Comparative evaluation of the combined application of titanium implants and calcium phosphate bone substitutes in a rabbit model

Alsayed, Arwa; Anil, Sukumaran; Jansen, John A.; Beucken, Jeroen J.J.P. van den

doi:10.1111/clr.12435

Cited by 7 publications

(3 citation statements)

References 45 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In in vitro studies, BCP displays biocompatibility (Bakhtiari et al, 2010;Bernhardt et al, 2011;Piccinini et al, 2016) which can promote the proliferation of osteoblasts (Bernhardt et al, 2013;Lomelino Rde et al, 2012) and mesenchymal stem cells (Lobo et al, 2015). In animal studies, BCP shows positive potential in bone regeneration capacities (Alsayed et al, 2015;Asvanund & Chunhabundit, 2012;Choi et al, 2011;Dahlin et al, 2015;Ezirganli et al, 2015;Khan et al, 2015;Lindhe et al, 2013;Macedo et al, 2014;Macedo et al, 2018;Mendoza-Azpur et al, 2015;Park et al, 2010;Piccinini et al, 2013;Suaid et al, 2013Suaid et al, , 2014Sungtae et al, 2011;Yazdi et al, 2013;Yip et al, 2015). In clinical studies BCP exhibits good results in terms of new bone formation and volume stability in maxillary sinus augmentations (Bettach et al, 2014;Chiu et al, 2018;Christer et al, 2009Christer et al, , 2012Covani et al, 2011;Danesh-Sani et al, 2016;Frenken et al, 2010;Helder et al, 2018;Iezzi et al, 2012;Lee et al, 2018;Mangano et al, 2013;Nishimura et al, 2018;Ohe et al, 2016;Okada et al, 2017;…”

Section: Introductionmentioning

confidence: 99%

Bone regeneration of a polymeric sponge technique—Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull

Intapibool

Monmaturapoj

Nampuksa

et al. 2021

Clinical & Exp Dental Res

View full text Add to dashboard Cite

Background: Polymeric sponge technique is recommended for developing the desired porosity of Biphasic calcium phosphate (BCP) which may favor bone regeneration.Purpose: To investigate the healing of BCP with ratio of HA30/β-TCP70 (HA30) and HA70/β-TCP30 (HA70) polymeric sponge preparation, compare to commercial BCP (MBCP+TM).Materials and Methods: Materials were tested X-ray diffraction (XRD) pattern and scanning electron microscope (SEM) analysis. In eight male pigs, six calvarial defects were created in each subject. The defects were the filled with 1 cc of autogenous bone, MBCP+TM (MBCP), HA30, HA70, and left empty (negative group). The new bone formations, residual material particles and bone-to-graft contacts were analyzed at 4, 8, 12 and 16 weeks.Results: Fabricated BCP showed well-distributed porosity. At 16 weeks, new bone formations were 45.26% (autogenous), 33.52% (MBCP), 24.34% (HA30), 19.43% (HA70) and 3.37% (negative). Residual material particles were 1.88% (autogenous), 17.58% (MBCP), 26.74% (HA30) and 37.03% (HA70). These values were not significant differences (Bonferroni correction <0.005). Bone-to-graft contacts were 73.68% (MBCP), which was significantly higher than 41.68% (HA30) and 14.32% (HA70; Bonferroni correction <0.017).Conclusions: Polymeric sponge technique offers well-distributed porosity. The new bone formation and residual material particles were comparable to MBCP+TM, but the bone-to-graft contact was lower than MBCP+TM.

show abstract

Section: Introductionmentioning

confidence: 99%

Bone regeneration of a polymeric sponge technique—Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull

Intapibool

Monmaturapoj

Nampuksa

et al. 2021

Clinical & Exp Dental Res

View full text Add to dashboard Cite

show abstract

“…Due to the excellent properties of BCPs, such as biocompatibility, bioactivity, and osteoconductivity, they have been investigated for a range of biomedical applications in bone tissue engineering. In addition, BCPs have shown promising results for bone tissue growth and osseointegration …”

Section: Introductionmentioning

confidence: 99%

“…Alsayed et al and Preethanath et al have studied the simultaneous placement of CaP bone grafts and metallic implants in a rabbit femoral condyle defects model. In this study, a novel strategy involving BCPs block bone substitutes with simultaneous implant placement for mandibular reconstruction has been proposed, which is expected to have great potential for treating mandibular bone defects in the clinic.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of mandibular bone defects using biphasic calcium phosphate bone substitutes with simultaneous implant placement in mini‐swine: A pilotin vivostudy

Zhang

Wang

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

This study aimed to investigate implant osseointegration using a new strategy of biphasic calcium phosphate (BCP) bone substitutes with simultaneous implant placement in mandibular reconstruction. Additionally, the temporal transcriptional profile associated with the early biological processes during osseointegration was determined. BCP and hydroxyapatite (HA) bone substitutes with simultaneous implant placement were grafted into mandibular defects created in mini-swine. Radiographic, histological, and biochemical analyses were applied for evaluation of osseointegration effects at 4 months after the grafting procedure. Bone formation around the implant was assessed by the bone area percentage (BA%) and the bone-implant-contact percentage (BIC %). The biomechanical evaluation was performed by the implant pullout test and the removal torque test. Microarray technology was utilized for gene expression comparison analysis at day 14 postoperatively. Radiographic and histological observation indicated enhanced bone formation in the BCP group compared to the HA group. Histomorphometric analyses of BA% and BIC% as well as biochemical analyses of the maximal pull-out force and the ultimate shear strength were all significantly greater in the BCP group (p < 0.05). Transcriptional analysis at an early stage of osseointegration revealed that genes belonging to biological processes associated with cell proliferation, development, osteogenesis, angiogenesis, and neurogenesis as well as the osteogenesis-related TGF-β/BMP and WNT signaling pathways were upregulated in the BCP group. In conclusion, the reconstruction of mandibular defects using BCP with simultaneous implant placement resulted in superior osseointegration effects. A number of candidate genes that were differentially expressed may contribute to the superior osseointegration effects.

show abstract

Bone response to calcium phosphate coatings for dental implants

Anil

Venkatesan

Shim

et al. 2017

Bone Response to Dental Implant Materials

View full text Add to dashboard Cite

Comparative evaluation of the combined application of titanium implants and calcium phosphate bone substitutes in a rabbit model

Abstract: The addition of BCP bone substitute to fill peri-implant gaps significantly enhanced both bone formation (~2.5-fold) and bone to implant contact (>2-fold) for the custom-made titanium implants with two-sided gaps.

Cited by 7 publications

References 45 publications

Bone regeneration of a polymeric sponge technique—Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull

Bone regeneration of a polymeric sponge technique—Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull

Reconstruction of mandibular bone defects using biphasic calcium phosphate bone substitutes with simultaneous implant placement in mini‐swine: A pilotin vivostudy

Bone response to calcium phosphate coatings for dental implants

Contact Info

Product

Resources

About