Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME)

Ahmed, Nadia Sultana; Gottlob, Irène; Proudlock, Frank A; Hutchinson, Claire V.

doi:10.3390/vision2010002

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…are clearly altered for many affected by ME/CFS compared to controls [ 60 ]. We can also find an inability to focus vision, hypersensitivity to light [ 61 ], noise, vibration, smell, taste, and touch, as well as alterations in depth perception, muscle weakness, spasms, poor coordination, a feeling of instability, and ataxia [ 18 ].…”

Section: Dysautonomiamentioning

confidence: 99%

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?

et al. 2021

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disorder of unknown physiopathology with multisystemic repercussions, framed in ICD-11 under the heading of neurology (8E49). There is no specific test to support its clinical diagnosis. Our objective is to review the evidence in neuroimaging and dysautonomia evaluation in order to support the neurological involvement and to find biomarkers serving to identify and/or monitor the pathology. The symptoms typically appear acutely, although they can develop progressively over years; an essential trait for diagnosis is “central” fatigue together with physical and/or mental exhaustion after a small effort. Neuroimaging reveals various morphological, connectivity, metabolic, and functional alterations of low specificity, which can serve to complement the neurological study of the patient. The COMPASS-31 questionnaire is a useful tool to triage patients under suspect of dysautonomia, at which point they may be redirected for deeper evaluation. Recently, alterations in heart rate variability, the Valsalva maneuver, and the tilt table test, together with the presence of serum autoantibodies against adrenergic, cholinergic, and serotonin receptors were shown in a subgroup of patients. This approach provides a way to identify patient phenotypes. Broader studies are needed to establish the level of sensitivity and specificity necessary for their validation. Neuroimaging contributes scarcely to the diagnosis, and this depends on the identification of specific changes. On the other hand, dysautonomia studies, carried out in specialized units, are highly promising in order to support the diagnosis and to identify potential biomarkers. ME/CFS orients towards a functional pathology that mainly involves the autonomic nervous system, although not exclusively.

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Section: Dysautonomiamentioning

confidence: 99%