Meta‐analysis shows that infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications

Abstract

Infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications such as brain damage and, or, neurodevelopmental delay.

Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis

“…Despite recent advances in neonatal intensive care, sepsis remains an important cause of morbidity and mortality, particularly among preterm infants [1,2] . Neonatal sepsis causes poor neurodevelopmental outcomes in preterm infants [3][4][5][6][7] .…”

“…Neonatal sepsis is a major cause of morbidity and mortality in neonatal intensive care units [1] and is prevalent in premature infants [2] . Many clinical studies have…”

Gut bacteria and late-onset neonatal bloodstream infections in preterm infants

“…Infants who have had culture-proven late-onset neonatal bloodstream infections have higher mortality than those who have not had these infections [1,6]. Late-onset neonatal bloodstream infections in very low birth weight infants bestow independent risks to long-term child development, in addition to the wellrecognized risks bestowed by brain injury, bronchopulmonary dysplasia, and retinopathy of prematurity [2].…”

Elevated circulating ghrelin, but not peptide YY(3-36) levels, in term neonates with infection

“…Infants who have suffered neonatal sepsis face an increased risk for brain damage and neurodevelopmental delays [2,3], whereas, experimental data have shown that inflammation/infection early in life may alter the developmental trajectory of the immune system and the brain [4,5]. Early diagnosis and management of neonatal infection improves prognosis; thus, the identification of new or complementary biomarkers of neonatal infection or sepsis is of potential importance [6].…”