Minor Salivary Gland Neoplasms

Dalğıç, Abdullah; Karakoç, Ömer; Aydın, Ümit; Hıdır, Yusuf; Gamsızkan, Mehmet; Karahatay, Serdar; Gerek, Mustafa

doi:10.1097/scs.0000000000000723

Cited by 21 publications

(16 citation statements)

References 17 publications

(23 reference statements)

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“…A similar study by Abdullah et al showed that the painless mass in the palate was predominant presentation in 73% of patients. 13 These findings were in accordance to our present study. ACC usually shows no specific signs and symptoms.…”

Section: Discussionsupporting

confidence: 94%

Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

Doddrangaiah¹,

Karunakaran²,

Mallali³

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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Section: Discussionsupporting

confidence: 94%

Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

Doddrangaiah¹,

Karunakaran²,

Mallali³

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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“…Tumors located in the parotid gland usually require superficial or radical parotidectomy for infiltrative cases, compromising the maintenance of the facial nerve [1]. For minor SGC, commonly located in the palate, maxillectomy is typically required [58]. The amount of sequels and high morbidity, which is associated with low survival rates over long-term periods, underscore the need to identify therapies that improve survival and quality of life.…”

Section: Discussionmentioning

confidence: 99%

Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis

et al. 2016

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Patients with mucoepidermoid carcinoma (MEC) experience low survival rates and high morbidity following treatment, yet the intrinsic resistance of MEC cells to ionizing radiation (IR) and the mechanisms underlying acquired resistance remain unexplored. Herein, we demonstrated that low doses of IR intrinsically activated NFκB in resistant MEC cell lines. Moreover, resistance was significantly enhanced in IR-sensitive cell lines when NFκB pathway was stimulated. Pharmacological inhibition of the IKK-β/IκBα/NFκB axis, using a single dose of FDA-approved Emetine, led to a striking sensitization of MEC cells to IR and a reduction in cancer stem cells. We achieved a major step towards better understanding the basic mechanisms involved in IR-adaptive resistance in MEC cell lines and how to efficiently overcome this critical problem.

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“…The management of ACC in minor salivary glands remains controversial. Several studies recommend prophylactic neck dissection if the nodes are clinically negative. For minor salivary glands, a study argued in their exploration of 12 patients that elective neck dissections should not be performed if cN0 necks are present unless they have high‐grade muco‐epidermoid carcinoma.…”

Section: Early Stage Disease (T1/2) ‐ Risk Of N+ Disease In the Parotid?mentioning

confidence: 99%

Current management of the neck in salivary gland carcinomas

Green

Rahimi

Brennan

2016

J Oral Pathology Medicine

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Salivary gland cancers include a diverse group of tumours with many histological subtypes which occur in both major and minor salivary glands. As a result of this heterogeneity and different sites of presentation, there have been no randomised controlled trials to evaluate the indications and efficacy of neck treatments by either surgery or radiotherapy for occult or apparent neck node metastases. Neck dissection is an important treatment strategy for neck metastases arising from major and minor salivary gland malignancy as well as being useful for disease staging. However, there is considerable controversy in how to manage the neck in these patients. In this review, we discuss the management of neck metastases relating to malignant salivary gland tumours.

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Minor Salivary Gland Neoplasms

Abstract: Minor salivary gland tumors are relatively uncommon neoplasms of the head and neck region. There is limited literature on MSGTs. This study provides a versatile approach for MSGTs from demographic data and clinical presentations to treatment modalities and treatment outcomes.

Cited by 21 publications

References 17 publications

Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis

Current management of the neck in salivary gland carcinomas

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