Respiratory Infection with Enterovirus Genotype C117, China and Mongolia

Zou, Xiang; Tsatsral, Sosorbaramyn; Liu, Chunyan; Li, Linlin; Ren, Lili; Xiao, Yan; Xie, Zhengde; Zhou, Hongli; Vernet, Guy; Nymadawa, Pagbajabyn; Shen, Kunling; Wang, Jianwei

doi:10.3201/eid.2006.131596

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Other enteroviruses have been associated with respiratory illnesses. For example, enterovirus C117, first identified in a child with pneumonia in Lithuania in 2012, has been found in different countries since and might be associated with respiratory tract infections ( Xiang et al, 2014 ; Van Leer-Buter et al, 2016 ). Also, human enterovirus 71 (EV-71) is a known etiological agent of hand, foot, and mouth disease and associated with neurological complications.…”

Section: Discussionmentioning

confidence: 99%

Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada

et al. 2017

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Despite its first appearance in 1962, human enterovirus D68 (EV-D68) has been recognized as an emerging respiratory pathogen in the last decade when it caused outbreaks and clusters in several countries including Japan, the Philippines, and the Netherlands. The most recent and largest outbreak of EV-D68 associated with severe respiratory illness took place in North America between August 2014 and January 2015. Between September 1 and October 31 2014, EV-D68 infection was laboratory confirmed among 153/907 (16.9%) persons tested for the virus in Ontario, Canada, using real time RT-PCR and subsequent genotyping by sequencing of partial VP1 gene. In order to understand the evolutionary history of the 2014 North American EV-D68 outbreak, we conducted phylogenetic and phylodynamic analyses using available partial VP1 genes (n = 469) and NCBI available whole genome sequences (WGS) (n = 38). The global EV-D68 phylogenetic tree (n = 469) reconfirms the divergence of three distinct clades A, B, and C from the prototype EV-D68 Fermon strain as previously documented. Two sub-clades (B1 and B2) were identified, with most 2014 EV-D68 outbreak strains belonging to sub-cluster B2b2 (one of the two emerging clusters within sub-clade B2), with two signature substitutions T650A and M700V in BC and DE loops of VP1 gene, respectively. The close homology between WGS of strains from Ontario (n = 2) and USA (n = 21) in the recent EV-D68 outbreak suggests genetic relatedness and also a common source for the outbreak. The time of most recent common ancestor of EV-D68 and the 2014 EV-D68 outbreak strain suggest that the viruses possibly emerged during 1960–1961 and 2012–2013, respectively. We observed lower mean evolutionary rates of global EV-D68 using WGS data than estimated with partial VP1 gene sequences. Based on WGS data, the estimated mean rate of evolution of the EV-D68 B2b cluster was 9.75 × 10-3 substitutions/site/year (95% BCI 4.11 × 10-3 to 16 × 10-3).

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Section: Discussionmentioning

confidence: 99%

Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada

et al. 2017

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“…Some enteroviruses that cannot grow in RD and HEp-2 cells may have been missed in this study. For instance, most of the newly identified EV-C such as EV-C104, -C105, -C109, -C113, -C116, C117, and -C118 were not reported by viral isolation in cell culture 7 8 9 10 45 46 47 48 . However, our research team tried to extract RNA directly from part of the stool suspensions, and screened such RNA with published pan EV-C primers (primer pairs 494 and 496; 495 and 497) 5 , and did not find above mentioned novel EV-Cs.…”

Section: Discussionmentioning

confidence: 99%

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

Zhang¹,

Sun²,

Cui

et al. 2016

Sci Rep

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Poliomyelitis associated with circulating vaccine-derived polioviruses (cVDPVs) is a serious public health issue in the post-eradication era, and the occurrence of recombinant cVDPVs emphasizes the need to elucidate enterovirus C (EV-C) epidemiology. Stool samples were collected from 826 healthy children in Southern Xinjiang in 2011 to investigate EV-C circulation and epidemiology. Thirty-six EV-Cs were isolated and assigned to eight EV-C serotypes by molecular serotyping, suggesting the circulation of diverse EV-Cs in Xinjiang. Phylogenetic analysis showed that the Xinjiang EV-C strains had larger variation compared to the prototype and other modern strains. Additionally, the results showed unique characteristics of Xinjiang EV-Cs, such as the cytopathicity of CV-A1 strains to RD cells; the high divergence in CV-A11, CV-A13, CV-A17, and CV-A20 strains; the divergence of Xinjiang CV-A24 from AHC-related CV-A24 variant stains distributed worldwide; and the circulation of two novel EV-C serotypes (EV-C96 and EV-C99). Evaluations of this dense and diverse EV-C ecosystem will help elucidate the processes shaping enteroviral biodiversity. This study will improve our understanding of the evolution of enteroviruses and the recombination potential between polioviruses and other EV-Cs.

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Identification and complete genome characterization of human enterovirus 117 from a child with pneumonia in China

Zhu

Zhuang

et al. 2019

Arch Virol

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In this study, human enterovirus C117 (EV-C117) was detected in a 3-month-old boy diagnosed with pneumonia in China. A phylogenetic analysis showed that this strain was genetically closer to the Lithuanian strain than to the USA strain. The genus Enterovirus of the family Picornaviridae consists of 15 species, including Enterovirus A-L and Rhinovirus A-C (http://www.picor navir idae.com). Enteroviruses (EVs) AD and human rhinoviruses (HRVs) A-C infect humans and mostly affect children under one year of age. EV infections cause a variety of diseases with various clinical manifestations, ranging from mild febrile illness to severe systemic infections [5, 7]. Human enterovirus 117 (EV-C117), which belongs to the species Enterovirus C [1], was first identified in Lithuania in 2012 in a nasopharyngeal sample collected from a

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Respiratory Infection with Enterovirus Genotype C117, China and Mongolia

Abstract: A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shigatoxigenic Escherichia coli O104:H4.

Cited by 4 publications

References 8 publications

Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada

Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

Identification and complete genome characterization of human enterovirus 117 from a child with pneumonia in China

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