Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study

Abstract

ObjectiveWe aimed to examine relationship between hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults, and to assess if leisure-time physical activity and body mass index (BMI) modified this relationship.DesignA population-based prospective cohort study.SettingNord-Trøndelag, Norway.ParticipantsThe cohort included 17 058 diabetes-free adults, at an age of 20–55 years in 1995–1997, who were followed-up to 2006–2008.Primary outcome measuresIncident diabetes was defined by self-report of diabetes or non-fasting glucose levels greater than 11 mmol/L at the follow-up.MethodsMultivariable logistic regression models were used to obtain OR with 95% CI for risk of diabetes by the categories of hours lying down (≤7, 8 and ≥9 hours/day).Results362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the ORs associated with lying down ≥9 hours/day were 1.41 (95% CI 1.05 to 1.90) and 0.90 (95% CI 0.23 to 3.55), respectively, among the less active and highly active individuals (pinteraction=0.048). There was little evidence that the association differed by BMI status (pinteraction=0.62).ConclusionsProlonged hours lying down per day was associated with an increased risk of diabetes in young and middle-aged adults. The positive association appeared to be modified by physical activity but not by BMI.

A Meta-Analysis of a Cohort Study on the Association between Sleep Duration and Type 2 Diabetes Mellitus

“…We have analyzed a total of 17 studies that involved 712818 participants [ 18 – 34 ]. The incidence of T2DM was 4.73% (10380/219678) in SSD ( t ≤ 6 h) and 4.39% (21652/493140) in NSD (6 h < t < 9 h).…”

“…Subgroup analyses were performed among male [ 25 , 26 , 29 , 33 ], female [ 25 , 26 , 29 , 33 , 34 ], and mixed male and female [ 18 – 24 , 27 , 28 , 30 – 32 ]. Meta-analysis showed that the incidence of T2DM in LSD was higher than that in NSD in the male subgroup (RR = 1.55, 95% CI: 1.08-2.21, P = 0.02).…”

“…After full-text screening, an additional 77 studies were excluded due to the following criteria: review article (n = 33), reported incomplete data (n = 23), commentary (n = 12), case report (n = 5), and duplicate report (n = 4). Finally, seventeen cohort studies were included in the present meta-analysis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Among them, fifteen were in English [18-25, 27, 28, 30-34] and two were in Chinese [26,29].…”

“…A total of 17 studies were selected for inclusion in this meta-analysis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], with 737002 people. Among them were five each from China [21,23,25,26,29], and the United States [19,28,30,31,34], and one study each from Norway [18], South Korea [20], Britain [22], Australia [24], Japan [27], Finland [32], and Sweden [33]. Four Journal of Diabetes Research studies' research subjects, those of Lou et al [ 25]., Gao et al [26], Li et al [29], and Mallon et al [33] were analyzed independently by gender.…”

“…Meta-analysis showed that the incidence of T2DM in SSD was higher than that in NSD in the mixed male and female subgroup (RR = 1:17, 95% CI: 1.10-1.25, P < 0:001) (Figure 3). Subgroup analyses were performed among the Asia [20,21,23,[25][26][27]29], America [19,28,30,31,34], Europe [18,22,32,33], and Oceania subgroups [24]. Meta-analysis showed that the incidence of T2DM in SSD was higher than that in NSD in the Asia subgroup (RR = 1:20, 95% CI: 1.07-1.35, P = 0:003).…”