Biomarkers Associated with Obesity and Overweight in the Roma Population Residing in Eastern Slovakia

Petrášová, Darina; Bertková, Izabela; Petrášová, Miroslava; Hijová, Emília; Mareková, Mária; Babinská, Ingrid; Jarčuška, Peter; Pella, Daniel; Gecková, Andrea Madarasová

doi:10.21101/cejph.a3896

Cited by 9 publications

(7 citation statements)

References 19 publications

(16 reference statements)

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“…Here, the gastric leptinR and leptin mRNA are elevated in obese individuals. Our findings within the gastric tissue are in line with the dramatically increased leptin level in serum, as found here and in previous studies . In the stomach, leptin and leptin receptor mRNA, as well as the serum level of leptin, are elevated in obese humans.…”

Section: Discussionsupporting

confidence: 93%

Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity

Ritze

Schollenberger

Sinno

et al. 2016

Neurogastroenterology Motil

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Section: Discussionsupporting

confidence: 93%

Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity

Ritze

Schollenberger

Sinno

et al. 2016

Neurogastroenterology Motil

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“…Obese Roma people had larger waist circumference, hip circumference, waist to hip ratio, lower levels of HDL cholesterol, adiponectin, and higher levels of triacylglyceroles. Furthermore, inflammatory parameters (CRP and TNF alpha) were elevated in this population (19). Prevalence of metabolic syndrome increases with age.…”

Section: Editorial Low Socioeconomic Status and Unhealthy Lifestyle Lmentioning

confidence: 65%

Low Socioeconomic Status and Unhealthy Lifestyle Lead to High Morbidity in Young Roma of East Slovakia

Sedláková¹

2014

Cent Eur J Public Health

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Roma people constitute one of the oldest and largest minorities in Europe. In Slovakia, there are approximately 400,000 Roma, and represent 7.5% of total population (1). However, according to recent official census in 2010, only 105,738 (2% of total population) citizens declared themselves as Roma ethnic. Approximately one sixth of Roma people live in segregated settlements (1). This supplement contains results of the HepaMeta study, which has aimed to map the socioeconomic, lifestyle, selected anthropometric, and health-related aspects of young Roma people living in the settlements and their majority counterparts. This study was conducted in 2011 and its main goal was to explore the prevalence of hepatitis B and C and metabolic syndrome. A group of 452 Roma aged 18-55 years, living in settlements (mean age = 34.7; 35.2% men) was compared to a control group of 403 non-Roma randomly chosen (mean age = 33.5; 45.9% men) from the patient database of collaborating general practitioners. Data were obtained by questionnaire, anthropometric measures and analysed blood and urine samples (2). Roma population from segregated settlements live in significantly worse socioeconomic conditions compared to the majority, they have significantly worse education and higher unemployment rate. More than 80% of Roma have only basal education, higher education was attained by only 2.3% of this group compared to the majority population in which almost 80% completed higher education. More than 90% of Roma people are unemployed. Unemployment rate in the majority population in the studied East Slovakia region is approximately 25%. Two thirds of Roma people, but only 7.2% of the majority population receive social allowances. Approximately two thirds of Roma and one in 25 persons of the majority population cannot pay collection orders and current expenditures. Significant differences have been also found in the standard of living. Just half of Roma people have a stable water supply, toilet, bathroom or shower, whereas in the majority these utilities are available up to 95% of persons. One sixth of Roma people have no electricity (3). Significant differences were also demonstrated in the lifestyle of these groups. Roma men and women have less physical activity (sports, dance, walking) compared to the majority. On the other hand, higher physical activity associated with household was documented in Roma women, which is probably associated with higher number of children in Roma families. Roma people smoke cigarettes more often and are heavy smokers compared to the majority population. Alcohol use among Roma men was comparable to non-Roma men, but Roma women reported lower use of alcohol compared to the majority (4). People from segregated Roma settlements also reported unhealthy diet. They reported eating less fruits, vegetables and dairy products. Roma women reported higher consumption of meat and soft drinks. These differences in eating habits could be associated with higher prevalence of metabolic syndrome in younger age (5). Several significa...

