidence: 99%

Modern Ways of Treatment of Metabolic Disorders in Women with Polycystic Ovarian Syndrome

Urbanovych

Kozlovska

Urbanovych

2019

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Article represents complex approach to PCOS problem from the position of prophylaxis and therapy of metabolic disorders, which include overweight and obesity, insulin resistance, carbohydrate and lipid metabolism deviations. Lifestyle modification specifically including healthy diet was provided as an example. Also, were described medications, which increase insulin sensitivity and method of treatment in case of 3rd class obesity.

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Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome

Cited by 9 publications

References 12 publications

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Prevalence, Risk Factors, and Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Women with Polycystic Ovary Syndrome (PCOS)

Modern Ways of Treatment of Metabolic Disorders in Women with Polycystic Ovarian Syndrome

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