Dimeric guaianolides from Artemisia absinthium

Turak, Ablajan; Shi, She‐Po; Jiang, Yong; Tu, Peng‐Fei

doi:10.1016/j.phytochem.2014.06.016

Cited by 40 publications

(17 citation statements)

References 17 publications

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“…Figura 5. Médias de massa seca da parte aérea e massa seca da raiz das plantas de Artemisia absinthium L. de acordo com as posições no perfil hidropônico *Massa seca da parte aérea ** Massa seca da raiz Fonte: Elaborada pelos autores (2017).…”

Section: Resultsunclassified

“…A parte aérea do absinto pode ser utilizada para preparações gástricas fitoterápicas, suplementos alimentares e bebidas alcoólicas (TURAK et al, 2014). Os compostos do óleo essencial da espécie possuem variadas propriedades biológicas, incluindo antimicrobiana, acaricida, inseticida, anti-helmínticos, antisséptico e antiespasmódico (RIAHI et al, 2015).…”

Section: Introductionunclassified

“…Concentração de macronutrientes (N, P, K, Ca, Mg e S) nas folhas de Artemisia absinthium L. sob a concentração de solução nutritiva proposta porFurlani et al (1999).Fonte: Elaborada pelos autores(2017).…”

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Cultivo de Artemisia absinthium L. sob concentrações de solução nutritiva em hidroponia

Luz

Oliveira

Aguilar

et al. 2018

R. Agrogeoambiental

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Losna ou absinto (Artemisa absinthium L.) é uma espécie utilizada desde a antiguidade devido a seu princípio ativo medicinal, com destaque no cenário atual por sua capacidade de fornecer substâncias úteis à indústria. Estudos sobre a produção de plantas medicinais em hidroponia podem encontrar alternativas viáveis para otimizar a produção, especialmente por fornecerem dados sobre o crescimento e produção. Neste contexto, objetivou-se avaliar o desenvolvimento do absinto sob concentrações de solução nutritiva e posição das plantas no perfil hidropônico, em sistema hidropônico NFT. O experimento foi conduzido entre os meses de abril e agosto de 2009 em delineamento de blocos ao acaso com cinco repetições, em esquema fatorial 4 x 3. Foram avaliadas altura, massa fresca e seca da parte aérea e de raízes. As plantas tiveram seu crescimento inicial em espuma fenólica e foram irrigadas com solução nutritiva diluída a 50 %. Após transplantadas para as bancadas de desenvolvimento, foram submetidas aos tratamentos: concentrações de solução nutritiva (50, 75, 100 e 125 %) e posições das plantas nos perfis hidropônicos (inicial, intermediária e final). A solução nutritiva a 50 % foi considerada a melhor opção de cultivo para absinto, uma vez que concentrações maiores não refletem em desenvolvimento significativo. Portanto, a redução pode ser utilizada sem comprometer a produção de biomassa, com economia de recursos naturais e financeiro.

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Section: Resultsunclassified

Section: Introductionunclassified

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Cultivo de Artemisia absinthium L. sob concentrações de solução nutritiva em hidroponia

Luz

Oliveira

Aguilar

et al. 2018

R. Agrogeoambiental

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“…Artemisia absinthium (Compositae), commonly known as wormwood, is widely distributed all over the world and it is described in different pharmacopoeias, with leaves and stems being used for medicinal purposes. This botanical drug is usually standardised based on its content in the dimeric guaianolides absinthins [ 68 ], being considered as a high-quality wormwood when it contains at least 0.2% of absinthin.…”

Section: Intestinal Anti-inflammatory Effects Of Botanical Drugs: mentioning

confidence: 99%

Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review

Algieri

Rodríguez-Nogales

Rodríguez-Cabezas

et al. 2015

Mediators of Inflammation

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Crohn's disease and ulcerative colitis are the two most common categories of inflammatory bowel disease (IBD), which are characterized by chronic inflammation of the intestine that comprises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their aetiology is not completely understood, nonfully efficient drugs have been developed and those that show effectiveness are not devoid of quite important adverse effects that impair their long-term use. Therefore, many patients try with some botanical drugs, which are safe and efficient after many years of use. However, it is necessary to properly evaluate these therapies to consider a new strategy for human IBD. In this report we have reviewed the main botanical drugs that have been assessed in clinical trials in human IBD and the mechanisms and the active compounds proposed for their beneficial effects.

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“…The chemical components of A. absinthium include sesquiterpene lactone, sesquiterpene lactone-pinene, β-thujone, α-thujone, sabinyl acetate, and β-thujone [9]. A. absinthium has pharmaceutical and medicinal effects such as antimicrobial [9], insecticidal [10], antiparasitic [11], antitumor [12], antipyretic [13], hepatoprotective [14,15], and antioxidant activities [16,17]. In the present study, A. absinthium ethanol extract (AAEE) and its subfractions including petroleum ether (AAEE-Pe) and ethyl acetate (AAEE-Ea) were prepared, and their antitumor effects on HCC were investigated both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

The Extracts of Artemisia absinthium L. Suppress the Growth of Hepatocellular Carcinoma Cells through Induction of Apoptosis via Endoplasmic Reticulum Stress and Mitochondrial-Dependent Pathway

Wei

Ziyayiding

et al. 2019

Molecules

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Artemisia absinthium L. has pharmaceutical and medicinal effects such as antimicrobial, antiparasitic, hepatoprotective, and antioxidant activities. Here, we prepared A. absinthium ethanol extract (AAEE) and its subfractions including petroleum ether (AAEE-Pe) and ethyl acetate (AAEE-Ea) and investigated their antitumor effect on human hepatoma BEL-7404 cells and mouse hepatoma H22 cells. The cell viability of hepatoma cells was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The apoptosis, cell cycle, mitochondrial membrane potential (Δψm), and reactive oxygen species (ROS) were analyzed by flow cytometry. The levels of proteins in the cell cycle and apoptotic pathways were detected by Western blot. AAEE, AAEE-Pe, and AAEE-Ea exhibited potent cytotoxicity for both BEL-7404 cells and H22 cells through the induction of cell apoptosis and cell cycle arrest. Moreover, AAEE, AAEE-Pe, and AAEE-Ea significantly reduced Δψm, increased the release of cytochrome c, and promoted the cleavage of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) in BEL-7404 and H22 cells. AAEE, AAEE-Pe, and AAEE-Ea significantly upregulated the levels of ROS and C/EBP-homologous protein (CHOP). Further, AAEE, AAEE-Pe, and AAEE-Ea significantly inhibited tumor growth in the H22 tumor mouse model and improved the survival of tumor mice without side effects. These results suggest that AAEE, AAEE-Pe, and AAEE-Ea inhibited the growth of hepatoma cells through induction of apoptosis, which might be mediated by the endoplasmic reticulum stress and mitochondrial-dependent pathway.

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Dimeric guaianolides from Artemisia absinthium

Cited by 40 publications

References 17 publications

Cultivo de Artemisia absinthium L. sob concentrações de solução nutritiva em hidroponia

Cultivo de Artemisia absinthium L. sob concentrações de solução nutritiva em hidroponia

Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review

The Extracts of Artemisia absinthium L. Suppress the Growth of Hepatocellular Carcinoma Cells through Induction of Apoptosis via Endoplasmic Reticulum Stress and Mitochondrial-Dependent Pathway

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