Progress in pediatrics in 2013: choices in allergology, endocrinology, gastroenterology, hypertension, infectious diseases, neonatology, neurology, nutrition and respiratory tract illnesses

Caffarelli, Carlo; Santamaria, Francesca; Vottero, Alessandra; Dascola, Carlotta Povesi; Mirra, Virginia; Sperlì, Francesco; Bernasconi, Sergio

doi:10.1186/1824-7288-40-62

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…10 On the other hand, intestinal probiotics affect the amount of bilirubin in the enterohepatic circulation by reducing the degradation of bound bilirubin. 11 Meanwhile, they are able to stimulate intestinal peristalsis, which also benefits the elimination of bilirubin. It has previously been reported that oral administration of probiotics showed markedly better effects than those of routine blue light phototherapy.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of probiotics on neonatal jaundice

Liu¹,

Liu²,

Wang³

et al. 2015

Pak J Med Sci

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Objective:To evaluate the therapeutic effects of probiotics on neonatal jaundice and the safety.Methods:Sixty-eight neonates with jaundice were divided into a control group and a treatment group (n=34) randomly, and treated by blue light phototherapy and that in combination with probiotics. The serum bilirubin levels were detected before and 1, 4, 7 days after treatment. The time when therapy showed effects and jaundice faded, clinical outcomes as well as adverse reactions were recorded. The categorical data were expressed as (±s) and compared by t test. The numerical data were expressed as (case, %) and compared by χ² test. P<0.05 was considered statistically significant.Results:Serum bilirubin levels of the two groups were similar before treatment (P>0.05). The levels significantly decreased 1, 4 and 7 days after treatment (P<0.05), but there was no significant inter-group difference on the post-treatment 1st day (P>0.05). The treatment group underwent more significant decreases on the 4th and 7th days than the control group did (P=0.002, 0.001). In the treatment group, the therapy exerted effects on (1.0±0.5) d and jaundice faded on (3.8±1.7) d, which were (2.6±0.6) d and (5.3±2.1) d respectively in the control group (P=0.001, 0.002). The effective rate of the treatment group significantly exceeded that of the control group (P=0.002). There were no obvious adverse reactions in either group.Conclusions:Probiotics lowered the serum bilirubin levels of neonates with jaundice rapidly, safely and significantly, and accelerated jaundice fading as well. This method is worthy of application in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of probiotics on neonatal jaundice

Liu¹,

Liu²,

Wang³

et al. 2015

Pak J Med Sci

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A case report on atypical presentations of Dyke-Davidoff-Masson syndrome

Yang,

Hu,

Jiang

et al. 2024

Heliyon

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Melatonin: Possibilities for use in the treatment of asthma

Цветикова¹,

Budnevsky²,

Будневский³

et al. 2017

Terapevticheskii arkhiv

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Asthma is a serious health problem affecting all age groups. Melatonin or its agonists are commonly used to treat many diseases, but there are conflicting data on asthma therapy. This paper analyzes researches on the possible use of melatonin in the therapy of asthma. Melatonin is a potent antioxidant and a vasodilator, but in some experiments, it can act as a pro-oxidant and a vasoconstrictor, which may depend on the duration of use. It has been suggested that circadian rhythms should be corrected in asthmatics to optimize the desired effects of drugs and to reduce the severity of their adverse reactions. Disordered diurnal variations in the salivary levels of melatonin and cortisol are detectable in patients with asthma and may be implicated in its pathogenesis. In addition, the conflicting data on the effect of melatonin on the development of asthma are associated with an incomplete view of the factors influencing the level of melatonin. Thus, to study the effects of melatonin, it is necessary to take into account the greatest possible factors that may influence the level of melatonin and the course of asthma: a daily diet in terms of the use of caffeine, alcohol, sleep-wakefulness pattern, sleep quality proper, and drowsiness during the daytime, social burden, the level of anxiety and stress resistance, and to investigate the levels of endogenous melatonin or its derivatives, immune status, oxidative stress intensity, etc. Obviously, the use of melatonin in the therapy of asthma can be considered, by applying a personalized approach.

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Progress in pediatrics in 2013: choices in allergology, endocrinology, gastroenterology, hypertension, infectious diseases, neonatology, neurology, nutrition and respiratory tract illnesses

Cited by 4 publications

References 20 publications

Therapeutic effects of probiotics on neonatal jaundice

Therapeutic effects of probiotics on neonatal jaundice

A case report on atypical presentations of Dyke-Davidoff-Masson syndrome

Melatonin: Possibilities for use in the treatment of asthma

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