Biodegradation Mechanisms of Iron Oxide Monocrystalline Nanoflowers and Tunable Shield Effect of Gold Coating

Javed, Yasir; Lartigue, Lénaïc; Hugounenq, Pierre; Vuong, Quoc Lam; Gossuin, Yves; Bazzi, Rana; Wilhelm, Claire; Ricolleau, Christian; Gazeau, Florence; Alloyeau, Damien

doi:10.1002/smll.201400281

Cited by 44 publications

(68 citation statements)

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“…IONPs were previously shown to degrade in a minimal medium mimicking the acidic lysosome environment and consisting of sodium citrate (10 mM) at pH = 4.7542434445. Here we also observe the degradation of CoIONPs in this acidic citrate medium (Fig.…”

Section: Resultssupporting

confidence: 74%

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

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Kolosnjaj‐Tabi

Javed

et al. 2017

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Metallic nanoparticles have been increasingly suggested as prospective therapeutic nanoplatforms, yet their long-term fate and cellular processing in the body is poorly understood. Here we examined the role of an endogenous iron storage protein – namely the ferritin – in the remediation of biodegradable cobalt ferrite magnetic nanoparticles. Structural and elemental analysis of ferritins close to exogenous nanoparticles within spleens and livers of mice injected in vivo with cobalt ferrite nanoparticles, suggests the intracellular transfer of degradation-derived cobalt and iron, entrapped within endogenous protein cages. In addition, the capacity of ferritin cages to accommodate and store the degradation products of cobalt ferrite nanoparticles was investigated in vitro in the acidic environment mimicking the physiological conditions that are present within the lysosomes. The magnetic, colloidal and structural follow-up of nanoparticles and proteins in the lysosome-like medium confirmed the efficient remediation of nanoparticle-released cobalt and iron ions by ferritins in solution. Metal transfer into ferritins could represent a quintessential process in which biomolecules and homeostasis regulate the local degradation of nanoparticles and recycle their by-products.

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Section: Resultssupporting

confidence: 74%

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

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Kolosnjaj‐Tabi

Javed

et al. 2017

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“…The kinetics of degradation depended on NPs surface coating, size, shape, and architecture. [4c,e,18,23] Herein, we chose archetypical 7–8 nm superparamagnetic IONPs made by coprecipitation with different coating in order to evidence the role of ferritin in their degradation process ( Figure ). Their superparamagnetic properties, NMR relaxation behavior, colloidal stability, and morphology were first followed in an aqueous medium at pH 4.7 and 20 × 10 −3 m citrate in the absence of ferritin.…”

Section: Resultsmentioning

confidence: 99%

Ferritin Protein Regulates the Degradation of Iron Oxide Nanoparticles

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Carn

Kolosnjaj‐Tabi

et al. 2016

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Proteins implicated in iron homeostasis are assumed to be also involved in the cellular processing of iron oxide nanoparticles. In this work, the role of an endogenous iron storage protein-namely the ferritin-is examined in the remediation and biodegradation of magnetic iron oxide nanoparticles. Previous in vivo studies suggest the intracellular transfer of the iron ions released during the degradation of nanoparticles to endogenous protein cages within lysosomal compartments. Here, the capacity of ferritin cages to accommodate and store the degradation products of nanoparticles is investigated in vitro in the physiological acidic environment of the lysosomes. Moreover, it is questioned whether ferritin proteins can play an active role in the degradation of the nanoparticles. The magnetic, colloidal, and structural follow-up of iron oxide nanoparticles and proteins in lysosome-like medium confirms the efficient remediation of potentially harmful iron ions generated by nanoparticles within ferritins. The presence of ferritins, however, delays the degradation of particles due to a complex colloidal behavior of the mixture in acidic medium. This study exemplifies the important implications of intracellular proteins in processes of degradation and metabolization of iron oxide nanoparticles.

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“…Overall in situ observations of NHs degradation confirm the protective roles of polymer and of the gold/iron oxide interface on degradation, shielding the iron oxide from citrate iron chelators. 32,33 Properties of NHs during Transformation.…”

Section: Degradation Of Nhs In Acidic Mediummentioning

confidence: 99%

The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice

et al. 2015

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Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.

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Biodegradation Mechanisms of Iron Oxide Monocrystalline Nanoflowers and Tunable Shield Effect of Gold Coating

Cited by 44 publications

References 53 publications

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

Ferritin Protein Regulates the Degradation of Iron Oxide Nanoparticles

The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice

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