Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study

Chong, Mary Foong-Foong; Wong, Jocelyn X.Y.; Colega, Marjorelee; Chen, Ling‐Wei; Dam, Rob M. van; Tan, Chuen Seng; Lim, Ai Lin; Cai, Shirong; Broekman, Birit F.P.; Lee, Yung Seng; Saw, Seang Mei; Kwek, Kenneth; Godfrey, Keith M.; Yap, Fabian; Gluckman, Peter D.; Meaney, Michael J.; Chen, Helen

doi:10.1016/j.jpsychires.2014.04.006

Cited by 112 publications

(42 citation statements)

References 33 publications

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“…The findings in this study are not consistent with the statistically nonsignificant findings in previous studies in which investigators looked at the general relationship between serum Vitamin B12 and depression in pregnant women (Chong et al, 2014;Lukose et al, 2014). In both of these studies, investigators used established screening tools (but not the PHQ-9) to assess depression.…”

Section: Discussioncontrasting

confidence: 99%

“…In two multivariate studies (Chong et al, 2014;Lukose et al, 2014), no significant relationship was found between serum Vitamin B12 level and depression in pregnant women. These studies used different depression-screening measures and included women from Singapore who were in their second trimester and women from South India in their first trimester.…”

Section: Introductionmentioning

confidence: 90%

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Risk of depression in pregnant women with low‐normal serum Vitamin B12

Peppard

Gallo

et al. 2019

Research in Nursing & Health

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High prevalence rates of both Vitamin B12 insufficiency and depressive symptoms exist in pregnant women. Although the association between depressive symptoms and certain nutrient deficiencies like iron, folate, or Vitamin B12 has been established, the specific relationship between low‐normal serum Vitamin B12 levels and depressive symptoms in pregnant women in the United States has not been studied closely. Using 2005–2006 National Health and Nutrition Examination Survey data, a secondary analysis was conducted to examine the association between low‐normal serum Vitamin B12 level and depression, as measured by a score of 10 or higher on the Patient Health Questionnaire‐9, in pregnant women (N = 174). In bivariate regression models, Vitamin B12 level, experiencing poverty, and pre‐pregnancy body mass index (BMI) were significant predictors of depression. In multivariate logistic regression models, pregnant women with low‐normal serum Vitamin B12 levels (OR = 3.82, 95% CI [1.10–13.31], p < 0.04) were 3.82 times more likely to experience depression, controlling for sociodemographic characteristics, pre‐pregnancy BMI, and the biomarkers hemoglobin and folate. Identifying and treating pregnant women with low‐normal Vitamin B12 levels may enhance prenatal depression management.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Risk of depression in pregnant women with low‐normal serum Vitamin B12

Peppard

Gallo

et al. 2019

Research in Nursing & Health

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“…The power calculation was carried out using online software (Open Source Epidemiologic Statistics for Public Health, Version 3.01, Emory University, and Rollins School of Public Health). We calculated the sample size using mean and standard deviation of plasma vitamin B12 levels in postpartum depression reported earlier by Chong et al (19) . The estimated sample size was 217 subjects in each group (total 434 subjects), at 5% level of signi cance and 80% power.…”

Section: Methodsmentioning

confidence: 99%

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Dhiman

Pillai

Wilson

et al. 2020

Preprint

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BackgroundVitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule SAM. Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression. MethodsWomen attending postpartum clinic at 6 weeks post-delivery were screened for the presence of depressive symptoms using Edinburg postpartum depression scale (EPDS). Based on a cut-off of 10, two groups were taken- women with probable depression with EPDS score>10 (n=217) and women without probable depression with EPDS score<10(n=217). Plasma total vitamin B12, holotranscobalamin, homocysteine, MMA, 5-methyl THF, SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12(cB12) score was calculated and analysis of resulting data was done using SPSS ver20.0. ResultsTotal vitamin B12 was significantly lower (p=0.001) and MMA (p=0.002) and 5-methyl THF(p<0.001) levels were higher in women with probable depression than women without probable depression. Combined B12 index was also lower in women with probable PPD (p=0.001). Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189-0.822) and cB12 (OR=0.293; 95% CI:0182-0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63-2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59-6.83) were significantly associated with the risk of PPD.ConclusionLow vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.

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“…42 GUSTO study by Chong et al has determined that plasma vitamin B12 concentrations have no correlation to perinatal depression and although low plasma folic acid status during pregnancy is linked to antenatal depression, it has no correlation to postnatal depression. 43 …”

Section: Folic Acid -Vitamin B₁₂ -Vitamin B6mentioning

confidence: 99%

Correlation between postpartum depression and omega-3, micronutrients

Mermer

Şanlıer

2017

Int J Reprod Contracept Obstet Gynecol

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In recent years, attention has been called to the link between nutrition and mental health. Postpartum depression is an important depressive disorder which often arises 6 to 12 weeks after giving birth and can happen at any time within one year. Postpartum depression prevalence is around 20% worldwide. Genetic predisposition and environmental factors, as well as certain social, psychological and biological factors constitute risk factors for postpartum depression. While malnutrition is among the biological factors, there is a correlation between nutrients such as folic acid, vitamin B₁₂, vitamin D, iron, selenium, zinc, and n-3 fatty acids and psychological state. The nutrients that claim most attention relating to postpartum depression are n-3 essential fatty acids. Insufficient intake of n-3, folic acid, vitamins B and iron is observed in pregnant women. Failing to meet the needs of the mother due to malnutrition during pregnancy can increase the risk of depleting the body’s nutrient reserves and developing postpartum. This risk factor needs to be kept in check by determining and keeping track of the nutrient needs of the mother during the perinatal period.

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Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study

Cited by 112 publications

References 33 publications

Risk of depression in pregnant women with low‐normal serum Vitamin B12

Risk of depression in pregnant women with low‐normal serum Vitamin B12

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Correlation between postpartum depression and omega-3, micronutrients

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