Repetitive hyperbaric oxygen therapy provides better effects on brain inflammation and oxidative damage in rats with focal cerebral ischemia

Lifan, Chen; Tian, Ye; Lin, Cheng‐Hsien; Huang, Lian-Yu; Niu, Ko‐Chi; Lin, Mao‐Tsun

doi:10.1016/j.jfma.2014.03.012

Cited by 34 publications

(32 citation statements)

References 39 publications

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“…The animals were placed in hyperbaric chambers as previously described [10]. Then, the pressure was increased to 0.25 MPa at a rate of 100 kPa per min, and each treatment lasted for 60 min.…”

Section: Hyperbaric Therapiesmentioning

confidence: 99%

“…Increasing evidence suggests that superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase activity are increased after repeated HBO treatments [9,10], although some reports show that HBO treatment may cause excessive generation of ROS, which induces neuronal cell damage [2]. On the other hand, HBO therapy attenuates hypoxia in affected tissues, which is helpful for the protection of neuronal function.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Pan

Chen

Huang

et al. 2015

Neuroscience Letters

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Section: Hyperbaric Therapiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Pan

Chen

Huang

et al. 2015

Neuroscience Letters

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“…The use of silymarin may therefore be considered a novel therapeutic strategy for protection against lung I/R injury. Animal and clinical trials have confirmed that the inflammatory response is focal to continuing tissue damage following cerebral ischemia, and this is observed to a greater degree following lung I/R injury (14,15). Reduction in the inflammatory response is therefore an important strategy to attenuate lung I/R injury.…”

mentioning

confidence: 99%

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Jin

Zhao

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Silymarin is a traditional therapeutic used to protect the liver, acting to oppose lipid peroxidation, to enhance liver regeneration and functioning as an antioxidant. However, the effects of silymarin on pulmonary vascular dysfunction have not been investigated. In the present study, the modulatory effects of silymarin on pulmonary vascular dysfunction and the underlying mechanisms behind this were investigated in a lung ischemia-reperfusion (I/R) injury rat model. Male Sprague Dawley rats were randomly divided into 3 groups, including: i) A control group (n=10); ii) an I/R group (n=10); and iii) a silymarin-treated group (n=10). All experimental rats received 250 mg/kg/day of silymarin for 8 days. Silymarin was demonstrated to markedly improve lung I/R-induced pulmonary vascular dysfunction and lung moisture. Following silymarin treatment, inflammation and oxidative stress in the lung I/R-injury rats were demonstrably suppressed. Treatment with silymarin also inhibited the activation of caspase-3 and -9, and hypoxia inducible factor-1α (HIF-1α) and inducible nitric oxide synthase (iNOS) protein expression in the lung I/R-injury rats. Silymarin was concluded to impact upon pulmonary vascular dysfunction through the HIF-1α-iNOS pathway in the lung I/R injury rat model.

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“…A large number of experimental studies have shown that changing the oxygen pressure in the body can greatly affect macrophage function . Hyperbaric oxygen therapy (HBOT), which is widely used, is the most representative example.…”

Section: Exogenous Inducers Of Macrophage Heterogeneitymentioning

confidence: 99%

Heterogeneous macrophages: Supersensors of exogenous inducing factors

et al. 2019

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This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractAs heterogeneous immune cells, macrophages mount effective responses to various internal and external changes during disease progression. Macrophage polarization, rather than macrophage heterogenization, is often used to describe the functional differences between macrophages. While macrophage polarization partially contrib-

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Repetitive hyperbaric oxygen therapy provides better effects on brain inflammation and oxidative damage in rats with focal cerebral ischemia

Abstract: The results provide the apparently contradictory finding that heightened oxygen tension reduced oxidative stress (and inflammation), which was reflected by increased antioxidant and decreased oxidant contents under focal cerebral ischemia.

Cited by 34 publications

References 39 publications

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Heterogeneous macrophages: Supersensors of exogenous inducing factors

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