Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Pukajło, Katarzyna; Łaczmański, Łukasz; Kolačkov, Katarzyna; Kuliczkowska-Płaksej, Justyna; Bolanowski, Marek; Milewicz, Andrzej; Daroszewski, Jacek

doi:10.3109/09513590.2015.1065482

Cited by 26 publications

(37 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown a positive correlation between Ir levels and BMI and other components of metabolic syndrome, such as systolic blood pressure, FPG level, and TG concentration [35,36]. In another study by our group, Ir was positively associated with metabolic syndrome, FPG, and BMI in relatively young women with polycystic ovarian syndrome (PCOS) [37]. Similarly, a recent study in obese children reported Ir was positively correlated with FIC, HO-MA-IR, and impaired glucose tolerance [25].…”

Section: Discussionmentioning

confidence: 54%

Growth Hormone Treatment Increases Plasma Irisin Concentration in Patients with Turner Syndrome

et al. 2016

View full text Add to dashboard Cite

Irisin (Ir) deficiency may be a contributing factor in metabolic disease. This study aimed to investigate the effect of supraphysiological doses of recombinant human growth hormone (rhGH) on Ir plasma concentration in relation to metabolic disorders, including obesity and other components of metabolic syndrome. We studied 36 girls with Turner syndrome (mean age 8.2 years) treated with rhGH (0.05 mg/kg/day). Anthropometric data and fasting blood levels [e. g., Ir, insulin, glucose, glycated hemoglobin (HbA1c), IGF-1, IGFBP-3, cholesterol, insulin resistance (HOMA-IR), and β-cell function (HOMA-β)] were analyzed prior to and following rhGH therapy [mean (SD) follow-up of 1.47 (0.89) years]. Insulin sensitivity (Matsuda index) was calculated before and after the glucose load. Following rhGH therapy, an increase in IGF-1 [mean (SD) of 119.40 (62.47) ng/ml to 439.08 (209.91) ng/ml, p=0.000], Ir [2.10 (1.03) μg/ml to 2.48 (0.78) μg/ml, p=0.036], HOMA-IR [median (IQR) of 0.64 (0.45-1.30) to 0.92 (0.67-2.36), p=0.0206], and HOMA-β values [45.00 (27.69-72.00) to 81.53 (51.43-132.00), p=0.0447] were observed. Multiple regression analysis yielded no associations between Ir and metabolic and hormonal parameters before rhGH treatment; however, on rhGH, the model (R=0.56, adjusted R0.45) showed positive associations between Ir and IGF-1 standard deviation score and HbA1c, and negative associations between Ir and fasting blood glucose, HDL-cholesterol, and triglycerides. Despite manifestation of insulin resistance, rhGH application had a positive effect on Ir regulation, and restored physiological conditions of lipid and glucose metabolism.

show abstract

Section: Discussionmentioning

confidence: 54%

Growth Hormone Treatment Increases Plasma Irisin Concentration in Patients with Turner Syndrome

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In the current study, PCOS women had similar plasma irisin concentrations in comparison to the control group. In the literature, the characterization of irisin in PCOS is quite controversial since normal (44), increased (18,21,23) and decreased (16) irisin concentrations have been described in these patients. This inconsistency may be partly due to differences in the assay methods, but it may also be due to the interference of confounding variables associated with PCOS.…”

Section: Discussionmentioning

confidence: 99%

Brown adipose tissue activity is reduced in women with polycystic ovary syndrome

Oliveira

Mamede

Bizzi

et al. 2019

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective To evaluate whether brown adipose tissue (BAT) activity is altered in women with polycystic ovary syndrome (PCOS), and whether BAT activity correlates with plasma levels of irisin, a myokine that can induce BAT formation. Design We performed a cross-sectional study including women with PCOS (n = 45) and a healthy control group (n = 25) matched by age and body mass index (BMI). Methods BAT activity was measured using 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by a validated enzyme immunoassay. Results Total BAT activity was significantly reduced in women with PCOS (maximal standardized uptake value (SUVmax): median 7.4 g/mL, interquartile range 0.9–15.4) compared to controls (median 13.0 g/mL, interquartile range 4.7–18.4, P = 0.047). However, this difference was no longer significant after adjustment for waist circumference, a surrogate marker of central adiposity. In the PCOS group, BAT activity correlated negatively with BMI (Spearman’s r = −0.630, P = 0.000) and waist circumference (r = −0.592, P = 0.000) but not with plasma irisin levels. Conclusions BAT activity was reduced in women with PCOS possibly due to increased central adiposity. In PCOS women, BAT activity did not correlate with plasma irisin levels.

show abstract

“…Other studies have since disputed the potential of irisin as a therapeutic strategy, based partly on the finding that circulating irisin levels are increased in obese patients. These discrepancies, reviewed in depth by Crujeiras et al [229], are as of yet unresolved and warrant further investigation, particularly due to the finding that irisin is also an adipokine and therefore any association with adiposity must be carefully dissociated from fat mass itself [228][229][230][231][232]. Another circulating factor, fibroblast growth factor 21 (FGF21), gained similar traction as a potential browning agent.…”

Section: Between Brown and White: An Adipocyte For All Seasonsmentioning

confidence: 99%

Thermogenic adipocytes: lineage, function and therapeutic potential

Pollard

Carling

2020

Biochemical Journal

View full text Add to dashboard Cite

Metabolic inflexibility, defined as the inability to respond or adapt to metabolic demand, is now recognised as a driving factor behind many pathologies associated with obesity and the metabolic syndrome. Adipose tissue plays a pivotal role in the ability of an organism to sense, adapt to and counteract environmental changes. It provides a buffer in times of nutrient excess, a fuel reserve during starvation and the ability to resist cold-stress through non-shivering thermogenesis. Recent advances in single-cell RNA sequencing combined with lineage tracing, transcriptomic and proteomic analyses have identified novel adipocyte progenitors that give rise to specialised adipocytes with diverse functions, some of which have the potential to be exploited therapeutically. This review will highlight the common and distinct functions of well-known adipocyte populations with respect to their lineage and plasticity, as well as introducing the most recent members of the adipocyte family and their roles in whole organism energy homeostasis. Finally, this article will outline some of the more preliminary findings from large data sets generated by single-cell transcriptomics of mouse and human adipose tissue and their implications for the field, both for discovery and for therapy.

show abstract

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Cited by 26 publications

References 31 publications

Growth Hormone Treatment Increases Plasma Irisin Concentration in Patients with Turner Syndrome

Growth Hormone Treatment Increases Plasma Irisin Concentration in Patients with Turner Syndrome

Brown adipose tissue activity is reduced in women with polycystic ovary syndrome

Thermogenic adipocytes: lineage, function and therapeutic potential

Contact Info

Product

Resources

About