Intraindividual aqueous flare comparison after implantation of hydrophobic intraocular lenses with or without a heparin-coated surface

Abstract

No author has a financial or proprietary interest in any material or method mentioned.

Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer

“…Also suppression LECs and inflammatory cells adhesion may lead to less secretion of cytokines, contributing to a relatively mild inflammatory response in IOL-P ( MPC-MAA ) group than IOL and IOL-Plasma groups. This is consistent with other studies that hydrophilic surface modifications such as HSM coating38 or PEG-grafting1546 could significantly reduce LECs adhesion and postoperative foreign-body reaction of hydrophobic IOL.…”

“…5a,b). Similar to the inflammatory responses in human patients after IOL implantation438, both ACF and ACC scores peaked 1 day postoperatively, and then decreased to the baseline after 4 weeks. Rabbit eyes with implantation of IOL-P ( MPC-MAA ) had significantly lower ACF and ACC scores 1 day, 4 days, and 1 week after surgery.…”

The intraocular lens as a drug delivery device for an epidermal growth factor–Receptor inhibitor for prophylaxis of posterior capsule opacification

“…This method has resulted in sustained release and long‐term effects on endophthalmitis and intraocular inflammation after cataract surgery (Krall et al. ). Furthermore, pharmacological IOL modification has been suggested as a suitable means of fighting PCO (Behar‐Cohen et al.…”

Current Developments in Monofocal Intraocular Lens Technology

“…Heparin coated IOL can reduce the postoperative intraocular inflammation [8] . The use of this IOL should be considered in high risk patient group especially pediatric population.…”

“…Heparin coating is a surface modification that enhances the uveal biocompatibility of IOL. Fewer aqueous flare are seen after implantation of heparin coated IOL [8] . Although heparin coated IOL increases the risk of PCO, this increase is not found statistically significant [9] .…”