Treatment with essential oil of Achyrocline satureioides in rats infected with Trypanosoma evansi: Relationship between protective effect and tissue damage

Baldissera, Matheus D.; Oliveira, Camila Belmonte; Rech, Virgínia Cielo; Rezer, João Felipe Peres; Sagrillo, Michele Rorato; Alves, Marta Palma; Silva, Ana P.T. da; Leal, Daniela Bitencourt Rosa; Boligon, Alexandra Augusti; Athayde, Margareth Linde; Silva, Aleksandro S. Da; Mendes, Ricardo E.; Monteiro, Sílvia González

doi:10.1016/j.prp.2014.06.008

Cited by 35 publications

(19 citation statements)

References 37 publications

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“…kidney without cellular alterations (Baldissera et al, 2014c). In animals treated with hydroalcoholic extract, A. satureioides did not change the levels of creatinine and urea (Barioni et al, 2013).…”

Section: Discussionmentioning

confidence: 88%

“…In nanocoated form, no increase in these parameters in relation to infected animals was observed; being possible to say that the encapsulated form was not able to cause toxicity. Rats infected and treated with A. satureioides (free and nanocapsules) showed moderate diffuse lymphoplasmacytic inflammatory infiltrate and necrosis, in the portal areas and sinusoids (Baldissera et al, 2014c), which would explain the increase in AST and ALT activity.…”

Section: Discussionmentioning

confidence: 98%

“…The suspension of nanocapsules containing A. satureioides was prepared according to the interfacial deposition of preformed polymer (Fessi et al, 1989), also descriptively detailed by Baldissera et al (2014c). All suspensions were prepared in triplicate and placed in amber glass bottles.…”

Section: Preparation and Characterization Of Nanocapsulesmentioning

confidence: 99%

“…Researchers found that A. satureioides essential oil and nanocapsules of A. satureioides, mainly the nanocapsules, minimized the effects of oxidative damage in rats infected by T. evansi, as well as trypanocidal action (Baldissera et al, 2014c). Nanotechnology has been used in order to improve its efficiency using reduced volumes, because this is possible by molecule manipulation to form new structural organization of their atoms (Martinez-Martin et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Preparation and Characterization Of Nanocapsulesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

Self Cite

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“…Alchornedine a new guanidine alkaloid from the leaves of Alchornea glandulosa was found effective against trypanosomiasis (Barrosa et al, 2014). In vitro trypanocidal activity of macela (Achyrocline satureioides) extracts against Trypanosoma evansi was also evaluated (Baldissera et al, 2014b).…”

Section: Alternative Approaches In Treatmentmentioning

confidence: 99%

Insight into Trypanosomiasis in Animals: Various Approaches for its Diagnosis, Treatment and Control: A Review

Jaiswal¹,

Sudan²,

Neha³

et al. 2015

Asian J. of Animal Sciences

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Trypanosomiasis is a haemoprotozoan disease entity caused by various members of Trypanosoma spp. affecting different species of domestic and wild animals like horses, mule, donkey, camel, cattle, buffaloes, sheep, goat, dogs, pig, elephant, deer, foxes, tiger and jackals with chief clinical signs of high intermittent fever, anaemia, loss of weight, edema of dependent parts, nervous symptoms, abortion and is responsible for major production losses. It can be transmitted through the biting flies wherein, the parasite may undergo biological or mechanical transmission. Various diagnostic methods from traditional to molecular are available for its diagnosis viz., microscopic examination, DNA detection by PCR, Card Agglutination Test and ELISA. The present review addresses important insights into trypanosomiasis, the etiological agent, advances and trends in its diagnosis, treatment aspects, prevention and control measures; which would help in limiting its prevalence in animals.

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Nerolidol-loaded nanospheres prevent behavioral impairment via ameliorating Na+, K+-ATPase and AChE activities as well as reducing oxidative stress in the brain of Trypanosoma evansi-infected mice

Baldissera

Souza

Grando

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

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The aim of this study was to investigate the effect of nerolidol-loaded nanospheres (N-NS) on the treatment of memory impairment caused by Trypanosoma evansi in mice, as well as oxidative stress, and Na, K-ATPase and acetylcholinesterase (AChE) activities in brain tissue. Animals were submitted to behavioral tasks (inhibitory avoidance task and open-field test) 4 days postinfection (PI). Reactive oxygen species (ROS) and thiobarbituric acid-reactive substance (TBARS) levels and catalase (CAT), superoxide dismutase (SOD), Na, K-ATPase and AChE activities were measured on the fifth-day PI. T. evansi-infected mice showed memory deficit, increased ROS and TBARS levels and SOD and AChE activities, and decreased CAT and Na, K-ATPase activities compared to uninfected mice. N-NS prevented memory impairment and oxidative stress parameters (except SOD activity), while free nerolidol (N-F) restored only CAT activity. Also, N-NS treatment was able to prevent alterations in Na, K-ATPase and AChE activities caused by T. evansi infection. A significantly negative correlation was observed between memory and ROS production (p < 0.001; r = -0.941), as well as between memory and AChE activity (p < 0.05; r = -0.774). On the contrary, a significantly positive correlation between memory and Na, K-ATPase activity was observed (p < 0.01; r = 0.844). In conclusion, N-NS was able to reverse memory impairment and to prevent increased ROS and TBARS levels due to amelioration of Na, K-ATPase and AChE activities and to activation of the antioxidant enzymes, respectively. These results suggest that N-NS treatment may be a useful strategy to treat memory dysfunction and oxidative stress caused by T. evansi infection.

show abstract

Treatment with essential oil of Achyrocline satureioides in rats infected with Trypanosoma evansi: Relationship between protective effect and tissue damage

Cited by 35 publications

References 37 publications

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Insight into Trypanosomiasis in Animals: Various Approaches for its Diagnosis, Treatment and Control: A Review

Nerolidol-loaded nanospheres prevent behavioral impairment via ameliorating Na+, K+-ATPase and AChE activities as well as reducing oxidative stress in the brain of Trypanosoma evansi-infected mice

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