Risk of depression in pregnant women with low‐normal serum Vitamin B12

Peppard, Lora; Oh, Kyeung Mi; Gallo, Sina; Milligan, Renée A.

doi:10.1002/nur.21951

Cited by 20 publications

(8 citation statements)

References 39 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also observed that compared to controls more women with PPD had low normal vitamin B12 (49.8% versus 27.2% in controls; P = 0.001). Similar findings in ante-natal depression is reported recently in 174 pregnant women using secondary data analysis of National Health and Nutrition Examination Survey data, CDC, in USA [ 23 ]. They observed higher frequency of antenatal depression in women with low normal vitamin B12 ( n = 9; 15.2%) compared with those with sufficient vitamin B12 ( n = 6; 5.2%).…”

Section: Discussionsupporting

confidence: 89%

Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women

Dhiman

Pillai

Wilson

et al. 2021

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background Vitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule S-Adenosyl Methionine (SAM). Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression. Methods We included women who visited the hospital at 6-weeks postpartum for a regular checkup. Inclusion criteria were age (18–50 years), and willingness to donate venous sample for analysis. Exclusion criteria included previous history of mood disorders or antidepressant medication use, and any systemic illness like hypothyroidism, epilepsy, diabetes, and hypertension. Based on EPDS score of 10 as a cutoff, 217 women with probable postpartum depression (PPD) and equal number of age and BMI matched controls were included. Plasma total vitamin B12, holotranscobalamin (holotc), homocysteine (hcy), methyl malonic acid (MMA), 5-methyl tetrahydrofolate (THF), SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12 (cB12) score was calculated from study parameters. Multivariate analysis was performed to assess the risk of probable postpartum depression. Results Total vitamin B12 and combined B12 score were found to be significantly lower (p = 0.001) and MMA (p = 0.002) and 5-methyl THF (p < 0.001) levels were higher in women with probable depression than women without probable PPD. Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Multivariate analysis demonstrated that decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189–0.822) and cB12 (OR = 0.293; 95% CI: 0182–0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63–2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59–6.83) were significantly associated with the risk of probable PPD. Conclusion Low vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.

show abstract

Section: Discussionsupporting

confidence: 89%

Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women

Dhiman

Pillai

Wilson

et al. 2021

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…We also observed that compared to controls more women with PPD had low normal vitamin B12 (49.8% versus 27.2% in controls; P = 0.001). Similar ndings in ante-natal depression is reported recently in 174 pregnant women using secondary data analysis of National Health and Nutrition Examination Survey data, CDC, in USA (23) . They observed higher frequency of antenatal depression in women with low normal vitamin B12 (n = 9; 15.2%) compared with those with su cient vitamin B12 (n = 6; 5.2%).…”

Section: Discussionsupporting

confidence: 88%

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Dhiman

Pillai

Wilson

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundVitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule SAM. Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression. MethodsWomen attending postpartum clinic at 6 weeks post-delivery were screened for the presence of depressive symptoms using Edinburg postpartum depression scale (EPDS). Based on a cut-off of 10, two groups were taken- women with probable depression with EPDS score>10 (n=217) and women without probable depression with EPDS score<10(n=217). Plasma total vitamin B12, holotranscobalamin, homocysteine, MMA, 5-methyl THF, SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12(cB12) score was calculated and analysis of resulting data was done using SPSS ver20.0. ResultsTotal vitamin B12 was significantly lower (p=0.001) and MMA (p=0.002) and 5-methyl THF(p<0.001) levels were higher in women with probable depression than women without probable depression. Combined B12 index was also lower in women with probable PPD (p=0.001). Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189-0.822) and cB12 (OR=0.293; 95% CI:0182-0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63-2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59-6.83) were significantly associated with the risk of PPD.ConclusionLow vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.

show abstract

“…Indeed, dietary aspects and diet components (ex. vitamin D, folate, selenium intake, iron, vitamin B12, vitamin K, fiber intake, zinc) as well as diet-related inflammatory potential have been linked to depression outcomes [ 161 , 208 , 236 , 312 , 396 , 402 , 403 , 404 , 405 , 406 , 407 , 408 , 409 , 410 , 411 , 412 , 413 , 414 , 415 , 416 , 417 , 418 , 419 , 420 , 421 , 422 , 423 , 424 , 425 , 426 , 427 , 428 ]. A poor diet has been linked to depression through mechanisms such as inflammation [ 428 ].…”

Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

View full text Add to dashboard Cite

Depression is one of the leading causes of disability, and, if left unmanaged, it can increase the risk for suicide. The evidence base on the determinants of depression is fragmented, which makes the interpretation of the results across studies difficult. The objective of this study is to conduct a thorough synthesis of the literature assessing the biological, psychological, and social determinants of depression in order to piece together the puzzle of the key factors that are related to this condition. Titles and abstracts published between 2017 and 2020 were identified in PubMed, as well as Medline, Scopus, and PsycInfo. Key words relating to biological, social, and psychological determinants as well as depression were applied to the databases, and the screening and data charting of the documents took place. We included 470 documents in this literature review. The findings showed that there are a plethora of risk and protective factors (relating to biological, psychological, and social determinants) that are related to depression; these determinants are interlinked and influence depression outcomes through a web of causation. In this paper, we describe and present the vast, fragmented, and complex literature related to this topic. This review may be used to guide practice, public health efforts, policy, and research related to mental health and, specifically, depression.

show abstract

Risk of depression in pregnant women with low‐normal serum Vitamin B12

Cited by 20 publications

References 39 publications

Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women

Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women

Cross-sectional Association Between Vitamin B12 Status and Probable Postpartum Depression in Indian Women

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Contact Info

Product

Resources

About