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“…Dos itens que compõem a MetS, os níveis de HDLcolesterol foram os mais alterados (83% dos homens 6 Os níveis de insulina dos pacientes avaliados foram normais, sem diferença significativa entre os grupos, apesar de os mesmos terem circunferência de cintura aumentada, o que contraria algumas afirmativas da proporcionalidade entre adiposidade e insulinemia. 17 Diferente dos nossos achados, Geliebter e colaboradores 18 , comparando pacientes com e sem compulsão alimentar, encontraram níveis significativamente maiores de insulina naqueles com compulsão, indicando ser o transtorno alimentar fator determinante na concentração hormonal.…”

Section: Resultsunclassified

“…Vários biomarcadores inflamatórios têm sido propostos para avaliar o risco cardiovascular (RCV) na obesidade, como citocinas pró e anti-inflamatórias, adipocinas e enzimas, em geral associados à distribuição de gordura corporal e ao Índice de Massa Corpórea (IMC). 6 Dentre os biomarcadores inflamatórios mais estudados, encontram-se a leptina e adiponectina.…”

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Características antropométricas e metabólicas em obesos com transtorno alimentar

Silva¹,

Magalhães²,

Oliveira³

et al. 2015

Revista Hospital Universitário Pedro Ernesto

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O transtorno de compulsão alimentar periódica (TCAP) é um distúrbio psiquiátrico com alta morbidade, associado à obesidade e ao alto risco cardiovascular. O objetivo deste trabalho foi identificar alterações antropométricas e/ou metabólicas em obesos com TCAP e compará-las àqueles sem TCAP. Estudo transversal realizado no ambulatório do Napta/ UERJ, envolvendo 39 adultos obesos, sem doenças malignas ou consumptivas e medicamentos que interferissem nos resultados, sendo 22 com e 17 sem TCAP. As variáveis coletadas foram peso, estatura, perímetro da cintura, pressão arterial; e foram analisadas glicemia, perfil lipídico, dosagem de leptina, adiponectina e insulina, sendo calculado o Índice HOMA IR. Os dados foram expressos como média (desvio-padrão), sendo utilizados os testes: Qui-quadrado e t-Student. O valor de significância foi 5%. Amostra composta por 82% de mulheres, com elevada prevalência de hipertensão arterial, resistência insulínica e sedentarismo, sem diferenças entre os grupos com ou sem TCAP. Todos apresentaram o perímetro da cintura acima da recomendação, mais de 60% apresentaram HDL-colesterol baixo e um terço, triglicerídeos elevados. Não houve diferença dos níveis de adiponectina nem de leptina entre obesos com ou sem TCAP, apesar de os valores estarem fora dos limites normais. Obesos, independentemente do diagnóstico de TCAP, têm elevado risco cardiovascular com alta prevalência de hipertensão arterial, dislipidemia, circunferência de cintura alterada e sedentarismo. Além disso, apresentam inflamação crônica de baixo grau com baixos níveis de adiponectina e altos de leptina. Entretanto, apesar de estas afirmativas terem sido confirmadas, não foram identificadas diferenças significativas entre obesos com o transtorno alimentar.Descritores: Obesidade; Adulto; Doenças cardiovasculares. Abstract Anthropometric and metabolic characteristic in obese patient with eating binge disorderThe binge eating disorder (BED), is a psychiatric disturb with great morbidity, is associated with obesity and increased risk of the cardiovascular diseases. As few studies were published in BED, the objective of this research was to identify anthropometric and metabolic in this group and compare with no BED obesity. A cross-sectional study was performed in the ambulatory of Napta/UERJ with 39 obese adults (BMI ≥ 30 kg/ m2) with no malignancy, consumptive disease nor taking any medicine that could interfere with the results were evaluated. waist circumference, blood pressure, glycemic, leptin, adiponectin, insulin level and lipidogram were assessed. IR HOMA identified insulin resistance. The data were expressed as mean (standard deviation). Chi-square and t-Student tests were performed. The significance level was of 5%. Sample composed of 82% women, with a high prevalence of hypertension, insulin resistance and sedentary lifestyle, with no differences between the groups with or without BED. All the participants presented the waist measurement above the recommendation; more than 60% had low HDL cholesterol and a third of th...

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Biomarkers Associated with Obesity and Overweight in the Roma Population Residing in Eastern Slovakia

Cited by 9 publications

References 19 publications

Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity

Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity

Low Socioeconomic Status and Unhealthy Lifestyle Lead to High Morbidity in Young Roma of East Slovakia

Características antropométricas e metabólicas em obesos com transtorno alimentar

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