Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating

Sanz, Beatriz; Calatayud, M. Pilar; Torres, Teobaldo E.; Fanarraga, Mónica L.; Ibarra, M. R.; Goya, Gerardo F.

doi:10.1016/j.biomaterials.2016.11.008

Cited by 106 publications

(72 citation statements)

References 36 publications

(46 reference statements)

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“…Our results did not show the hyperthermic effects described by other authors for similar particles and field conditions [26][27][28][29][30] , some of which even reported an increase in the effects mediated by MHT compared to external hyperthermia [73][74] . This suggests that the heating capacity of the MNPs used in this study was reduced when associated to cells compared to their performance in water.…”

Section: Influence Of Cell-induced Nanoparticle Aggregation On Mnp Macontrasting

confidence: 99%

Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

Mejías

Flores

Talelli

et al. 2018

ACS Appl. Mater. Interfaces

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Magnetic hyperthermia has a significant potential to be a new breakthrough for cancer treatment. The simple concept of nanoparticle-induced heating by the application of an alternating magnetic field has attracted much attention, as it allows the local heating of cancer cells, which are considered more susceptible to hyperthermia than healthy cells, while avoiding the side effects of traditional hyperthermia. Despite the potential of this therapeutic approach, the idea that local heating effects due to the application of alternating magnetic fields on magnetic nanoparticle-loaded cancer cells can be used as a treatment is controversial. Several studies indicate that the heating capacity of magnetic nanoparticles is largely reduced in the cellular environment due to increased viscosity, aggregation and dipolar interactions. However, an increasing number of studies, both in vitro and in vivo, show evidence of successful magnetic hyperthermia treatment on several different types of cancer cells. This apparent contradiction might be due to the use of different experimental conditions. Here we analyze the effects of several parameters on the cytotoxic efficiency of magnetic nanoparticles as heat inductors under an alternating magnetic field. Our results indicate that cell-nanoparticle interaction reduces the cytotoxic effects of magnetic hyperthermia, independently of nanoparticle coating and core size, the cell line used and the subcellular localization of nanoparticles. However, there seems to occur a synergistic effect between the application of an external source of heat and the presence of magnetic nanoparticles, leading to higher toxicities than those induced by heat alone, or the accumulation of nanoparticles within cells.

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Section: Influence Of Cell-induced Nanoparticle Aggregation On Mnp Macontrasting

confidence: 99%

Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

Mejías

Flores

Talelli

et al. 2018

ACS Appl. Mater. Interfaces

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“…Bañobre‐López et al and Rodrigues et al were pioneer in demonstrating the local temperature increase around magnetic heat mediators and their superior bactericide effect on food spoilage microorganisms in both planktonic and biofilm living states when subjected to magnetic fluid hyperthermia, compared to the situation in which the heat is traditionally and macroscopically applied. This superior effect of magnetic hyperthermia compared to other conventional methods of macroscopic heating has been extended later on to eukaryotic and tumor cells . The localized thermal effect of magnetic hyperthermia was also correlated with the gene expression of enhanced green fluorescent protein (EGFP) in human lung adenocarcinoma cells, expression that was found to be linked to the intracellular temperature increase due to the cell stress induced to the cell even when this temperature increase was not macroscopically observed.…”

Section: Representative Biomedical Applicationsmentioning

confidence: 88%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

494

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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“…As mentioned above, these NPs were designed to induce tumour cells to die by the mechanical rotation. Meanwhile, there were also plenty of NPs designed to kill tumour cells by the local temperature rise [10,11,28]. Thus, we further investigate the relationship between the internalization and hyperthermia performance, then try to figure out which mechanism acts as the main role of Zn 0. without NPs and human osteosarcoma MG-63 cells with NPs but without AMF were used as negative and positive control groups, respectively.…”

Section: Relationship Of Cell Uptake and Magnetic Hyperthermia Efficimentioning

confidence: 99%

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

Wang¹,

Liu²,

Liu³

et al. 2020

R. Soc. open sci.

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Zn 0.5 Fe 2.5 O 4 nanoparticles (NPs) of 22 nm are synthesized by a one-pot approach and coated with silica for magnetic hyperthermia agents. The NPs exhibit superparamagnetic characteristics, high-specific absorption rate (SAR) (1083 wg −1 , f = 430 kHz, H = 27 kAm −1 ), large saturation magnetization ( M s = 85 emu g −1 ), excellent colloidal stability and low cytotoxicity. The cell uptake properties have been investigated by Prussian blue staining, transmission electron microscopy and the inductively coupled plasma-mass spectrometer, which resulted in time-dependent and concentration-dependent internalization. The internalization appeared between 0.5 and 2 h, the NPs were mainly located in the lysosomes and kept in good dispersion after incubation with human osteosarcoma MG-63 cells. Then, the relationship between cell uptake and magnetic hyperthermia performance was studied. Our results show that the hyperthermia efficiency was related to the amount of internalized NPs in the tumour cells, which was dependent on the concentration and incubation time. Interestingly, the NPs could still induce tumour cells to apoptosis/necrosis when extracellular NPs were rinsed, but the cell kill efficiency was lower than that of any rinse group, which indicated that local temperature rise was the main factor that induced tumour cells to death. Our findings suggest that this high SAR and biocompatible silica-coated Zn 0.5 Fe 2. O 4 NPs could serve as new agents for magnetic hyperthermia.

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Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating

Cited by 106 publications

References 36 publications

Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

Advances in Magnetic Nanoparticles for Biomedical Applications

The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents

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Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating

Cited by 106 publications

References 36 publications

Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

Advances in Magnetic Nanoparticles for Biomedical Applications

The cell uptake properties and hyperthermia performance of Zn 0.5 Fe 2.5 O 4 /SiO 2 nanoparticles as magnetic hyperthermia agents

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The cell uptake properties and hyperthermia performance of Zn _0.5 Fe _2.5 O ₄ /SiO ₂ nanoparticles as magnetic hyperthermia agents