Phenolic constituents from the roots of Phyllodium pulchellum

Abstract

Three new phenolic constituents 1-3 were obtained from the 95% ethanol extract of the roots of Phyllodium pulchellum (Leguminosae). Their structures were elucidated on the basis of spectroscopic analyses, such as NMR, UV, IR, HR-ESI-MS, and CD. Furthermore, in an in vitro bioassay, all compounds were tested for inhibitory effects against the proliferation of acetaldehyde-stimulated HSC-T6 cells, and compound 3 exhibited potent inhibitory activity with the IC50 value of 7.6 μM.

Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products

“…3 Other phenolcontaining natural products arise from the direct oxidative coupling of tethered free phenols to afford a phenol-dienone motif (Figure 1B,C). 4,5 Since the discovery that direct phenol oxidation plays a critical role in the biosynthesis of such compounds, 6−8 analogous reagent-based approaches have been of considerable interest for their potential application in the synthesis of plant metabolites.…”

“…Bisphenols constitute an important class of molecules with utility as both complex molecule precursors and biologically active natural products. , Such biologically active compounds often incorporate the bisphenol biaryl motif as part of a polycyclic system (Figure A) . Other phenol-containing natural products arise from the direct oxidative coupling of tethered free phenols to afford a phenol-dienone motif (Figure B,C). , Since the discovery that direct phenol oxidation plays a critical role in the biosynthesis of such compounds, − analogous reagent-based approaches have been of considerable interest for their potential application in the synthesis of plant metabolites.…”

Lignans and Flavonoids from Cajanus cajan (L.) Millsp. and Their α‐Glucosidase Inhibitory Activities

“…The known compounds ( Figure 1) were identified as isoswertisin ( 4 ), [14] taxifolin ( 5 ), [15] caudatan B ( 6 ), [16] (2 R ,4 R )‐2‐(5‐hydroxy‐2‐methylphenyl)‐8‐(3‐methylbut‐2‐en‐1‐yl)‐4‐(l‐oxidaneyl)chromane‐3,7‐diol ( 7 ), [17] 8‐prenykaempferol ( 8 ), [18] 2‐(2,4‐dihydroxyphenyl)‐3,5‐dihydroxy‐7‐methoxy‐8‐(3‐methylbut‐2‐en‐1‐yl)chroman‐4‐one ( 9 ), [19] 8‐prenylquercretin ( 10 ), [20] citrusinol ( 11 ), [21] pulcheloid B ( 12 ), [22] yokovanol ( 13 ), [23] apigenin ( 14 ), [24] 8‐dimethylallyltaxifolin ( 15 ), [25] genistein ( 16 ), [26] naringenin ( 17 ), [27] shuterin ( 18 ), [28] kaempferol ( 19 ), [29] aromadendrin ( 20 ), [30] luteolin ( 21 ), [31] quercetin ( 22 ) [29] by comparing their spectrascopic data with those from previous reports.…”

Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain

“…Previous research had shown that chemical constituents of P. pulchellum included alkaloids, alcohols, and phenols. In total alkaloids part, indolealkylamine (IAA) and β -carboline type alkaloids were its main constituents [ 3 – 5 ]. To the best of our knowledge, these alkaloids are regarded as the promising plant-derived compounds to treat CNS illnesses, due to their unique complex nitrogen-containing structures to interact with diverse neuronal and molecular targets [ 6 ].…”