Cryoprotective therapy for hepatocellular carcinoma: Study of 51 patients with a single lesion

Alnaggar, Mohammed; Niu, Lizhi; Li, Jialiang; Yao, Fei; Wang, Yuan; Zhang, Jianying; Chen, Jibing; Feng, Ming; Xu, Kecheng

doi:10.1016/j.cryobiol.2014.05.003

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, and its incidence is increasing [1]. In 80% of patients, HCC is associated with chronic liver diseases such as hepatitis or cirrhosis, which have major effects on prognosis and therapeutic preferences [2].…”

Section: Introductionmentioning

confidence: 99%

Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

Alnaggar

Lin

Mesmar

et al. 2018

Cell Physiol Biochem

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Background/Aims: We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepatocellular carcinoma (HCC). Methods: The study involved 40 patients with stage IV HCC who were divided equally into two groups: 1) simple IRE; and 2) IRE plus allogenic NK cells (IRE-NK); we mainly assessed the overall survival (OS). Results: The effect of the IRE-NK treatment was synergistic, i.e., not only did it enhance immune function, it also decreased alpha-fetoprotein expression and showed significantly good clinical effectiveness. At the median 7.6-month follow-up (range, 3.8–12.1 months), median OS was higher in the IRE-NK group (10.1 months) than in the IRE group (8.9 months, P = 0.0078). Conclusion: IRE combined with allogeneic NK cell immunotherapy significantly increases the median OS of patients with stage IV HCC.

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Section: Introductionmentioning

confidence: 99%

Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

Alnaggar

Lin

Mesmar

et al. 2018

Cell Physiol Biochem

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“…For smaller lesions, it can also clearly show the edge of the lesion and its adjacent vascular structure. Particularly near the diaphragm of the lesion, hilar large vessels and other special locations, the 64-slice spiral CT provides a clear image that enables physicians reduce intraoperative time, avoid damage to the surrounding normal tissues, and limits the freezing range; which affects the influence of the ablation[37-40]. 64-slice spiral imaging can directly reflect the internal hemodynamics of the liver, and has good reference value for understanding tumor angiogenesis and its biological characteristics [11,41-44].…”

Section: Discussionmentioning

confidence: 99%

Observation of the effect of targeted therapy of 64-slice spiral CT combined with cryoablation for liver cancer

Yan¹,

Xu²,

Shen³

et al. 2017

WJG

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AIMTo observe the effect of targeted therapy with 64-slice spiral computed tomography (CT) combined with cryoablation for liver cancer.METHODSA total of 124 patients (142 tumors) were enrolled into this study. According to the use of dual-slice spiral CT or 64-slice spiral CT as a guide technology, patients were divided into two groups: dual-slice group (n = 56, 65 tumors) and 64-slice group (n = 8, 77 tumors). All patients were accepted and received targeted therapy by an argon-helium superconducting surgery system. The guided scan times of the two groups was recorded and compared. In the two groups, the lesion ice coverage in diameter of ≥ 3 cm and < 3 cm were recorded, and freezing effective rate was compared. Hepatic perfusion values [hepatic artery perfusion (HAP), portal vein perfusion (PVP), and the hepatic arterial perfusion index (HAPI)] of tumor tissues, adjacent tissues and normal liver tissues at preoperative and postoperative four weeks in the two groups were compared. Local tumor changes were recorded and efficiency was compared at four weeks post-operation. Adverse events were recorded and compared between the two groups, including fever, pain, frostbite, nausea, vomiting, pleural effusion and abdominal bleeding.RESULTSGuided scan times in the dual-slice group was longer than that in the 64-slice group (t = 11.445, P = 0.000). The freezing effective rate for tumors < 3 cm in diameter in the dual-slice group (81.58%) was lower than that in the 64-slice group (92.86%) (χ2 = 5.707, P = 0.017). The HAP and HAPI of tumor tissues were lower at four weeks post-treatment than at pre-treatment in both groups (all P < 0.05), and those in the 64-slice group were lower than that in the dual-slice group (all P < 0.05). HAP and PVP were lower and HAPI was higher in tumor adjacent tissues at post-treatment than at pre-treatment (all P < 0.05). Furthermore, the treatment effect and therapeutic efficacy in the dual-slice group were lower than the 64-slice group at four weeks post-treatment (all P < 0.05). Moreover, pleural effusion and intraperitoneal hemorrhage occurred in patients in the dual-slice group, while no complications occurred in the 64-slice group (all P < 0.05).CONCLUSION64-slice spiral CT applied with cryoablation in targeted therapy for liver cancer can achieve a safe and effective freezing treatment, so it is worth being used.

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“…Hepatocellular carcinoma (HCC) is a common tumor worldwide and its incidence rate is increasing (1). Of the affected patients, 80% have chronic liver diseases such as hepatitis or cirrhosis; the presence of these conditions in conjunction with HCC has a major effect on the prognosis and treatment of this type of cancer (2) Currently, percutaneous ablation therapies, including percutaneous ethanol injection, microwave coagulation and radiofrequency ablation, are available and are important therapeutic modalities for the treatment of HCC (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Irreversible electroporation of malignant liver tumors: Effect on laboratory values

et al. 2018

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Liver cancer is often associated with chronic liver diseases. Treatment with percutaneous irreversible electroporation (IRE) may preserve liver function. In the present study, the clinical data of 29 patients with liver tumors between July 2015 and December 2016, all of whom underwent liver IRE at Fuda Cancer Hospital, Guangzhou, China was retrospectively reviewed. All the patients survived the treatment. Of the 29 patients, 7 were positive for hepatitis B, 15 had hepatocellular carcinoma (HCC) and 7 had pancreatic cancer with liver metastases. All patients survived IRE. Despite liver-protective treatment prior to IRE, the mean alanine transaminase (ALT) and aspartate transaminase (AST) levels were significantly elevated 1-2 days after IRE, to 540 and 712 U/l, respectively; however they had returned to the preoperative values by 2 weeks following IRE. Prior to IRE, the mean total bilirubin and direct bilirubin measurement levels were normal; however, 8-10 days after IRE, they had increased to 24 U/l and 12 µmol/l, respectively, and had returned back to the preoperative levels by 2 weeks after IRE. This first group included all patients. The result of the 4 subgroups of cancer patients demonstrated a variation between different measurement days and recovery with patients positive for the hepatitis B virus taking the longest duration to recover (17±3 days) meanwhile patients with pancreatic cancer with liver metastases took the shortest time to achieve recovery (10.78±2 days). The findings of the present study indicate that hepatic injury caused by IRE is transient and self-limiting in patients with liver tumors.

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Cryoprotective therapy for hepatocellular carcinoma: Study of 51 patients with a single lesion

Cited by 8 publications

References 25 publications

Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

Observation of the effect of targeted therapy of 64-slice spiral CT combined with cryoablation for liver cancer

Irreversible electroporation of malignant liver tumors: Effect on laboratory values

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