25 Year survival outcomes for squamous cell carcinomas of the head and neck: Population-based outcomes from a Canadian province

Tiwana, Manpreet S.; Wu, Jonn; Hay, John; Wong, Frances; Cheung, Winson Y.; Olson, Robert

doi:10.1016/j.oraloncology.2014.03.009

Cited by 72 publications

(68 citation statements)

References 19 publications

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“…This finding corroborates that of a different study, which described a higher prevalence of stage IV disease associated with a decrease in survival for all sites 13 . Furthermore, another study has reported poorer survival rates in metastatic disease, in which survival decreased from 41.5 to 32.5% during the follow-up period 27 .…”

Section: Discussionsupporting

confidence: 92%

“…In most countries, the 5-year survival rate for cancer of the tongue, mouth and oropharynx is approximately 50%, where cancer of the lip carries the best prognosis, which is higher than 90% 12,13 . Disease stage at diagnosis affects survival rates; for mouth, the survival rate at stage I is 70%, whereas for stage IV, it drops to 30% 13 .…”

mentioning

confidence: 99%

“…Disease stage at diagnosis affects survival rates; for mouth, the survival rate at stage I is 70%, whereas for stage IV, it drops to 30% 13 . One study reported that the 5-year survival rate in patients with cancer of the head and neck, mouth, oropharynx, hypopharynx and larynx was 24.1, 25.91, 19.2, 13.4 and 38%, respectively.…”

mentioning

confidence: 99%

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Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Schneider

Flores

Nickel

et al. 2014

Rev. bras. epidemiol.

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Introduction: Cancer of the lip, mouth and pharynx is a serious health problem. High incidence rates are found worldwide. In Brazil, the Southern and Southeastern regions have the highest incidences in the country. Objective: To describe 5 and 10-year survival rates in patients with cancer of the lip, mouth and pharynx at a referral center in Florianopolis, Santa Catarina, Brazil. Methods: Retrospective cohort study using data from patients diagnosed between January 1 st and December 31 st , 2001, with follow-up until December 31 st , 2011. Descriptive analysis was performed and survival was estimated by Kaplan-Meier method. Cox semiparametric model was used to estimate death risk. Results: Survival rates at 5 and 10 years were 33.3 and 26.9%, respectively. Advanced clinical stage in the diagnosis increased death risk by 2.88 and 2.51, respectively. Sex, ethnicity, level of education, previous diagnosis and treatment, as well as age, did not show significant association. Conclusion: Survival rate at 5 years was 33.3% and, at 10 years, was 26.9%. Advanced stage was an independent risk factor for death due to cancer of the lip, mouth and pharynx in both periods analyzed.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

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Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Schneider

Flores

Nickel

et al. 2014

Rev. bras. epidemiol.

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“…The higher rate of cancer-related death in older patients is consistent with findings from other population-based studies of head and neck cancer (61,62), as is the positive association between area-level deprivation and mortality (63)(64)(65). Moreover, the fact that our smoking results were adjusted for deprivation makes socioeconomic confounding an unlikely explanation for our findings in relation to smoking.…”

Section: Other Sociodemographic Prognostic Factorssupporting

confidence: 91%

Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study

Sharp

McDevitt

Carsin

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Some studies suggest smoking may result in poorer clinical outcomes in head and neck cancer, but the evidence is heterogeneous and some of it is poor quality. In a large, population-based, study we investigated: (i) whether smoking at diagnosis is an independent prognostic factor for cancer-specific survival in head and neck cancer; and (ii) whether the association varies by site and treatment.Methods: Head and neck cancers (ICD10 C01-C14, and C30-32) diagnosed from 1994 to 2009 were abstracted from the National Cancer Registry Ireland, and classified by smoking status at diagnosis. Follow-up was for 5 years or until December 31, 2010. Multivariate Cox proportional hazards models were used to compare cancerspecific death rates in current, ex-, and never smokers. Subgroup analyses by site and treatment were conducted.Results: In total, 5,652 head and neck cancers were included. At diagnosis, 24% were never smokers, 20% exsmokers, and 56% current smokers. Compared with never smokers, current smokers had a significantly raised death rate from cancer [multivariate HR, 1.36; 95% confidence interval (CI), 1.21-1.53]. The association was similar after restriction to squamous cell tumors. A significantly increased cancer-related death rate was seen for current smokers with oral cavity, pharyngeal, and laryngeal cancers. The association was stronger in surgically treated patients [HR, 1.49; 95% CI, 1.25-1.79; P(interaction) ¼ 0.01]. Neither radiotherapy nor chemotherapy modified the effect of smoking.Conclusions: Patients with head and neck cancer who smoke at diagnosis have a significantly increased cancer death rate.Impact: Greater efforts are needed to encourage and support smoking cessation in those at risk of, and diagnosed with, head and neck cancer. Cancer Epidemiol Biomarkers Prev; 23(11); 2579-90. Ó2014 AACR.

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“…Relatively higher survival rates were observed in younger patients (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) compared with older patients (65-74, 75+), particularly for sites including the stomach, lung, pancreas, B and CNS, blood (NHL) and cervix. Cancer of the oesophagus, female breast and bladder had higher survival in middle-aged groups (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)…”

Section: Resultsmentioning

confidence: 99%

Cancer survival in Qidong between 1972 and 2011: A population-based analysis

Chen

Zhu

Zhang

et al. 2017

Molecular and Clinical Oncology

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Abstract. Population-based cancer survival is an improved index for evaluating the overall efficiency of cancer health services in a given region. The current study analysed the observed survival and relative survival of leading cancer sites from a population-based cancer registry between 1972 and 2011 in Qidong, China. A total of 92,780 incident cases with cancer were registered and followed-up for survival status. The main sites of the cancer types, based on the rank order of incidence, were the liver, stomach, lung, colon and rectum, oesophagus, breast, pancreas, leukaemia, brain and central nervous system (B and CNS), bladder, blood [non-Hodgkin's lymphoma (NHL)] and cervix. For all malignancies combined, the 5-year observed survival was 13.18% and the relative survival was 15.80%. Females had higher observed survival and relative survival (19.32 and 22.71%, respectively) compared with males (9.63 and 11.68%, respectively). The cancer sites with the highest five-year relative survival rates were the female breast, bladder, cervix and colon and rectum; followed by NHL, stomach, B and CNS cancer and leukaemia. The poorest survival rates were cancers of oesophagus, lung, pancreas and liver. Higher survival rates were observed in younger patients compared with older patients. Cancers of the oesophagus, female breast and bladder were associated with higher survival in middle-aged groups. Improved survival rates in the most recent two 5-year calendar periods were identified for stomach, lung, colon and rectum, oesophagus, female breast and bladder cancer, as well as leukaemia and NHL. The observations of the current study provide the opportunity for evaluation of the survival outcomes of frequent cancer sites that reflects the changes and improvement in a rural area in China.

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25 Year survival outcomes for squamous cell carcinomas of the head and neck: Population-based outcomes from a Canadian province

Cited by 72 publications

References 19 publications

Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study

Cancer survival in Qidong between 1972 and 2011: A population-based analysis

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