Quantification of myocardial blood flow using 201Tl SPECT and population-based input function

Koshino, Kazuhiro; Fukushima, Kazuhito; Fukumoto, Masaji; Hori, Yuki; Moriguchi, T.; Zeniya, Tsutomu; Nishimura, Yoshihiro; Kiso, Keisuke; Iida, Hidehiro

doi:10.1007/s12149-014-0888-8

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Several investigators have already validated the SIF approach for human use. 10 , 11 , 12 , 13 Furthermore, a study reported the application of the SIF approach to CMRGlc measurement in small animals with one or two arterial blood samples for scaling the SIF, thereby allowing for accurate estimation of the AIF in each subject's level. 14 It is thus indicated that the SIF technique with a few arterial blood samples may serve as a simplified quantification method of CMRGlc in small animals.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using ¹⁸F-FDG PET and Standard Input Function

Hori

Ihara

Teramoto

et al. 2015

J Cereb Blood Flow Metab

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Measurement of arterial input function (AIF) for quantitative positron emission tomography (PET) studies is technically challenging. The present study aimed to develop a method based on a standard arterial input function (SIF) to estimate input function without blood sampling. We performed 18F-fluolodeoxyglucose studies accompanied by continuous blood sampling for measurement of AIF in 11 rats. Standard arterial input function was calculated by averaging AIFs from eight anesthetized rats, after normalization with body mass (BM) and injected dose (ID). Then, the individual input function was estimated using two types of SIF: (1) SIF calibrated by the individual's BM and ID (estimated individual input function, EIFNS) and (2) SIF calibrated by a single blood sampling as proposed previously (EIF1S). No significant differences in area under the curve (AUC) or cerebral metabolic rate for glucose (CMRGlc) were found across the AIF-, EIFNS-, and EIF1S-based methods using repeated measures analysis of variance. In the correlation analysis, AUC or CMRGlc derived from EIFNS was highly correlated with those derived from AIF and EIF1S. Preliminary comparison between AIF and EIFNS in three awake rats supported an idea that the method might be applicable to behaving animals. The present study suggests that EIFNS method might serve as a noninvasive substitute for individual AIF measurement.

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Section: Introductionmentioning

confidence: 99%

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using ¹⁸F-FDG PET and Standard Input Function

Hori

Ihara

Teramoto

et al. 2015

J Cereb Blood Flow Metab

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“…Unlike a dedicated cardiac SPECT camera with solid-state detectors, the conventional two-headed SPECT camera is readily available and widely used in the nuclear medicine community; hence it is possible to reproduce the method on clinically installed systems. 23-25 …”

Section: Discussionmentioning

confidence: 99%

Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation

Shrestha

Sciammarella

Alhassen

et al. 2017

Journal of Nuclear Cardiology

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Background The objective of this study was to measure myocardial blood flow (MBF) in humans using 99mTc-tetrofosmin and dynamic single photon emission computed tomography (SPECT). Methods Dynamic SPECT using 99mTc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for 99mTc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for 99mTc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve K1=Ftrue(1−Aexptrue(−BFtrue)true) for K1 values estimated with 99mTc-tefrofosmin using SPECT and MBF values estimated with 13N-NH3 using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with 13N-NH3 PET. The flow dependent permeability surface-area product (PS) for 99mTc-tefrofosmin was also estimated. Results The estimated flow extraction parameters for 99mTc-tefrofosmin was found to be A=0.91±0.11, B=0.34±0.20 (R2 = 0.49). The range of MBF in LAD, RCA, and LCX was 0.44 ml/min/g to 3.81 ml/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (p < 0.001). However, the corresponding CFR correlation was moderate r = 0.39 yet statistically significant (p = 0.037). The PS for 99mTc-tefrofosmin was (0.091 ± 0.10) * MBF = (0.32 ± 0.16). Conclusions Dynamic cardiac SPECT using 99mTc-tetrofosmin and a clinical two-headed SPECT/CT scanner can be a useful tool for estimation of MBF.

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“…Global MBF was derived from the corresponding K1 values using the Renkin-Crone equation for 201 Tl [20,21]. MBF value was obtained from the K1 value and corrected for the first-pass extraction fraction (EF) and hematocrit (Hct) using the equation MBF = K1*/EF, where EF = 1-0.57*e À1.02/MBF and K1* = K1/(1-Hct) [22,23]. MPR was then computed as a ratio of the stress to rest MBF values (MPR = stress MBF/rest MBF).…”

Section: Spect Images and Quantitative Analysismentioning

confidence: 99%

Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging

Shiraishi

Tsuda

Sakamoto

et al. 2020

Journal of Cardiology

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Radionuclide myocardial perfusion imaging (MPI) allows the visualization of radiopharmaceuticals distributed throughout the myocardium in proportion to the myocardial blood flow (MBF) and this facilitates the determination of the relative blood flow in various regions of the heart. Myocardial perfusion single-photon emission computed tomography (MPS) is a widely used noninvasive technique to evaluate ischemia and to stratify risk factors in patients with known or suspected coronary artery disease (CAD) [1-3].However, crucial limitations with respect to visual or semiquantitative assessment of regional myocardial perfusion defects can result in the underestimation or misdiagnosis of "balanced" ischemia. In other words, in patients with a balanced multi-vessel CAD or microcirculatory disorders a global reduction in myocardial perfusion can be completely overlooked when assessment is based solely on the relative radiotracer uptake.

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Quantification of myocardial blood flow using 201Tl SPECT and population-based input function

Abstract: This study demonstrated that the proposed technique based on a STD-IF and one-point blood sample provided hemodynamically reasonable global MBF values and the regional MBF values comparable to those with IND-IFs.

Cited by 7 publications

References 20 publications

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using ¹⁸F-FDG PET and Standard Input Function

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using ¹⁸F-FDG PET and Standard Input Function

Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation

Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging

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Quantification of myocardial blood flow using 201Tl SPECT and population-based input function

Abstract: This study demonstrated that the proposed technique based on a STD-IF and one-point blood sample provided hemodynamically reasonable global MBF values and the regional MBF values comparable to those with IND-IFs.

Cited by 7 publications

References 20 publications

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using 18F-FDG PET and Standard Input Function

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using 18F-FDG PET and Standard Input Function

Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation

Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging

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Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using ¹⁸F-FDG PET and Standard Input Function

Noninvasive Quantification of Cerebral Metabolic Rate for Glucose in Rats Using ¹⁸F-FDG PET and Standard Input Function