The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice

Kolosnjaj‐Tabi, Jelena; Javed, Yasir; Lartigue, Lénaïc; Volatron, Jeanne; Elgrabli, Dan; Marangon, Iris; Pugliese, Giammarino; Caron, B.; Figuerola, Albert; Luciani, Nathalie; Pellegrino, Teresa; Alloyeau, Damien; Gazeau, Florence

doi:10.1021/acsnano.5b00042

Cited by 194 publications

(194 citation statements)

References 62 publications

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“…The tendency of accumulation and hence slow clearance of SPIONs from the liver of mice after cell death is similar to the fate of free particles systemically injected in mice. 36 The spleen has very short relaxation time baseline values, and no further reduction was observed until the last imaging day in the case of free SPIONs (Fig. 5).…”

Section: Mri Complementary To Blimentioning

confidence: 90%

“…Recently, the long term in vivo fate of different hybrids of SPIONs with gold nanoparticles has been established after directly injecting the particles in the blood stream of mice which revealed a predominant accumulation of particles in liver and spleen for longer periods of time. 36 In similar studies, the accumulation and metabolism of particles in the liver and spleen and loss of magnetic characteristics as a function of their surface coating, inner core and formation of protein corona was evaluated. [37][38][39][40] The electron paramagnetic resonance (EPR) based measurements of iron oxide nanocubes showed their considerable elimination from liver on day 7 post administration, whereas half of the proportion of particles stored in the spleen was still detected on day 7 post injection.…”

Section: Mri Complementary To Blimentioning

confidence: 99%

“…Our studies demonstrate a similar accumulation and elimination pattern of particles injected via labelled cells to what has been reported for the particles directly injected in the blood stream. [36][37][38][39][40] …”

Section: Introductionmentioning

confidence: 99%

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In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

Ashraf

Taylor

Sharkey

et al. 2018

Preprint

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Nanoparticle contrast agents are useful tools to label stem cells and monitor the in vivo biodistribution of labeled cells in pre-clinical models of disease. In this context, understanding the in vivo fate of the particles after injection of labelled cells is important for their eventual clinical use as well as for the interpretation of imaging results. We examined how the formulation of superparamagnetic iron oxide nanoparticles (SPIONs) impacts the labelling efficiency, magnetic characteristics and fate of the particles by comparing individual SPIONs with polyelectrolyte multilayer capsules containing SPIONs. At low labelling concentration, encapsulated SPIONs served as an efficient labelling agent for stem cells. The bio-distribution after intra-cardiac injection of labelled cells was monitored longitudinally by MRI and as an endpoint by inductively coupled plasma-optical emission spectrometry. The results suggest that, after being released from labelled cells after cell death, both formulations of particles are initially stored in liver and spleen and are not completely cleared from these organs 2 weeks post-injection.

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Section: Mri Complementary To Blimentioning

confidence: 90%

Section: Mri Complementary To Blimentioning

confidence: 99%

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In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

Ashraf

Taylor

Sharkey

et al. 2018

Preprint

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“…It was revealed that the initial surface properties have impact on the degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. [376] Overall, although gold offers a lot of advantages for MNP, there are some difficulties that should overcome. The direct coating of iron oxide with gold is hard due the dissimilarity in the nature of the two crystalline surfaces making the coating to be weak which can be overcome by using TiO 2 as a bridging material.…”

Section: Gold Coatingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Au-NPs are known to primarily accumulate in the organs of the RES (e.g., liver) and show slow clearance over several months. 37,38 Therefore, this persistent retention could result in chronic toxicity within these tissues. In addition, degradation of Au-NPs could result in formation of smaller particles that are known to be toxic, as previously mentioned.…”

Section: Gold and Silver Npsmentioning

confidence: 99%

Facilitating Translational Nanomedicine via Predictive Safety Assessment

et al. 2017

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Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nanobased therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.During the past decades, engineered nanomaterials (ENMs) have been widely used in biomedical applications, such as nanomedicine, bioimaging, and tissue engineering, because of their unique biophysicochemical properties.1,2 With regard to nanomedicine applications, ENMs could be formulated as drug carriers that deliver the therapeutic reagents within the human body and increase their bioavailability and blood circulation half-life.2 Moreover, these nanocarriers could be functionalized to deliver the drug specifically to the desired target tissues (e.g., tumors) and release the payload sustainably over long periods, thereby eliminating the necessity of multiple drug administration and reducing its cytotoxic side effects toward healthy cells.2 In addition to their implementation in drug delivery, ENMs could be used for diagnostic and imaging purposes that would help to monitor the disease and administer the treatment more accurately. 2Past research in nanomedicine has led to the design of various nanomaterial-based therapeutic and diagnostic systems that are being investigated in experimental stages (e.g., in vitro and in vivo) and clinical trials or are commercially available to the corresponding patients (Table 1). Most commercialized nanomaterial-based therapeutic reagents use lipids, proteins, and polymers that could self-assemble and biodegrade with few side effects.3 Because of high biocompatibility of lipids, several commercial liposome-drug formulations have been developed, mostly relying on polyethylene glycol (PEG)-conjugated lipids, such as DOXIL, AmBisome, Epaxal, and Inflexal V, and are under clinical trials focusing on various types of disease treatments. 4,5 Polymer-based nanoparticles (NPs) also present low toxicity, but their surface functionalization may affect their safety. The most commonly used materials include PEG, ploy(lactic-co-glycolic) acid (PLGA...

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The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice

Cited by 194 publications

References 62 publications

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Facilitating Translational Nanomedicine via Predictive Safety Assessment

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