Magnetic hyperthermia efficiency in the cellular environment for different nanoparticle designs

Corato, Riccardo Di; Espinosa, Ana; Lartigue, Lénaïc; Tharaud, Mickaël; Chat, Sophie; Pellegrino, Teresa; Ménager, Christine; Gazeau, Florence; Wilhelm, Claire

doi:10.1016/j.biomaterials.2014.04.036

Cited by 361 publications

(384 citation statements)

References 41 publications

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“…Internalized MNP are partly immobilized and tightly packed inside vesicles [5]. Recently, it was shown that intracellular MNP generate less heating in MFH processes than free MNP in suspension [6]. This finding is contradicted, however, by the evidence that MNP agglomerations cause an amplified heating [7].…”

Section: Introductioncontrasting

confidence: 49%

Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia

Engelmann

Buhl

Baumann

et al. 2017

Current Directions in Biomedical Engineering

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Magnetic fluid hyperthermia (MFH) is a promising approach for organ-confined tumor treatment. In MFH, magnetic nanoparticles (MNP) are magnetically targeted at the tumor site and heated in an alternating magnetic field. The heat produced by the MNP is used to cause tumor cell death. At the tumor site, MNP bind to the cell membrane and form agglomerates before they are internalized into the intracellular compartments. Intracellular immobilization and the formation of agglomerates influence heating properties of MNP making it difficult to control the local heating inside the tumor. In this study, we investigated MNP agglomerated samples for their heating efficiency. We found an increase in heating of 22 % upon agglomeration. If MNP are additionally immobilized, however, the heating decreases by 30 %. Consequently, due to the binding of bigger MNP agglomerates at cellular level, heating efficiency inside tumors is assumed to decrease.

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Section: Introductioncontrasting

confidence: 49%

Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia

Engelmann

Buhl

Baumann

et al. 2017

Current Directions in Biomedical Engineering

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“…In addition, our nano-heaters (PEI-MNPs) effectively destroyed these 'micro-tumor-like' pellets, which are smaller than those previously reported by Wilhelm and co-workers (2x10 7 cells). 30,31 Baba et al 32 reported differences between superparamagnetic and ferromagnetic particles designed to treat MCF-7…”

Section: Figure 6 Tem and Fib-sem Micrographs Of Sh-sy5y Cells Subjementioning

confidence: 99%

Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating

et al. 2017

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“…While the heating of nanoparticles is undesirable for most applications, this property is of crucial importance for magnetic hyperthermia applications [14,16,17] (see also Refs. [18][19][20] and references therein). In a ferrofluid subjected to an external periodic magnetic field two heating mechanisms are usually considered [21,22], one of which is related to Brownian rotation of nanoparticles and the other to their Néel relaxation.…”

Section: Introductionmentioning

confidence: 99%

Energy dissipation in single-domain ferromagnetic nanoparticles: Dynamical approach

et al. 2015

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We study, both analytically and numerically, the phenomenon of energy dissipation in single-domain ferromagnetic nanoparticles driven by an alternating magnetic field. Our interest is focused on the power loss resulting from the Landau-Lifshitz-Gilbert equation, which describes the precessional motion of the nanoparticle magnetic moment. We determine the power loss as a function of the field amplitude and frequency and analyze its dependence on different regimes of forced precession induced by circularly and linearly polarized magnetic fields. The conditions to maximize the nanoparticle heating are also analyzed.

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Magnetic hyperthermia efficiency in the cellular environment for different nanoparticle designs

Cited by 361 publications

References 41 publications

Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia

Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia

Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating

Energy dissipation in single-domain ferromagnetic nanoparticles: Dynamical approach

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