The macrophage activation marker s<scp>CD</scp>163 is associated with changes in <scp>NAFLD</scp> and metabolic profile during lifestyle intervention in obese children

Kazankov, Konstantin; Møller, Holger Jon; Lange, Aksel; Birkebæk, Niels H; Holland-Fischer, Peter; Solvig, Jan; Hørlyck, Arne; Kristensen, Kurt; Rittig, Søren; Handberg, Aase; Vilstrup, Hendrik; Grønbæk, Henning

doi:10.1111/ijpo.252

Cited by 52 publications

(46 citation statements)

References 30 publications

(36 reference statements)

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“…sCD163 concentration is highly increased in various liver diseases characterized by inflammation and fibrosis, e.g. viral hepatitis (39) and cirrhosis (40), and, in a recent study in obese children, sCD163 was increased in children with increased ALAT, steatosis, and high pediatric NAFLD fibrosis index (41). Liver fat content is closely associated with obesity, but is greater in T2DM patients compared with BMI-matched non-diabetic subjects (27).…”

Section: Discussionmentioning

confidence: 96%

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Sørensen¹,

Parkner²,

Søndergaard³

et al. 2015

Endocrine Connections

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Monocyte/macrophage-specific soluble CD163 (sCD163) concentration is associated with insulin resistance and increases with deteriorating glycemic control independently of BMI. This led to the proposal of the hypothesis that obesity-associated white adipose tissue inflammation varies between individuals. The objective was to examine the effect of male overweight/obesity and type 2 diabetes mellitus (T2DM) on associations between adiposity parameters and sCD163. A total of 23 overweight/obese non-diabetic men, 16 overweight/obese men with T2DM, and a control group of 20 normal-weight healthy men were included. Body composition and regional body fat distribution were determined by whole-body dual X-ray absorptiometry scan and abdominal computed tomography (CT) scan. Serum sCD163 concentrations were determined by ELISA. Associations between adiposity parameters and sCD163 were investigated using multiple linear regression analysis. In the normal-weight healthy men, there was no significant association between adiposity parameters and sCD163, whereas in the overweight/obese non-diabetic men, measures of general and regional adiposity were positively associated with sCD163. In the overweight/obese men with T2DM, only visceral adipose tissue (VAT) and the ratio of VAT to abdominal subcutaneous adipose tissue (SAT), a measure of relative body fat distribution between VAT and SAT depots, were positively associated with sCD163. In a multivariate analysis, including VAT, upper-body SAT, and lower-body fat, adjusted for BMI and age, VAT remained a significant predictor of sCD163 in the overweight/obese T2DM men, but not in the overweight/obese non-diabetic men. Our results indicate that VAT inflammation is exaggerated in men with T2DM, and that propensity to store excess body fat viscerally is particularly detrimental in men with T2DM.

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Section: Discussionmentioning

confidence: 96%

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Sørensen¹,

Parkner²,

Søndergaard³

et al. 2015

Endocrine Connections

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“…However, upon macrophage activation, CD163 is shed as its soluble form (sCD163) that can be measured in the circulation and serve as a biochemical marker of macrophage M1 activation [138]. sCD163 was associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children and in morbidly obese patients after bariatric surgery [139]. sCD163 increases in parallel with the severity of NAFLD and is reduced by lifestyle or surgical intervention, thus suggesting that macrophage M1 activation is reversible [139].…”

Section: Liver Tissue Inflammationmentioning

confidence: 99%

“…sCD163 was associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children and in morbidly obese patients after bariatric surgery [139]. sCD163 increases in parallel with the severity of NAFLD and is reduced by lifestyle or surgical intervention, thus suggesting that macrophage M1 activation is reversible [139]. In this context, M2 KC polarization might protect against fatty liver disease morbidly injury [108].…”

Section: Liver Tissue Inflammationmentioning

confidence: 99%

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

Alisi

Carpino

Oliveira

et al. 2017

Mediators of Inflammation

145

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The obese phenotype is characterized by a state of chronic low-grade systemic inflammation that contributes to the development of comorbidities, including nonalcoholic fatty liver disease (NAFLD). In fact, NAFLD is often associated with adipocyte enlargement and consequent macrophage recruitment and inflammation. Macrophage polarization is often associated with the proinflammatory state in adipose tissue. In particular, an increase of M1 macrophages number or of M1/M2 ratio triggers the production and secretion of various proinflammatory signals (i.e., adipocytokines). Next, these inflammatory factors may reach the liver leading to local M1/M2 macrophage polarization and consequent onset of the histological damage characteristic of NAFLD. Thus, the role of macrophage polarization and inflammatory signals appears to be central for pathogenesis and progression of NAFLD, even if the heterogeneity of macrophages and molecular mechanisms that govern their phenotype switch remain incompletely understood. In this review, we discuss the role of adipose and liver tissue macrophage-mediated inflammation in experimental and human NAFLD. This focus is relevant because it may help researchers that approach clinical and experimental studies on this disease advancing the knowledge of mechanisms that could be targeted in order to revert NAFLD-related fibrosis.

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“…This study population was previously described in details. [28][29][30] Of the original 117 participants, baseline plasma for sCD36 measurement was available in 113 participants.…”

Section: Study Population and Clinical Examinationsmentioning

confidence: 99%

“…29,30 Total liver scores were determined by adding up the three scores. Fatty liver was defined as an echogenicity score of 1 or above.…”

Section: Insulin Resistancementioning

confidence: 99%

Reduced sCD36 following weight loss corresponds to improved insulin sensitivity, dyslipidemia and liver fat in obese children

et al. 2016

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The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children

Cited by 52 publications

References 30 publications

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

Reduced sCD36 following weight loss corresponds to improved insulin sensitivity, dyslipidemia and liver fat in obese children

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