Decrease in the percentage of peripheral blood CXCR3highCD4+ lymphocytes after renal transplantation

Caballero, Abelardo; Ruiz-Esteban, Pedro; Palma, Eulalia; Ramirez, Paloma; Fuentes, Laura; Sola, E.; Rudas, Edisson; Alonso, Angela; Hernández, Domingo

doi:10.1016/j.trim.2014.05.001

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Several studies highlighted the role of the lymphocytes migration in the transplant outcome, since the lymphocyte infiltration into the allograft, which is related to chemokines and chemokine receptors, may result in allograft dysfunction and finally its rejection. It was found that T cells expressing chemokine (C-X-C motif) receptor 3 (CXCR3), chemokine (C-C motif) receptor (CCR) 1, and CCR4 might have predictive value for transplant outcome (Caballero et al, 2014;Foroughi et al, 2016).…”

Section: T Cell In Kidney Transplant Outcomementioning

confidence: 99%

See 1 more Smart Citation

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Mirzakhani

Shahbazi

Oliaei

et al. 2018

Journal Cellular Physiology

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The half-life of transplanted kidneys is <10 years. Acute or chronic rejections have a negative impact on transplant outcome. Therefore, achieving to allograft tolerance for improving long-term transplant outcome is a desirable goal of transplantation field. In contrast, there are evidence that distinct immunological characteristics lead to tolerance in some transplant recipients. In contrast, the main reason for allograft loss is immunological responses. Various immune cells including T cells, B cells, dendritic cells, macrophages, natural killer, and myeloid-derived suppressor cells damage graft tissue and, thereby, graft loss happens. Therefore, being armed with the comprehensive knowledge about either preimmunological or postimmunological characteristics of renal transplant patients may help us to achieve an operational tolerance. In the present study, we are going to review and discuss immunological characteristics of renal transplant recipients with rejection and compare them with tolerant subjects.

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Section: T Cell In Kidney Transplant Outcomementioning

confidence: 99%

“…T-cell, as well as B-cell responses, mainly culminated in graft rejection (Wekerle et al, 2017). Alloreactive T cells are involved in graft failure have predictive value for transplant outcome (Caballero et al, 2014;Foroughi et al, 2016).…”

Section: T Cell In Kidney Transplant Outcomementioning

confidence: 99%

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Mirzakhani

Shahbazi

Oliaei

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…The proof of this phenomenon is found in evidence of elevated levels of peripheral markers of immune activation (e.g., cytokines and chemokines) [25,26,27,28,29,30,31,32]. Other proinflammatory cell products, like NGAL [13], galectin-3 (GAL-3) [33,] and Lp-PLA 2 [34], the first released by polymorphonuclear leukocytes and the others by macrophages, have been shown to be augmented as well.…”

Section: Adaptive and Innate Immunity Abnormalities In Esrdmentioning

confidence: 99%

Targeting Immunity in End-Stage Renal Disease

2017

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Background: Despite the stable incidence of end-stage renal disease (ESRD), it continues to be associated with an unacceptably high cardiovascular risk. Summary: ESRD is characterized by enhanced oxidative stress and severe inflammation, which boost cardiovascular risk, thus increasing cardiovascular-associated mortality rate. While substantial effort has been made in the technological innovation of dialytic techniques, few significant advances have been made to reduce inflammation in patients with ESRD. Indeed, this contrasts with the extensive scientific breakthroughs made in the basic field of science in targeting inflammation. There is thus a pressing need for clinical trials to test the effect of reducing inflammation in patients with ESRD. Here, we will revisit the negative effect of ESRD on inflammation and explore the impact of enhanced inflammation on cardiovascular outcomes and survival in patients with ESRD. Finally, we will discuss the need for clinical trials that target inflammation in ESRD, as well as weigh potential disadvantages and offer novel innovative approaches. Key Message: We will try to understand why the issue of inflammation has not been successfully addressed thus far in patients with ESRD, while at the same time weighing the potential disadvantages and offering novel innovative approaches for targeting inflammation in patients with ESRD.

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CXCR3 + Monocytes Increase Significantly in Graft Blood Compared to Peripheral Blood in Patients With Stable Kidney Graft Function

Caballero

Palma

Ruiz-Esteban

et al. 2018

Transplantation Proceedings

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Decrease in the percentage of peripheral blood CXCR3highCD4+ lymphocytes after renal transplantation

Cited by 5 publications

References 8 publications

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Targeting Immunity in End-Stage Renal Disease

CXCR3 + Monocytes Increase Significantly in Graft Blood Compared to Peripheral Blood in Patients With Stable Kidney Graft Function

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