Hours lying down per day and mortality from all-causes and cardiovascular disease: the HUNT Study, Norway

Holtermann, Andreas; Mork, Paul Jarle; Nilsen, Tom Ivar Lund

doi:10.1007/s10654-014-9939-7

Cited by 15 publications

(12 citation statements)

References 18 publications

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“…[114][115][116][117][118][119][120][121] Most have used self-report measures, including time spent watching TV, sitting, lying down, or riding in a car. For example, the US National Institutes of Health-AARP Diet and Health Study 119 followed up 240 819 middle-aged adults for a mean of 8.5 years, classifying them according to time spent in TV viewing, sitting, and MVPA.…”

Section: All-cause and Cause-specific Mortalitymentioning

confidence: 99%

Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association

et al. 2016

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Epidemiological evidence is accumulating that indicates greater time spent in sedentary behavior is associated with all-cause and cardiovascular morbidity and mortality in adults such that some countries have disseminated broad guidelines that recommend minimizing sedentary behaviors. Research examining the possible deleterious consequences of excess sedentary behavior is rapidly evolving, with the epidemiologybased literature ahead of potential biological mechanisms that might explain the observed associations. This American Heart Association science advisory reviews the current evidence on sedentary behavior in terms of assessment methods, population prevalence, determinants, associations with cardiovascular disease incidence and mortality, potential underlying mechanisms, and interventions. Recommendations for future research on this emerging cardiovascular health topic are included. Further evidence is required to better inform public health interventions and future quantitative guidelines on sedentary behavior and cardiovascular health outcomes. E vidence is accumulating that sedentary behavior might be associated with increased cardiovascular-specific and overall mortality. Insufficient physical activity predicts premature cardiovascular disease (CVD) mortality and disease burden, such that the United States and other developed countries have issued physical activity guidelines, but these guidelines are specific to physical activity and do not include sedentary behavior.1 Sedentary behavior guidelines to reduce the risk of chronic diseases for adults have been developed in some countries, but they are broadly stated and nonquantitative. For example, Australia and the United Kingdom have public health guidelines stating that adults should minimize the amount of time spent being sedentary (sitting) for extended periods.2,3 Such broad public health guidelines for adults are likely appropriate, because evidence is still accumulating regarding the strength of the association, the evidence for causation (including understanding mechanisms), and the support for dose-response relationships that demonstrate sedentary behavior to be an independent risk factor for adverse health outcomes. Although at one time, excess sedentary behavior was considered to be at one end of the continuum of physical activity such that a person with no moderateto-vigorous physical activity (MVPA) was considered "sedentary," consensus is building that sedentary behavior is distinct from lack of MVPA. Even the word "sedentary," derived from the Latin "sedentarius" and defined as "sitting, remaining in one place," connotes a different set of behaviors than non-MVPA. 4 Thus, researchers studying MVPA, physical inactivity, and sedentary behavior are now viewing these behaviors as separate entities with their own unique determinants and health consequences. CLiniCAL STATEMEnTS And GUidELinESThis American Heart Association science advisory summarizes the existing evidence about sedentary behavior as a potential risk factor for CVD and...

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Section: All-cause and Cause-specific Mortalitymentioning

confidence: 99%

Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association

et al. 2016

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“…In main analysis, logistic regression model was used to estimate crude ORs with 95% CI for incident diabetes by categories of hours lying down using 8 hours/day as the reference. The adjusted ORs were obtained after adjustment for potential confounding factors including sex, age, BMI, smoking status, alcohol intake per month, family history of diabetes, chronic diseases, education, economic difficulties, total sitting time per day, leisure-time physical activity and type of work 10 17. Missing information of the covariates was included as a separate category in the analysis.…”

Section: Methodsmentioning

confidence: 99%

“…It may be used as an alternative marker for sedentary behaviour and pose an independent health risk 9. The detrimental effect of total time spent lying down on cardiovascular health has been highlighted in large prospective cohort studies 10 11. Higher mortality from cardiovascular diseases was observed among adults who reported prolonged hours lying down per day, even in physically active individuals 10.…”

Section: Introductionmentioning

confidence: 99%

“…The detrimental effect of total time spent lying down on cardiovascular health has been highlighted in large prospective cohort studies 10 11. Higher mortality from cardiovascular diseases was observed among adults who reported prolonged hours lying down per day, even in physically active individuals 10. Although small-scale experimental studies showed that prolonged bed rest was positively associated with muscle atrophy and insulin resistance,12–14 research on potential long-term effect of total hours lying down on diabetes risk at population level has been limited.…”

Section: Introductionmentioning

confidence: 99%

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Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study

et al. 2020

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ObjectiveWe aimed to examine relationship between hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults, and to assess if leisure-time physical activity and body mass index (BMI) modified this relationship.DesignA population-based prospective cohort study.SettingNord-Trøndelag, Norway.ParticipantsThe cohort included 17 058 diabetes-free adults, at an age of 20–55 years in 1995–1997, who were followed-up to 2006–2008.Primary outcome measuresIncident diabetes was defined by self-report of diabetes or non-fasting glucose levels greater than 11 mmol/L at the follow-up.MethodsMultivariable logistic regression models were used to obtain OR with 95% CI for risk of diabetes by the categories of hours lying down (≤7, 8 and ≥9 hours/day).Results362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the ORs associated with lying down ≥9 hours/day were 1.41 (95% CI 1.05 to 1.90) and 0.90 (95% CI 0.23 to 3.55), respectively, among the less active and highly active individuals (pinteraction=0.048). There was little evidence that the association differed by BMI status (pinteraction=0.62).ConclusionsProlonged hours lying down per day was associated with an increased risk of diabetes in young and middle-aged adults. The positive association appeared to be modified by physical activity but not by BMI.

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“…Blood flow stagnates during excessive sitting and bed rest leading to nitric oxide and BDNF deficiencies associated with a higher risk to coronary artery disease and mortality as well as increased risk to dementias. [1][2][3][4][5] American adults and children spend more than half their waking time sitting. This produces impaired insulin sensitivity, metabolic function and endothelial function, which are classic markers of arteriosclerotic heart disease (ASHD).…”

Section: Endothelial Functionmentioning

confidence: 99%

Is Awareness of Obesity and Type 2 Diabetes from Physical Inactivity in the Home and Workplace Well Recognized?

Sackner¹

2017

AOWMC

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Most recommendations from governmental agencies and the American Heart Association have focused on daily exercise regimens as a means to achieve good cardiovascular health and diminish risk of premature mortality. It has recently become apparent that physical inactivity marked by excessive sitting and/or lying down is a major risk for the worldwide growing epidemic of obesity and type 2 diabetes. This epidemic cannot be addressed by short term exercise if the rest of the day is spent in physical inactivity. Even when recognized, interventions to limit sitting time have failed to achieve major success because of the strong behavioral affinity to sit. In this paper, we propose that physical inactivity can be tolerated if an effortless, simulated jogging device that does not require multitasking is used at least two hours daily. Since watching television and/or a computer screen takes up several hours daily for most individuals, this recommendation is easily accomplished during such activities.

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Hours lying down per day and mortality from all-causes and cardiovascular disease: the HUNT Study, Norway

Cited by 15 publications

References 18 publications

Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association

Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association

Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study

Is Awareness of Obesity and Type 2 Diabetes from Physical Inactivity in the Home and Workplace Well Recognized?

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