Improving lipid control following myocardial infarction

Ankam, Jyoti; Feldman, David; Blaha, Michael J.; Martin, Seth S.

doi:10.1097/hco.0000000000000093

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…El análisis multivariado halló que las variables tener un antecedente personal de IAM se asoció con una elevada probabilidad de control, dato que concuerda con estudios en los cuales los pacientes de mayor riesgo cardiovascular eran seguidos y tratados más agresivamente con estatinas de alta potencia como prevención secundaria (8,13,16,17). Además, la asociación con mejor control en una determinada ciudad, en este caso Manizales, es un hallazgo común en estudios farmacoepidemiológicos en los cuales influyen las diferencias en formación médica, pautas de tratamiento y calidad de los servicios de salud entre diferentes lugares (8).…”

Section: Discussionunclassified

Tratamiento hipolipemiante y su efectividad en pacientes de cuatro ciudades colombianas, 2012-2013.

et al. 2017

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Introducción. La prevalencia de enfermedad cardiovascular ha aumentado, la hipercolesterolemia se ha asociado como factor de riesgo y se desconoce en algunas poblaciones cuántos pacientes logran el control metabólico. Objetivo: Determinar la efectividad del tratamiento hipolipemiante en pacientes afiliados al Sistema de Salud Colombiano. Métodos. Estudio de corte transversal para determinar la efectividad del tratamiento hipolipemiante, en una muestra aleatoria de 211 pacientes adultos tratados con estatinas, en cuatro ciudades colombianas entre 2012 y 2013. Se obtuvieron variables sociodemográficas, antropométricas, cardiovasculares, farmacológicas y paraclínicas (Colesterol Total (CT), LDL, HDL, triglicéridos). Resultados. Se encontró predominio femenino (56,4%), promedio de edad 64±12 años, tratados en monoterapia con atorvastatina 63,9% y lovastatina 35,0%. El 43,4% de los casos de alto riesgo alcanzó la meta de C-LDL. El promedio de Colesterol-LDL inicial en pacientes con atorvastatina fue de 103,7±48,2 mg/dL y final fue 81,9±31,2 mg/dL con una reducción promedio de 21,0% de los valores, esta diferencia fue estadísticamente significativa (p

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Section: Discussionunclassified

Tratamiento hipolipemiante y su efectividad en pacientes de cuatro ciudades colombianas, 2012-2013.

et al. 2017

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“…The finding that diabetesassociated risk of subsequent MI or stroke did not diminish with increasing duration of diabetes compared to the peak in corresponding event risk 15 years after the initial MI or stroke is of interest. This may reflect differences in modulation of vascular pathophysiology by diabetes (35) or possibly greater success of medical therapy for secondary prevention of MI and stroke (36). Improvements in management of risk factors and overall medical care may be contributing to a narrowing in the mortality gap be- tween diabetic and nondiabetic individuals (37,38), yet extended duration of diabetes remains a contributor to macrovascular events in the older demographic where its prevalence is highest.…”

Section: Discussionmentioning

confidence: 99%

Diabetes, Myocardial Infarction and Stroke Are Distinct and Duration-Dependent Predictors of Subsequent Cardiovascular Events and All-Cause Mortality in Older Men

Yeap

McCaul

Flicker

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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In older men, increasing duration of diabetes predicts stable increases in all-cause and MI-related mortality and a progressively higher risk of stroke deaths. Prior MI was associated with increased risk of subsequent MI, and prior stroke with subsequent stroke, particularly in the 10-20 years following the first event. Diabetes is a duration-dependent risk factor for cardiovascular events which influences outcomes differently from prior vascular disease.

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“…10,11 As Nepal is a resource poor country, if there is a continuous increase in disease burden by non-communicable disease such as CAD, Nepalese people cannot afford the costly curative services. 12 As in highincome countries, the major risk factors in the Nepalese population include tobacco use, alcohol consumption, unhealthy diet and physical inactivity, 13,14 which were recognized based on a prevalence study. Moreover, although it has policy on smoking reduction such as banning smoking in public places and writing the risk of smoking on the cover of a cigarette box, the obvious risk of CAD has still not been documented.…”

Section: Introductionmentioning

confidence: 99%

Association of smoking with coronary artery disease in Nepalese populations: a case control study

Basnet

Mallah

et al. 2019

Toxicology Research

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There are well-known traditional risk factors for coronary artery disease (CAD). Among them, smoking is one of the most prominent and modifiable risk factors. This study aims to determine the magnitude of smoking as a risk factor for CAD in the Nepalese population. A hospital-based age- and sex-matched case–control study was carried out with a total of 612 respondents. Bivariate analysis showed that the risk of developing CAD in ex-smokers and current smokers was higher (odds ratio (OR): 1.81 (confidence interval (CI): 1.21–2.7) and OR: 5.2 (CI: 3.4–7.97)), with p-values less than 0.004 and <0.00001, respectively, compared to the risk in never smokers. From stratified socio-demographic, cardio-metabolic, behavioural and psychosocial risk factor analysis, smoking was found to be associated with CAD in almost all subgroups. In the subsequent multivariate analysis, adjustment for socio-demographic, cardio-metabolic and psychosocial risk factors showed a steady increase in risk. However, further adjustment for behavioural risk factors (alcohol use and physical activity) showed that the risk was attenuated by 59% in current smokers. After adjusting for the covariates, current smokers and ex-smokers had an increased risk of CAD (OR: 6.64, 95% CI: 3.64–12.12, p < 0.00001; OR: 1.89, 95% CI: 1.08–3.31, p < 0.012, respectively) compared with non-smokers. In conclusion, smoking was found to increase the risk of CAD in the Nepalese population.

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Improving lipid control following myocardial infarction

Abstract: Optimizing lipid control could further enhance clinical outcomes after myocardial infarction.

Cited by 8 publications

References 46 publications

Tratamiento hipolipemiante y su efectividad en pacientes de cuatro ciudades colombianas, 2012-2013.

Tratamiento hipolipemiante y su efectividad en pacientes de cuatro ciudades colombianas, 2012-2013.

Diabetes, Myocardial Infarction and Stroke Are Distinct and Duration-Dependent Predictors of Subsequent Cardiovascular Events and All-Cause Mortality in Older Men

Association of smoking with coronary artery disease in Nepalese populations: a case control study

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