Influence of threatened miscarriage on pregnancy and early postpartum period: a case–control report

Özdemirci, Şafak; Karahanoğlu, Ertuğrul; Esinler, Deniz; Gelişen, Orhan; Kayıkçıoğlu, Fulya

doi:10.3109/14767058.2014.947577

Cited by 10 publications

(12 citation statements)

References 12 publications

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“…Although we detected abruptio placentae more frequently in the group of patients with the risk of miscarriage than in the control group (OR 95% CI 2.99), no significant difference was detected. Our abruptio placenta results are like many previous studies [9,11,18,23,24]. However, there are also publications linking abruptio placentae with the risk of miscarriage [19].…”

Section: Discussionsupporting

confidence: 88%

“…Weiss et al have shown that there may be an increase in the incidence of preeclampsia, which is a serious complication, in pregnancies with the risk of miscarriage [11]. Conversely, in our study, and in many instances in the literature there was no relationship between preeclampsia and the risk of miscarriage [7,9,19,23]. In our study, placenta previa was more frequent in the patients with the risk of miscarriage in the first trimester than in the control group.…”

Section: Discussioncontrasting

confidence: 68%

“…The mean gestational age and mean birth weight in pregnancies with the risk of miscarriage in the first trimester were lower than those in pregnancies without the risk of miscarriage. Since previous publications show that there is a relationship between the risk of miscarriage and preterm delivery, it would not be wrong to expect that the average gestational week and average birth weight would be lower than pregnancies without the risk of miscarriage [9,11,15,[18][19][20]. There was no significant difference between the groups in terms of fetal sex and BMI (Tab.…”

Section: Discussionmentioning

confidence: 85%

“…Pregnancy complications such as preeclampsia, intrauterine growth retardation (IUGR), low birth weight (LBW) and abruptio placentae are associated with placental problems; hence, the risk of these complications increases in the later weeks of pregnancies with the risk of miscarriage [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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The effects of threatened abortions on pregnancy outcomes

et al. 2019

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Objectives: The effects of first trimester threatened abortions on prenatal and postnatal pregnancy outcomes. Material and methods: Data from 24.835 pregnant women were retrospectively analysed. The pregnant women were divided into two groups according to whether they had a first trimester threatened abortion or not. The demographic data and prenatal, postnatal and labour outcomes were compared for the two groups. Those cases with miscarriages during their follow-up, pregnant women with systemic diseases, multiple pregnancies and patients who were diagnosed with cervical erosion and cervical polypoid formation during vaginal bleeding examinations were all excluded. Results: The age (p < 0.001), ART pregnancy rate (p = 0.03) and nulliparity rate (p = 0.013) in those with the risk of miscarriage were statistically significantly higher than those without the risk. The gestational weeks (p < 0.001) and birth weights (p < 0.001) were significantly lower for the miscarriage group than in the control group. Hyperemesis gravidarum (p < 0.001), gestational diabetes mellitus (GDM) (p < 0.001) and placenta previa (p = 0.018) rates were statistically significantly and more frequent in the pregnancies with the threatened abortion group than in the control group. The rates of caesarean delivery were statistically significantly higher in the threatened abortion group (p < 0.001). Conclusions: Threatened abortion between 6-and 14-weeks gestational age is a complication that may cause anxiety in the early weeks of pregnancy. But the treatment, follow-up and cause of threatened abortion all remain unclear.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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The effects of threatened abortions on pregnancy outcomes

et al. 2019

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“…Поліморфізм гена рецептора прогестерону визначає різну активність рецепторної функції. У свою чергу, різна активність рецептора сприяє зміні чутливості до ендогенного та екзогенного прогестерону [5].…”

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Threatened abortion treatment efficacy depending on progesterone receptor gene polymorphism

Gnatko¹,

Kryvopustov²

2017

Buk. Med. Herald

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Національний медичний університет імені О.О. Богомольця, м. Київ Резюме. Проведено аналіз ефективності прогестеронової терапії загрозливого аборту в 67 жінок репродуктивного віку в термінах гестації 8-16 тижнів із урахуванням алельного поліморфізму гена рецептора прогестерону (SNP PGR) rs590688 та rs500760. З'ясовано, що на перебіг захворювання статистично значущий вплив має SNP PGR rs590688. Більш тяжкий клінічний перебіг та низька відповідь на лікування натуральним мікронізованим прогестероном статистично значущо асоціювались з наявністю гомозиготи за диким алелем СС за SNP PGR rs590688. SNP PGR rs500760 не показав статистично значущого впливу на клінічний перебіг загрозливого аборту і на ефективність лікування натуральним мікронізованим прогестероном.Ключові слова: алельний поліморфізм, ген рецептора прогестерону, загрозливий аборт, клінічний перебіг, ефективність прогестеронової терапії.

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Sex Hormone Metabolism and Threatened Abortion

Chen

Wei

et al. 2017

Med Sci Monit

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BackgroundThe aim of this study was to evaluate changes in sex hormone metabolism in patients with threatened miscarriage.Material/MethodWe recruited 73 women in early pregnancy (6–8 weeks of gestation) and divided them into the following 2 groups based on whether they had vaginal bleeding: group A (n=34), the threatened abortion group; and group B (n=39), the normal pregnancy group. Human chorionic gonadotrophin (hCG), estradiol (E2), progesterone (P4), and testosterone (T) serum levels were tested and sex hormone metabolites in the urine were detected using gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS). As the control, data for sex hormones and their metabolites were obtained in normal women of childbearing age without pregnancy (group C: n=23).ResultsE2 and T serum levels were lower in women with threatened miscarriage (group A). Estrone (E1), E2, estriol (E3), 16α-hydroxyestrone (16α-OHE1), 4-methoxyestrone (4-MeOE1), 2-hydroxyestradiol (2-OHE2), and 4-methoxyestradiol (4-MeOE2) levels were significantly lower in group A (P=0.001, 0.003, 0.009, 0.001, 0.012, 0.032, and 0.047, respectively.). Urine levels of dehydroepiandrosterone (DHEA), androstenedione (A2), and the metabolite of (A2) were also significantly lower in group A (P=0.007, 0.009, and 0.011, respectively). The 2-OHE1/E1, 4-OHE1/E1, 2-MeOE1/E1, and 2-MeOE2/E2 ratios were lower in group B, whereas the 2-OHE2/E2, 4-OHE2/E2, and 4-MeOE2/E2 ratios were dramatically lower in all pregnant women (groups A and B) than in group C.ConclusionsDeficiency in DHEA and abnormal levels of sex hormone metabolites may cause a reduction in the activity of estrogens in women with threatened abortion. These alterations may result in bleeding during the first trimester of pregnancy.

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Influence of threatened miscarriage on pregnancy and early postpartum period: a case–control report

Cited by 10 publications

References 12 publications

The effects of threatened abortions on pregnancy outcomes

The effects of threatened abortions on pregnancy outcomes

Threatened abortion treatment efficacy depending on progesterone receptor gene polymorphism

Sex Hormone Metabolism and Threatened Abortion

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