Contrast sensitivity in relapsing–remitting multiple sclerosis assessed by sine-wave gratings and angular frequency stimuli

Vieira-Gutemberg, Jákina G.; Mendes-Santos, Liana Chaves; Galdino, Melyssa Kellyane Cavalcanti; Santos, Natanael Antônio dos; Simas, Maria Lúcia de Bustamante

doi:10.1017/s0952523814000182

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Our findings bear similarity to contrast sensitivity deficits recently reported for multiple sclerosis (MS) [22]. MS is an inflammatory, neurodegenerative autoimmune disease [30].…”

Section: Discussionsupporting

confidence: 91%

“…Optic neuritis is common [31] along with reports of loss of vision, colour vision disturbances, pain in the eyes, blurred vision, and visual fatigue [30,31]. A number of studies have examined contrast sensitivity in MS, and although the spatial frequency specificity varies between studies, there is agreement that poor contrast sensitivity is associated with the condition [20,21,22]. MS and ME share phenomenology and neuroimmune characteristics [32].…”

Section: Discussionmentioning

confidence: 99%

“…Changes in contrast sensitivity are well documented in ageing [17] and are evident in a range of retinal diseases [18]. They are also present in neurodegenerative diseases such as Parkinson’s disease [19] and in inflammatory autoimmune diseases such as multiple sclerosis [20,21,22]. Contrast sensitivity deficits can be present even when there is no detectable impairment in visual acuity.…”

Section: Introductionmentioning

confidence: 99%

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Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME)

Ahmed

Gottlob

Proudlock

et al. 2018

Vision

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Myalgic encephalomyelitis (ME) is a devastating disorder marked by debilitating fatigue. It not well understood and its diagnosis is controversial. It is very important therefore that significant clinical features are investigated. Visual symptoms in ME represent a group of distinct, quantifiable, clinical features that could significantly improve diagnosis and provide insights into underlying pathology. The purpose of the present study was therefore to explore the effect of ME on spatial windows of visibility using the spatial contrast sensitivity function. Contrast sensitivity was determined for stationary luminance-defined sinusoidal gratings spanning a five-octave range of spatial frequencies (0.5 to 16 c/deg) in a group of 19 individuals with ME and a group of 19 matched (age, gender) controls. Compared to controls, the ME group exhibited a restricted spatial window of visibility for encoding stimulus contrast. This was characterised principally by a contrast sensitivity deficit at lower spatial frequencies and a narrower bandwidth. Our findings suggest that contrast sensitivity deficits may represent a visual marker of ME, and be indicative of abnormal visual processing at the level of the retina and in the cortical and subcortical visual pathways.

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“…Our findings bear similarity to contrast sensitivity deficits recently reported for multiple sclerosis (MS) [22]. MS is an inflammatory, neurodegenerative autoimmune disease [30].…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME)

Ahmed

Gottlob

Proudlock

et al. 2018

Vision

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“…Measures of low-contrast vision and CSV were sensitive to visual impairment, even in patients with VA of 20/20 or better (measured with a Snellen chart), and have been correlated with poorer performances in everyday tasks [8, 17–20]. Our patients presented reduced CSV in low and midspatial frequencies and low-contrast VA compared with healthy controls, which is consistent to previous research involving classic visual function tests [11, 21, 22] and tests performed with other video processors [23, 24]. However, high spatial frequencies were not significantly affected in our patients, contrary to previous findings [11, 24].…”

Section: Discussionsupporting

confidence: 89%

Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor

Satué

Jarauta

Obís

et al. 2019

Journal of Ophthalmology

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Objectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). Results. Patients with MS presented reduced low-contrast VA (p<0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (≤0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p<0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. Conclusions. Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.

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“…Many studies demonstrated that deterioration in contrast sensitivity, visual field, and RNFL thickness may cause difficulty in a patient’s daily life. 18 – 23 So, in the present study, radiation dose–volume damage relation on anterior visual pathways was evaluated by visual field, contrast sensitivity, RNFL thickness, VEP latency, and VEP amplitude measurements besides VA.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Radiation Dose–Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinoma

Akagündüz

Yılmaz

Yalman

et al. 2017

Technol Cancer Res Treat

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Purpose:To evaluate the radiation dose–volume effects of optic nerves and chiasm by visual psychophysical, electrophysiologic tests, and optical coherence tomography in patients with locally advanced nasopharyngeal carcinoma.Materials and Methods:A series of visual tests including visual acuity, visual field, contrast sensitivity, visual evoked potential, and optical coherence tomography were administered to 20 patients with locally advanced (T3-T4) nasopharyngeal carcinoma who were treated with definitive chemoradiotherapy. Volume that received 55 Gy (V55), mean dose (D mean), highest dose to 5% of the volume (D5), and maximum dose (Dmax) for optic nerves and chiasm were evaluated for each patient. Cutoff values were identified as V55: 50%, Dmean: 50 Gy, D5: 55 Gy, and Dmax: 60 Gy. The effects of radiation dose–volume on ophthalmologic tests were evaluated.Results:Ophthalmological evaluation revealed optic neuropathy with simultaneous retinopathy in 6 eyes of 4 patients and radiation retinopathy alone in both eyes of 1 patient. Regarding radiation dose–volume effects of the optic nerve, significant detrimental effect of all parameters was observed on visual acuity. Visual field and contrast sensitivity were affected significantly with V55 ≥ 50% and Dmean ≥ 50 Gy. Visual evoked potential latency was affected significantly with Dmean ≥ 50 Gy, D5 ≥ 55 Gy, and Dmax ≥ 60 Gy. For the chiasm, significant detrimental effect of all parameters was observed on visual acuity as well. Retinal nerve fiber layer thickness and visual evoked potential amplitude were not affected by any of the dose–volume parameters neither optic nerves nor chiasm.Conclusion:The volume receiving the threshold dose, mean dose, and 5% of the volume receiving the maximum dose are important parameters besides maximum dose to optic nerves and chiasm. A comprehensive ophthalmological evaluation including visual field, contrast sensitivity, visual evoked potential latency, and amplitude should be performed for these patients. Visual evoked potential latency is an objective predictor of vision loss before the onset of clinical signs.

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Contrast sensitivity in relapsing–remitting multiple sclerosis assessed by sine-wave gratings and angular frequency stimuli

Cited by 8 publications

References 40 publications

Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME)

Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME)

Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor

Evaluation of the Radiation Dose–Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinoma

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