25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study

García, Audry H; Erler, Nicole S.; Jaddoe, Vincent W. V.; Tiemeier, Henning; Hooven, Edith H. van den; Franco, Oscar H.; Rivadeneira, Fernando; Voortman, Trudy

doi:10.1016/s2213-8587(17)30064-5

Cited by 43 publications

(26 citation statements)

References 29 publications

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“…It was therefore unexpected to observe no association between 25(OH)D and HSPM prevalence in 6‐year‐old children. In line with our findings for enamel hypomineralization, however, we also recently observed no association of foetal vitamin D status with children's bone mass …”

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

“…We categorized 25(OH)D concentrations: ≥75 nmol/L (optimal), 50 to <75 nmol/L (sufficient), 25 to <50 nmol/L (deficient) and <25 nmol/L (severely deficient) on the basis of recommendations and cut-offs used in previous studies. 26,28 Measuring the 25(OH)D concentrations at three different time points and assessing hypomineralization at one time point resulted in four different subsets of the population; three subsets with a 25 (OH)D measurement at one point in time and dental data; and one subset with measurements at all three points in time and dental data. These subsets were highly comparable in terms of population characteristics (Table S2).…”

Section: (Oh)d Measurementmentioning

confidence: 99%

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Foetal, neonatal and child vitamin D status and enamel hypomineralization

Tas

Elfrink

Heijboer

et al. 2018

Comm Dent Oral Epid

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: (Oh)d Measurementmentioning

confidence: 99%

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Foetal, neonatal and child vitamin D status and enamel hypomineralization

Tas

Elfrink

Heijboer

et al. 2018

Comm Dent Oral Epid

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“…Vitamin D plays a central role in calcium and phosphate homeostasis, and severe vitamin D deficiency can result in rickets, osteomalacia and neonatal hypocalcaemia. There is increasing evidence of a link between maternal gestational 25(OH)D status and offspring bone mass (Harvey et al 2013(Harvey et al , 2014bJavaid et al 2006;Sayers & Tobias 2009;Mahon et al 2010;Viljakainen et al 2010;Zhu et al 2014), although not in all studies (Lawlor et al 2013;Garcia et al 2017), and that this association may be mediated partly through umbilical cord calcium concentrations (Javaid et al 2006). Expression of a particular active placental calcium transporter was positively associated with neonatal bone mass (Martin et al 2007), with regulation by 1,25 (OH) 2 -vitamin D implicated in experimental studies (Kip & Strehler 2004).…”

Section: Epigenetic Predictors Of Childhood Bone Healthmentioning

confidence: 99%

“…; Garcia et al . ), and that this association may be mediated partly through umbilical cord calcium concentrations (Javaid et al . ).…”

Section: Dna Methylation and Bone Development: Potential Roles In Latmentioning

confidence: 99%

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

Curtis

Suderman²,

Phillips

et al. 2018

Nutrition Bulletin

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The ALPHABET project, funded through the European Research Area Healthy Diet for a Healthy Life Biomarkers call, aims to expand the knowledge base regarding interactions between diet, epigenetics and offspring health, characterising biomarkers that may inform future health strategies. This review focuses on the UK Biotechnology and Biological Sciences Research Council (BBSRC)‐funded component in which the aim was to (1) generate and collate early‐life epigenetic data and (2) investigate early diet and epigenetic marks as predictors of later bone health. The project builds on a wealth of evidence implicating environmental factors, such as maternal diet and body composition, as influences on the long‐term health and development of the offspring, and that these relationships might be mediated at least in part through epigenetic signals. Experimental studies in animal models have demonstrated that manipulation of maternal diet during pregnancy leads to altered offspring epigenetic marking and phenotype. Human studies convincingly demonstrate associations between early environment and later health and disease for outcomes across musculoskeletal, respiratory, neurodevelopmental and cardiometabolic health. The priority now is to find ways in which such observations can be translated into improved lifelong health. A key approach is to identify early biomarkers of adverse health outcomes and then to test these, and subsequent interventions, in trials aimed at identifying strategies to optimise health throughout the life course. The ALPHABET project will inform this process for musculoskeletal outcomes, and the project as a whole should help elucidate not only novel mechanisms, but also potential strategies to reduce the burden of musculoskeletal, respiratory, neurodevelopmental and cardiometabolic disease in future generations.

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Pregnancy Vitamin D Supplementation and Childhood Bone Mass at Age 4 Years: Findings From the Maternal Vitamin D Osteoporosis Study (MAVIDOS) Randomized Controlled Trial

et al. 2022

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In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin D supplementation in pregnancy did not lead to greater neonatal bone mass across the trial as a whole, but, in a prespecified secondary analysis by season of birth, led to greater neonatal bone mass among winter-born babies. Demonstrating persistence of this effect into childhood would increase confidence in a long-term benefit of this intervention. We investigated whether antenatal vitamin D supplementation increases offspring bone mineralization in early childhood in a prespecified, single-center follow-up of a double-blinded, multicenter, randomized controlled clinical trial based in the UK (MAVIDOS). A total of 1123 women in early pregnancy with a baseline 25-hydroxyvitamin D level 25-100 nmol/L from three research centers (2008)(2009)(2010)(2011)(2012)(2013)(2014) were randomized to 1000 IU/d cholecalciferol or matched placebo from 14 weeks of gestation to delivery. Offspring born at the Southampton, UK research center were assessed at age 4 years (2013)(2014)(2015)(2016)(2017)(2018). Anthropometry and dual-energy X-ray absorptiometry (DXA) were performed (yielding whole body less head [WBLH] bone mineral content [BMC], areal bone mineral density [aBMD], bone area [BA], and body composition). Of 723 children, 564 (78.0%) children attended the 4-year visit, 452 of whom had a useable DXA. Maternal vitamin D supplementation led to greater WBLH aBMD in the children compared with placebo (mean [95% confidence interval {CI}]: supplemented group: 0.477 (95% CI, 0.472-0.481) g/cm 2 ; placebo group: 0.470 (95% CI, 0.466-0.475) g/cm 2 , p = 0.048). Associations were consistent for BMC and lean mass, and in age-and sex-adjusted models. Effects were observed across the whole cohort irrespective of season of birth. Maternal-child interactions were observed, with a greater effect size among children with low milk intake and low levels of physical activity. Child weight, height, and body massThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study

Cited by 43 publications

References 29 publications

Foetal, neonatal and child vitamin D status and enamel hypomineralization

Foetal, neonatal and child vitamin D status and enamel hypomineralization

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

Pregnancy Vitamin D Supplementation and Childhood Bone Mass at Age 4 Years: Findings From the Maternal Vitamin D Osteoporosis Study (MAVIDOS) Randomized Controlled Trial

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