Quality of Life for Patients Treated for Penile Cancer

Kieffer, Jacobien M.; Djajadiningrat, Rosa S.; Muilekom, Erik A.M. van; Graafland, Niels M.; Horenblas, Simon; Aaronson, Neil K.

doi:10.1016/j.juro.2014.04.014

Cited by 122 publications

(104 citation statements)

References 26 publications

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“…We did not observe any association between BMI and AJCC stage at presentation when correcting for covariates as circumcision, smoking and age. This finding is in contrast with Barnes et al [4] who did find an association between higher BMI and higher AJCC stage at diagnosis with correction for the same covariates in a comparable population regarding age and race [9]. A possible explanation for this contradiction may be the difference in BMI between the two study populations.…”

Section: Discussioncontrasting

confidence: 89%

Penile Cancer Stage, Survival and Body Mass Index

Djajadiningrat¹,

Werkhoven²,

Horenblas³

2015

Urol Int

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Objective: The aim of this study was to determine whether a higher body mass index (BMI) in penile cancer patients is associated with more advanced penile cancer stage at the time of treatment and cancer survival. Methods: We evaluated 433 penile cancer patients treated between 2006 and 2012 at our institute and recorded American Joint Committee on Cancer (AJCC) stage, BMI, circumcision, smoking and age. A proportional odds model was used to assess a possible association between BMI and AJCC stage at diagnosis and controlled for circumcision, smoking and age. Five-year disease-specific survival was calculated using the Kaplan-Meier method, with the log-rank test assessing equality of distributions. Results: 433 patients with a mean BMI of 26.8 kg/m² were analyzed. No statistically significant association between BMI and AJCC stage was found (odds ratio 1.01 per 1 kg/m² increase in BMI, 95% confidence interval 0.97-1.05, p = 0.63). Differences in disease-specific survival were not observed based on the different BMI classes. Conclusions: No association between BMI of penile cancer patients and their disease stage at the time of treatment was observed. Thus, BMI at penile cancer treatment does not affect prognosis.

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Section: Discussioncontrasting

confidence: 89%

Penile Cancer Stage, Survival and Body Mass Index

Djajadiningrat¹,

Werkhoven²,

Horenblas³

2015

Urol Int

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“…GR and TGN [2, 3, 6-8, 13, 15-18]. Moreover, organ-preserving techniques reduce the negative impact on function, cosmetic appearance and quality of life compared to amputation [19,20]. Although organ-preserving techniques convey a higher risk of local recurrence, most recurrences are surgically salvageable and overall mortality is comparable to that following primary amputation [13,[21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

“…The preservation of sexual function following penile-sparing surgery has been inconsistently reported in the literature, and only one study so far has included validated tools or questionnaires for the evaluation of sexual function [20]. In order to evaluate organ-sparing reconstructive surgery in a more rigorous and scientific fashion a prospective study of patient-related outcome, recurrences and overall mortality is planned by our group.…”

mentioning

confidence: 99%

Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres

Håkansson

Kirrander

Uvelius

et al. 2014

Scandinavian Journal of Urology

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Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres.Håkansson, Ulf; Kirrander, Peter; Uvelius, Bengt; Baseckas, Gediminas; Torbrand, Christian Link to publication Citation for published version (APA): Håkansson, U., Kirrander, P., Uvelius, B., Baseckas, G., & Torbrand, C. (2015). Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres. Scandinavian Journal of Urology, 49(2), 149-154. DOI: 10.3109/21681805.2014.955822 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Conclusions: GR and TGN seem to be oncologically safe procedures for treating carefully selected patients with penile cancer, and the functional and cosmetic results are promising.Based on our findings, we recommend that penile amputation should only be carried out in patients not suitable for organ-sparing reconstructive surgery.

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“…We excluded those positive to the sentinel node biopsy (n = 8) and those who received a modified monolateral inguinal lymph node dissection to avoid bias in terms of either oncological and functional outcomes. 4 Adhering to EAU guidelines, 12 we planned the surgical treatments. Patients with preoperative satisfying erectile function and concerned about the preservation of their sexual potency were scheduled for WLE (Group A) or glansectomy with urethral glanduloplasty (Group B), according to tumour characteristics.…”

Section: Methodsmentioning

confidence: 99%

“…3 Excellent oncological results can be achieved with radical approaches, in spite of a devastating impact on patient quality of life and sexual function. [4][5][6][7] Historically, the primary tumour has been surgically treated with demolitive technique, such as partial or total amputation. A standard 2-cm free margin was believed necessary to achieve excellent oncologic results.…”

Section: Introductionmentioning

confidence: 99%

Sexual function after surgical treatment for penile cancer: Which organ-sparing approach gives the best results?

Sedigh

Falcone

Ceruti

et al. 2015

CUAJ

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E423Cite as: Can Urol Assoc J 2015;9(7-8):E423-7. http://dx.doi.org/10.5489/cuaj.2801 Published online July 17, 2015. AbstractIntroduction: We compared the postoperative sexual function of patients who underwent wide local excision (WLE) and glansectomy with urethral glanduloplasty for penile cancer. Methods: We retrospectively reviewed clinical data of 41 patients affected by superficial, localized penile cancer (≤cT2a) between 2006 and 2013. Patients with severe erectile dysfunction and not interested in resuming an active sexual life were selected for penile partial amputation. Patients with preoperative satisfying erectile function and concerned about the preservation of their sexual potency were scheduled for WLE (Group A) or glansectomy with urethral glanduloplasty (Group B). Sexual function was assessed with the International Index of Erectile Function (IIEF) questionnaire and the Sex Encounter Profile (SEP). At 1 year, patients were asked to complete the questionnaires again and were questioned about their genital sensibility and ejaculatory reflex persistence. Postoperative complications were reported according to the Clavien-Dindo classification. Statistical analysis was performed by two-tailed test: Student t-test and chi-square. Results: Among the 41 patients enrolled, 12 underwent WLE (29.2%), 23 glansectomy with urethral glanduloplasty (56%) and 6 with penile partial amputation (14.6%). A decrease in postoperative IIEF was recorded in both groups, but was statistically significant only in Group B (p = 0.003). As for the SEP, while no significant changes were recorded postoperatively in Group A, a marked reduction was reported for Group B, with a statistically significant decrease in the possibility of achieving penetrative intercourse (p = 0.006) and in the perceived satisfaction during sexual activity (p = 0.004). Conclusions: WLE lead to better sexual outcomes and less postoperative complications as compared to glansectomy with urethral glanduloplasty.

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Quality of Life for Patients Treated for Penile Cancer

Cited by 122 publications

References 26 publications

Penile Cancer Stage, Survival and Body Mass Index

Penile Cancer Stage, Survival and Body Mass Index

Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres

Sexual function after surgical treatment for penile cancer: Which organ-sparing approach gives the best results?

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